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Table 1 Performance of EvoD, PolyPhen-2 and SIFT when analyzing PharmGKB variants.

From: Evolutionary Diagnosis of non-synonymous variants involved in differential drug response

  Diagnosis Rate  
Method TNR FPR FNR TPR Balanced Accuracy
EvoD 49% 51% 61% 39% 44%
PolyPhen-2 60% 40% 55% 45% 52%
SIFT 46% 54% 47% 53% 50%
  1. Note – TPR: True Positive Rate (sensitivity), FPR: False Positive Rate, TNR: True Negative Rate (Specificity), FNR: False Negative Rate