Figure 3

Genotype-dependent candidate CpGs that mediate genetic risk for EOC. (Left) Plot depicting the DNAm status of cg10061138, associated with gene STAB1, between (A) EOC cases and controls and by genotype at SNP rs11884397 (B). Red lines denote the median methylation levels. (C) Percentage of EOC cases by the number of minor alleles for SNP rs11884397. (D) Coefficient (β) reflects the log-odds of EOC for a one-unit increase in the number of minor alleles for SNP rs11884397 with and without adjustment for the methylation levels of cg10061138. Bars represent the 95% CI for the estimate of the log-odds (i.e., β). (E-H) Density plots of DNAm by genotype (AA = green, Aa = red, and aa = blue) for four EOC–associated CpGs; solid lines indicate the methylation distribution for EOC cases and dotted lines indicate the methylation distribution for controls.