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Table 2 Sparse k-means clustering results a

From: Identification of Chiari Type I Malformation subtypes using whole genome expression profiles and cranial base morphometrics

Description Individual clustering
  Dura Blood Cranial
Optimal k classes b 2 2 2
  Class 1 (N) 24 25 21
  Class 2 (N) 20 19 19
Optimal tuning parameter 68.27 81.71 3.66
  N non-zero weighted features (%) c    
   Dura 11804 (100%) NA NA
   Blood NA 11804 (100%) NA
   Cranial NA NA 18 (75%)
  Maximum weighted feature (weight)    
   Dura MECOM (0.21) NA NA
   Blood NA RPS7 (0.17) NA
   Cranial NA NA BASTOREF (0.72)
Gap statistic d 1.152 ± 0.013 1.834 ± 0.014 0.487 ± 0.136
  95% Confidence interval 1.126-1.178 1.807-1.860 0.222-0.753
  P-value <1.0E-10 <1.0E-10 1.62E-04
  1. Abbreviations: N: number, MECOM: MDS1 and EVI1 complex locus, RPS7: ribosomal protein S7, BASTOREF: basion to reference line, NA: not applicable.
  2. aClustering results presented using individual datasets (Dura: dura gene expression data, Blood: blood gene expression data, Cranial: PF trait data).
  3. b44 individuals were included for the dura and blood gene expression individual clustering analyses; 40 individuals were included for all other analyses.
  4. c11804 gene expression probes and/or 24 posterior fossa traits (features) were used as input.
  5. dThe gap statistic ± standard error is presented. Gap statistics with an approximate p-value less than 0.05 are shown in bold.