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Table 1 Distribution of variants by SIFT score in the AML patients and the healthy controls

From: Interpretation of personal genome sequencing data in terms of disease ranks based on mutual information

SIFT AML patients Healthy controls in the 1000 Genomes Project
Score Impact No. of variants % No. of variants % No. of variants % No. of variants %
0 Damaging 131 26.52 421 18.21 339 17.51 333 19.44
0.001-0.050 Damaging 73 14.78 375 16.22 290 14.99 260 15.18
0.051-0.100 Potentially damaging 25 5.06 173 7.48 146 7.55 129 7.53
0.101-0.200 Borderline 28 5.67 295 12.76 242 12.51 190 11.09
0.201-0.500 Tolerant 63 12.75 441 19.07 358 18.50 326 19.03
0.501-0.999 Tolerant 53 10.73 298 12.89 245 12.66 212 12.38
1.00 Tolerant 121 24.49 309 13.37 315 16.28 263 15.35
Total   494 100.00 2312 100.00 1935 100.00 1713 100.00