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Table 2 CpG sites that were identified as potential mediators of genetic risk for EOC (CIT p < 0.05)

From: Integrative genomic analysis identifies epigenetic marks that mediate genetic risk for epithelial ovarian cancer

   CpGs associated with EOC   SNPs associated with CpGs
CpG Meth diff P-value (M vs Y) Gene Chr Pos SNP Chr Pos P-value (G vs M) P-value (G vs Y) P-value (CIT)
cg03718677 -0.08 4.60E-03 TMOD4 1 149414890 rs1250220 2 216320050 2.30E-07 0.023 0.023
cg03718677 -0.08 4.60E-03 TMOD4 1 149414890 rs1250252 2 216313591 1.70E-07 0.029 0.029
cg09822001 0.11 5.50E-04 APOA1BP 1 154827958 rs2919303 8 62214493 1.50E-07 0.027 0.027
cg10636246 -0.11 2.70E-04 AIM2 1 157313597 rs11120596 1 215850817 7.60E-07 0.002 0.002
cg10636246 -0.11 2.70E-04 AIM2 1 157313597 rs460380 21 46028864 5.30E-07 0.01 0.01
cg13721560 0.07 7.90E-03 LRPPRC 2 44076072 rs2289840 3 124181739 9.40E-08 0.041 0.041
cg10061138 -0.09 8.30E-04 STAB1 3 52504125 rs11884397 2 23885388 3.10E-07 0.002 0.002
cg25086702 0.1 1.70E-03 HMGB2 4 174492134 rs11210834 1 43787437 7.10E-08 0.048 0.048
cg24136586 0.1 5.50E-03 ATG10 5 81304122 rs3800524 6 168302015 1.80E-06 0.034 0.034
cg01495509 0.08 5.30E-03 KCNMB1 5 169748956 rs4457945 15 54608127 2.20E-08 0.019 0.019
cg25553916 0.06 6.90E-04 FLJ22318 5 177491361 rs2254066 2 29889019 2.60E-07 0.003 0.003
cg25553916 0.06 6.90E-04 FLJ22318 5 177491361 rs2631958 2 29958841 7.10E-07 0.009 0.009
cg25553916 0.06 6.90E-04 FLJ22318 5 177491361 rs6754181 2 29966380 3.10E-07 0.003 0.003
cg19436567 0.12 1.50E-04 ARID1B 6 157141067 rs12362925 11 16875419 7.80E-08 0.029 0.029
cg08142684 0.13 2.70E-04 TCP1 6 160129858 rs9792311 8 123940585 7.40E-07 0.023 0.023
cg05109049 0.09 5.30E-03 EVI2B 17 26665459 rs2294405 6 99292136 1.60E-06 0.013 0.013
cg00021527 0.09 5.20E-03 TAF15 17 31160293 rs10488500 7 76841259 2.50E-07 0.046 0.046
  1. M: Methylation, G: Genotype, Y: EOC status.
  2. Methdiff: Difference in the methylation M-value between EOC cases minus controls, adjusted for the estimated distribution of cell types, age, smoking status, alcohol consumption, study enrollment year, location of residence, parity and age at first birth, and the first principal component representing within-European population sub-structure.
  3. Gene: Denotes the nearest gene for the given CpG site.