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Table 1 Codon and gene coverage of the 1052-amplicon panel

From: Evaluation of an integrated clinical workflow for targeted next-generation sequencing of low-quality tumor DNA using a 51-gene enrichment panel

Gene Transcript Codon
ABL1 ENST00000318560 85-505
AKT1 ENST00000349310 1-96, 146-189, 277-391, 455-481
AKT2 ENST00000392038 192-320
BRAF ENST00000288602 393-664
CDH1* ENST00000261769 1-883
CDK4 ENST00000257904 1-73, 228-273
CDKN2A* ENST00000446177 1-153
CEBPA* ENST00000498907 1-359
CREBBP ENST00000262367 1-29, 853-929, 1328-1465, 1725-1761, 2196-2299
CTNNB1* ENST00000396185 1-782
EGFR* ENST00000275493 1-1211
ERBB2 ENST00000269571 147-215
FES ENST00000328850 72-223
FGFR1* ENST00000447712 1-823
FGFR3 ENST00000340107 206-760
FLT3 ENST00000241453 437-685, 807-885
FOXL2 ENST00000330315 91-158
GATA1 ENST00000376670 1-200
GNA11 ENST00000078429 202-245
GNAQ ENST00000286548 159-245
HIF1A* ENST00000337138 1-827
HRAS* ENST00000397594 1-150
IDH1 ENST00000345146 41-174, 284-331
IDH2 ENST00000330062 125-178
IKBKB ENST00000520810 311-375, 580-662
JAK2 ENST00000381652 443-711, 858-903
KIT* ENST00000288135 1-977
KRAS* ENST00000256078 1-150
MEN1* ENST00000377326 1-611
MET ENST00000318493 981-1330
MPL ENST00000372470 180-230, 440-522
NF2* ENST00000361166 1-579
NOTCH1* ENST00000277541 21-2556
NPM1 ENST00000393820 47-118
NRAS ENST00000369535 1-97
PAX5 ENST00000358127 71-137, 304-367
PDGFRA ENST00000257290 552-960, 1041-1090
PIK3CA ENST00000263967 21-106, 301-353, 418-582, 672-729, 889-1069
PIK3R1* ENST00000521657 1-725
PTCH1* ENST00000331920 1-1448
PTEN* ENST00000371953 1-404
PTPN11 ENST00000351677 46-111, 483-533
RB1* ENST00000267163 1-491, 500-929
RET ENST00000355710 627-694, 870-934
SMAD4* ENST00000342988 1-302, 319-553
SMARCB1* ENST00000263121 1-386
SMO* ENST00000249373 1-788
SRC* ENST00000445403 1-537
STK11* ENST00000326873 1-434
TP53* ENST00000269305 1-394
VHL ENST00000256474 1-52, 104-214
  1. The table shows the list of genes, transcripts and codons targeted by the 1052-amplicon panel. In sum, the panel covers over 10,000 mutations annotated in v64 of the COSMIC database, including single nucleotide variants (SNVs) and small indels up to 2 bp. The transcript models used for codon identification are based on Ensembl Genomes release 17 (GRCh37). *All codons are covered in the genes marked with an asterisk.