Figure 4

CROSS-STUDIES concordance of PTBP1-KD associated mechanisms found by N-of-1- pathways and conventional methods in breast and ovarian cancer cell lines using neuronal cell line mechanisms as Gold Standard. We compared mechanisms unveiled by N-of-1-pathways and DEG Enrichment in neuronal cell lines to those associated in breast and ovarian cancer cell lines and found by all three methods. We set RNA-Seq neuronal cell related results as a 'Proxy' Gold Standard (Proxy GS; Methods) and generated precision-recall curves using GO-BP semantic similarity overlap (GO-ITS ≥ 0.7; Methods).