Identification of novel therapeutics for complex diseases from genome-wide association data

BMC Medical Genomics

Table 3 Novel therapeutics suitable for repositioning for the seven diseases

PH	Target	*Drug name	Status	Current Indication	Action	*Database
T1D	RARA	Alitretinoin	Approved	Kaposi's sarcoma	Agonist	TTD
	GSK3B	Lithium	Unknown	Bipolar disorder	Unknown	PharmGKB
T2D	CHRM1	Pirenzepine	Approved	Peptic ulcer disease	Antagonist	TTD
	LPL	Gemfibrozil	Approved	Hyperlipidemia	Activator	TTD
CAD	FLT1	Sorafenib	Launched	Advanced renal cell carcinoma	Inhibitor	TTD
	KDR	Sunitinib	Launched	Advanced renal cell carcinoma	Inhibitor	TTD
BD	ESR1	Trilostane	Approved	Cushing's syndrome	^aModulator	DrugBank
	ABCC1	Methotrexate	Unknown	Psoriasis	Unknown	PharmGKB
HT	TACR1	GSK1144814	Phase I	Schizophrenia	Antagonist	TTD
	NRP1	Palifermin	Approved	Oral mucositis	Unknown	DrugBank
CD	CRHR1	CRF-1 antagonist	Phase II completed	Irritable bowel syndrome	Antagonist	TTD
	INSR	Insulin Detemir	Approved	Type I and II Diabetes	Agonist	DrugBank
RA	HLA - DRB 1	Glatiramer Acetate	Approved	Multiple sclerosis	Binder	TTD
	ACE	Ramipril	Approved	Hypertension	Inhibitor	DrugBank

Abbreviations - PH - Phenotypes; T2D - Type 2 Diabetes; T1D - Type 1 Diabetes; CAD - Coronary Artery Disease; BD - Bipolar Disorder; HT - Hypertension; CD - Crohn's Disease; RA - Rheumatoid Arthritis; TTD - Therapeutic Target Database; PharmGKB - Pharmacogenomics Knowledgebase.
Examples of novel therapeutics suitable for repositioning towards cure of seven diseases. (* Drugs mentioned in the table are only examples as one target may have multiple drugs); (* Drug databases in the table are only examples as one drug-target association may be present in more than one database); (^a Allosteric Modulator).

ISSN: 1755-8794