Figure 7From: Kinome and mRNA expression profiling of high-grade osteosarcoma cell lines implies Akt signaling as possible target for therapy Unsupervised clustering of peptides which can be phosphorylated by Akt. Unsupervised clustering depicting differential phosphorylation of peptides of the PI3K/Akt pathway by cell lysates treated with different concentrations of MK—2206 and for different time intervals, as compared with untreated cells. Blue: logFC < 0, orange: logFC > 0. Different treatment options are shown in different shades of gray (from light to dark gray: 1 μM 5, 30, 180, 960, and 10 μM 180 minutes of treatment with MK-2206. Light-green: 143B, dark green: U-2 OS.Back to article page