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Table 2 CpG sites that were identified as potential mediators of genetic risk for EOC (CIT p < 0.05)

From: Integrative genomic analysis identifies epigenetic marks that mediate genetic risk for epithelial ovarian cancer

 

 CpGs associated with EOC

 

SNPs associated with CpGs

CpG

Meth diff

P-value (M vs Y)

Gene

Chr

Pos

SNP

Chr

Pos

P-value (G vs M)

P-value (G vs Y)

P-value (CIT)

cg03718677

-0.08

4.60E-03

TMOD4

1

149414890

rs1250220

2

216320050

2.30E-07

0.023

0.023

cg03718677

-0.08

4.60E-03

TMOD4

1

149414890

rs1250252

2

216313591

1.70E-07

0.029

0.029

cg09822001

0.11

5.50E-04

APOA1BP

1

154827958

rs2919303

8

62214493

1.50E-07

0.027

0.027

cg10636246

-0.11

2.70E-04

AIM2

1

157313597

rs11120596

1

215850817

7.60E-07

0.002

0.002

cg10636246

-0.11

2.70E-04

AIM2

1

157313597

rs460380

21

46028864

5.30E-07

0.01

0.01

cg13721560

0.07

7.90E-03

LRPPRC

2

44076072

rs2289840

3

124181739

9.40E-08

0.041

0.041

cg10061138

-0.09

8.30E-04

STAB1

3

52504125

rs11884397

2

23885388

3.10E-07

0.002

0.002

cg25086702

0.1

1.70E-03

HMGB2

4

174492134

rs11210834

1

43787437

7.10E-08

0.048

0.048

cg24136586

0.1

5.50E-03

ATG10

5

81304122

rs3800524

6

168302015

1.80E-06

0.034

0.034

cg01495509

0.08

5.30E-03

KCNMB1

5

169748956

rs4457945

15

54608127

2.20E-08

0.019

0.019

cg25553916

0.06

6.90E-04

FLJ22318

5

177491361

rs2254066

2

29889019

2.60E-07

0.003

0.003

cg25553916

0.06

6.90E-04

FLJ22318

5

177491361

rs2631958

2

29958841

7.10E-07

0.009

0.009

cg25553916

0.06

6.90E-04

FLJ22318

5

177491361

rs6754181

2

29966380

3.10E-07

0.003

0.003

cg19436567

0.12

1.50E-04

ARID1B

6

157141067

rs12362925

11

16875419

7.80E-08

0.029

0.029

cg08142684

0.13

2.70E-04

TCP1

6

160129858

rs9792311

8

123940585

7.40E-07

0.023

0.023

cg05109049

0.09

5.30E-03

EVI2B

17

26665459

rs2294405

6

99292136

1.60E-06

0.013

0.013

cg00021527

0.09

5.20E-03

TAF15

17

31160293

rs10488500

7

76841259

2.50E-07

0.046

0.046

  1. M: Methylation, G: Genotype, Y: EOC status.
  2. Methdiff: Difference in the methylation M-value between EOC cases minus controls, adjusted for the estimated distribution of cell types, age, smoking status, alcohol consumption, study enrollment year, location of residence, parity and age at first birth, and the first principal component representing within-European population sub-structure.
  3. Gene: Denotes the nearest gene for the given CpG site.
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BMC Medical Genomics

ISSN: 1755-8794

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