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Table 9 Signaling pathways predicted to be regulated by altered miRNAs in ARDS

From: MicroRNA and mRNA expression profiling in rat acute respiratory distress syndrome

Pathway Target number Score
Axon guidance 57 31.92
ErbB signaling pathway 37 19.04
MAPK signaling pathway 80 17.12
Focal adhesion 64 16.73
Regulation of actin cytoskeleton 67 15.37
Colorectal cancer 34 14.74
Chronic myeloid leukemia 31 14.18
Wnt signaling pathway 48 12.55
Glycan structures - biosynthesis 1 40 12.39
Glioma 26 12.37
Pancreatic cancer 28 11.05
Renal cell carcinoma 26 9.49
TGF-beta signaling pathway 31 9.33
Small cell lung cancer 30 8.79
Long-term potentiation 24 8.68
Oxidative phosphorylation 6 8.34
Prostate cancer 30 8.22
Circadian rhythm 8 8.17
Arachidonic acid metabolism 1 7.92
mTOR signaling pathway 20 7.78
Antigen processing and presentation 3 7.3
Adherens junction 25 7.01
Acute myeloid leukemia 21 6.96
T cell receptor signaling pathway 29 6.00
Melanoma 23 5.72
Tryptophan metabolism 1 5.68
Endometrial cancer 18 5.31
Glycosphingolipid biosynthesis - neo-lactoseries 8 5.01
Type II diabetes mellitus 16 4.82
Complement and coagulation cascades 4 4.78
GnRH signaling pathway 28 4.76
Insulin signaling pathway 37 4.44
Melanogenesis 28 4.40
Non-small cell lung cancer 17 4.25
  1. Mapping all the changed miRNAs in ARDS to signaling pathways was performed by DIANA-mirPath software (http://diana.cslab.ece.ntua.gr/pathways). pā€‰<ā€‰0.01 was the statistical cutoff for DIANA-miRpath analysis. Target number: The number of miRNA target genes in a given pathway. Score: Enrichment statistical score, the negative natural logarithm of the P-value (-ln P).