Novel therapeutics for coronary artery disease from genome-wide association study data

BMC Medical Genomics

Table 2 Replicated therapeutics for CAD

Target	*Drug name	Status	Action	*Database
PLG	Anistreplase	Approved	Activator	TTD
ALOX5AP	DG031	Suspended in Phase III	Inhibitor	TTD
PLAT	Urokinase	Approved	Activator	DrugBank
AGTR1	Losartan	Approved	Antagonist	DrugBank
NOS3	ACCLAIM	Phase III	Unknown	DrugBank
PLAUR	Urokinase	Approved	Activator	DrugBank
NID1	Urokinase	Approved	Unknown	DrugBank
MYC	AVI4126	Phase I/II	Antisense	TTD

Eight therapeutic targets with examples of replicated known therapeutics for CAD in this study.
* Drugs shown are examples. More than one therapeutic drug may be associated with each replicated target; * Drug databases shown are examples. One drug-target association may be described in more than one drug database. Abbreviations - PH - Phenotype; CAD - Coronary Artery Disease; TTD - Therapeutic Target Database.

ISSN: 1755-8794