Identification of novel therapeutics for complex diseases from genome-wide association data

BMC Medical Genomics

Table 2 Predicted known therapeutics

PH	Target	*Drug name	Status	Action	*Database
T1D	PPARG	Rosiglitazone	Approved	Agonist	TTD
	DGKA	Vitamin E	Approved	Unknown	DrugBank
T2D	CTSD	Insulin Regular	Approved	Unknown	DrugBank
	PPARA	Aleglitazar	Phase III	Agonist	TTD
	NR3C1	ISIS-GCCR	Preclinical	Antisense	TTD
	TCF7L2	Repaglinide	Unknown	Unknown	PharmGKB
	PPARD	Bezafibrate	Approved	Agonist	DrugBank
	RB1	Insulin, porcine	Approved	Unknown	DrugBank
	HSD11B1	INCB13739	Phase IIa	Inhibitor	TTD
RA	TNF	Infliximab	Approved	Inhibitor	DrugBank
	ITGA4	CDP323	Phase II	Antagonist	TTD
	JAK2	INCB18424	Phase III	Inhibitor	TTD
	IL15	AMG-714	Discontinued in phase I	Inhibitor	TTD
	CCL2	MCP-1	Preclinical	Inhibitor	TTD
	PRKCA	Vitamin E	Approved	Unknown	DrugBank
HT	DRD1	Fenoldopam	Approved	Agonist	TTD
	AGTR1	Valsartan	Approved	Antagonist	TTD
	CNR1	AZD1175	Discontinued in phase I	Antagonist	TTD
	AGT	Benazepril	Unknown	Unknown	PharmGKB
	GUCY1A2	Isosorbide Mononitrate	Approved	Inducer	DrugBank
BD	SLC6A2	Imipramine	Approved	Inhibitor	DrugBank
	AGTR1	Valsartan	Approved	Antagonist	DrugBank
CAD	MYC	AVI4126	Phase I/II	Antisense	TTD
	PLG	Urokinase	Approved	Activator	DrugBank
	NOS3	ACCLAIM	Phase III	Stimulator	TTD

Abbreviations - PH - Phenotypes; T2D - Type 2 Diabetes; BD - Bipolar Disorder; HT - Hypertension; T1D - Type 1 Diabetes; CAD - Coronary Artery Disease; RA - Rheumatoid Arthritis; TTD - Therapeutic Target Database; PharmGKB - Pharmacogenomics Knowledgebase.
Therapeutic targets with predicted known therapeutics for phenotypes of interest.
(^* Drugs mentioned in the table are only examples as one target may have multiple drugs);
(^* Drug databases in the table are only examples as one drug-target association may be present in more than one database).

ISSN: 1755-8794