WGCNA analysis of the human HD/R6/2 consensus dataset indicates commonly dysregulated pathways. (A) Visualization of modules that are highly correlated with Huntington’s disease (HD) state and genotype of R6/2 mice. Size is the number of genes for each module. P
adj gives the Benjamini Hochberg corrected significance value of correlation with human HD/R6/2 for each module. (B) Correlations of eigengene based connectivity (kME) versus the gene significance for human HD and R6/2. The two modules with the highest absolute correlation are shown for each dataset. cor = correlation. (C - E) Visualization of hub genes in human HD/R6/2 consensus network modules. The 50 most connected genes (nodes) and the 500 strongest gene-gene interactions (edges) in each module are shown. The width and the color saturation of the lines (edges) correspond to the weight of the interactions. (F and G) Hub gene comparison of human HD/R6/2 consensus modules versus modules of the HD caudate nucleus (CN) dataset. Venn diagrams show the overlap of hub genes in the respective consensus modules with HD caudate nucleus modules. Only consensus modules with an overlap of 5 or more genes to CN modules are shown.