Association of miRNA levels with clinical chart parameters. Pearson correlations between different numerically continuous measurements of lung function or physiology and differentially expressed miRNAs were calculated for all STAMPEDE subjects. For simplicity, the negative log10 of calculated Pearson correlation values are displayed. Only relationships deemed to be potentially significant with p-value < 0.03 were depicted. a, BAL; b, Serum; c, Urine. DLCO, diffusing capacity for carbon monoxide; DLCO/VA, diffusing capacity for carbon monoxide adjusted for volume; ERS, European Respiratory Society; FEF25-75, mid-expiratory flow; FEV1, forced expiratory volume at one second; FVC, forced vital capacity; BD, bronchodilator; TLC, total lung capacity; RV, residual volume; IOS, impulse oscillometry; R5, total respiratory resistance; R20, proximal resistance; X5, distal capacitive reactance; Fres, resonant frequency; AX, reactance area; MCT, methacholine challenge testing; PFT, pulmonary function testing; HGB, hemoglobin; HCT, hematocrit; CD4/CD8, CD4 to CD8 lymphocyte ratio; WBC, white blood cell.