Figure 3

WITHIN-STUDY concordance of PTBP1-KD associated mechanisms found by N-of-1- pathways compared to those found by GSEA and DEG Enrichment, applied to breast and ovarian cancer gene expression microarray profile (Datasets II-III). To evaluate the GO-BP and KEGG associated terms of deregulated mechanisms yielded by the N-of-1-pathways method in both breast and ovarian cancer internal studies, we compared these mechanisms to those found by DEG Enrichment when GSEA is chosen as the 'Proxy' Gold Standard (Proxy GS, Methods). We then generated precision-recall curves based on the exact GO overlap (Without GO-ITS, panels A, D), related GO terms by Information Theory Similarity overlap (With GO-ITS, panels B, E; GO-ITS ≥ 0.7; Methods), and the exact KEGG overlap (panels C, F).