Table 4 The final mortality-predicting signature assessed using the Cox multivariate regression model

BMI

0.84 (0.77-0.91)

0.03

-4.22

<0.001

Frailty index (ref. = non-frail)

Pre-frail

9.53 (2.70-33.6)

6.12

3.51

<0.001

Frail

17.7 (4.61-67.9)

12.14

4.19

<0.001

TMEM70

0.39 (0.18-0.84)

0.15

-2.40

0.017

GADD45B

2.60 (1.02-6.62)

1.24

2.00

0.045

NME4

1.77 (1.11-2.80)

0.41

2.42

0.015

MBP

0.58 (0.36-0.93)

0.14

-2.27

0.023

CHEK2

0.26 (0.12-0.55)

0.10

-3.50

<0.001

VKORC1

0.33 (0.18-0.59)

0.10

-3.68

<0.001

LRCH3

0.47 (0.25-0.87)

0.15

-2.40

0.016

LTA

2.09 (1.37-3.19)

0.45

3.43

0.001

SH2D1B

0.52 (0.36-0.76)

0.10

-3.44

0.001