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Table 4 Gene expression versus COMT methylation in human cell lines

From: Comprehensive interrogation of CpG island methylation in the gene encoding COMT, a key estrogen and catecholamine regulator

CpG units

Spearman’s rho

95% C.I.

p value

001_1

-.252

(-.923, .493)

.483

001_5

-.220

(-.886, .415)

.541

001_30

-.171

(-.889, .712)

.636

001_32

.020

(-.837, .808)

.956

001_33

-.049

(-.879, .698)

.894

001_avg

-.479

(-.950, .324)

.162

005_4

-.377

(-.808, .401)

.283

005_7

-.455

(-.920, .358)

.187

005_8

-.198

(-.863, .519)

.584

005_9

-.127

(-.801, .680)

.726

005_10

-.206

(-.808, .615)

.567

005_11

-.105

(-.801, .699)

.773

005_12

-.334

(-.849, .472)

.345

005_17

-.079

(-.892, .690)

.828

005_18

-.421

(-.919, .377)

.226

005_avg

-.333

(-.796, .405)

.347

006_3

-.683

(-.820, -.525)

.029*

006_5

-.806

(-.968, -.245)

.005**

006_9

-.782

(-.988, -.305)

.008**

006_12

-.733

(-.987, -.119)

.016*

006_13

-.860

(-.990, -.472)

.001**

006_avg

-.766

(-.963, -.082)

.010*

  1. Spearman correlation coefficients were calculated using a bootstrapping procedure based on log relative gene expression between ABI TaqMan probes for COMT and an 18S rRNA endogenous control with percent methylation values for CpG units in the top 40th percentile for differential methylation within the cell line samples. Methylation of COMT within amplicon 006 was significantly inversely correlated with COMT expression, with coefficients ranging from -0.683 to -0.860 (p = 0.029–0.001). Results are based on n = 10 tumors for which there were both complete methylation and gene expression data. * p< .05, ** p< .01, *** p< .001, uncorrected for FWE, FDR corrected (p < .05).