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Table 8 Comparison with previously published data

From: Integrated differential transcriptome maps of Acute Megakaryoblastic Leukemia (AMKL) in children with or without Down Syndrome (DS)

Gene Location References 'A' /' B' 'A' /'D' 'B' /'D' 'A '/' E' 'B' /' E' 'A' /' C' 'C' / 'D' 'C '/' E'
MK markers          
BST2 19p13.11 [23] 0.53 5.36 10.07 7.21 13.56 7.97 0.67 0.91
GATA1 Xp11.23 [13],[22],[48] 3.39 1.45 0.43 1.97 0.58 1.19 1.22 1.66
GP1BA 17p13.2 [43] 0.46 0.07 0.14 0.25 0.53 0.81 0.08 0.30
HBG1 11p15.5 [22] 2.36 1.40 0.59 1.07 0.45 0.78 1.79 1.37
HBG2 11p15.5 [22] 2.47 1.31 0.53 1.06 0.43 0.71 1.84 1.48
ITGA2B 17q21.32 [23] 0.82 0.63 0.77 1.52 1.84 1.05 0.60 1.44
ITGB3 17q21.32 [23] 0.75 0.08 0.10 0.10 0.13 0.65 0.12 0.15
PF4 4q12-q21 [25] 0.90 0.06 0.06 0.11 0.12 0.44 0.13 0.25
PPBP 4q12-q13 [25] 1.45 0.10 0.07 0.13 0.09 0.28 0.34 0.44
TAL1 1p32 [23] 0.85 0.19 0.22 0.16 0.19 1.05 0.18 0.16
Chr21 genes          
ADAMTS1 21q21.2 [49] 6.19 7.02 1.14 7.14 1.15 1.82 3.85 3.91
BACH1 21q22.11 [22] 1.86 1.44 0.77 1.04 0.56 1.55 0.93 0.67
DYRK1A 21q22.13 [50] 1.61 0.87 0.54 0.63 0.39 1.14 0.77 0.55
ERG 21q22.3 [18],[22] 0.68 3.47 5.12 3.10 4.57 1.42 2.44 2.18
ETS2 21q22.2 [18],[22] 0.93 1.11 1.20 1.39 1.49 0.73 1.52 1.90
GABPA 21q21.3 [18],[22] 1.39 2.45 1.76 1.52 1.10 1.55 1.58 0.98
RUNX1 21q22.3 [18],[22] 0.71 1.08 1.51 0.84 1.18 1.06 1.01 0.80
SOD1 21q22.11 [51] 1.88 1.52 0.81 2.78 1.48 1.52 1.00 1.84
SON 21q22.11 [22] 1.28 1.39 1.08 1.03 0.80 1.44 0.96 0.71
Other genes
APOC1 19q13.2 [20],[22],[23] 4.37 10.04 2.30 16.26 3.72 1.79 5.63 9.11
APOC2 19q13.2 [22] 4.36 37.04 8.49 43.48 9.96 1.43 25.88 30.37
APOE 19q13.2 [22],[23] 2.18 3.57 1.64 3.24 1.48 1.56 2.30 2.08
CDA 1p36.2-p35 [23] 0.39 0.40 1.03 0.88 2.24 0.88 0.46 1.00
DICER1 14q32.13 [18] 0.80 0.41 0.51 0.27 0.34 0.99 0.41 0.27
FCER1A 1q23 [22],[23] 6.32 4.28 0.68 8.86 1.40 1.32 3.25 6.72
GYPA 4q31.21 [23] 3.40 1.56 0.46 0.89 0.26 1.19 1.31 0.75
GYPB 4q31.21 [23] 2.81 1.28 0.46 0.89 0.31 1.27 1.01 0.70
GYPE 4q31.1 [23] 2.07 1.63 0.79 1.71 0.82 1.72 0.95 0.99
HDC 15q21-q22 [22],[23] 17.10 9.95 0.58 32.72 1.91 1.22 8.16 26.83
IGF1R 15q26.3 [17] 0.76 1.18 1.55 0.94 1.24 1.21 0.98 0.78
ITGAL 16p11.2 [52] 0.79 0.21 0.26 0.09 0.11 1.02 0.20 0.09
KIT 4q11-q12 [22] 1.66 3.34 2.01 3.08 1.85 1.22 2.74 2.53
MPL 1p34 [53] 1.11 0.31 0.28 0.22 0.20 1.23 0.25 0.18
MTOR 1p36.22 [17] 0.87 1.57 1.82 1.94 2.24 0.89 1.76 2.17
MYCN 2p24.3 [21] 0.35 1.00 2.87 0.77 2.19 0.34 2.99 2.28
PRAME 22q11.22 [21] 1.60 11.59 7.24 15.61 9.76 4.18 2.77 3.73
SMOX 20p13 [23] 1.37 0.76 0.55 1.02 0.75 0.79 0.96 1.30
ST18 8q11.23 [18] 0.90 0.74 0.82 0.74 0.82 0.78 0.96 0.95
  1. Expression values of genes known for their role in MK differentiation and DS or non-DS AMKL development in each of the eight comparisons: DS AMKL (pool 'A') vs. non-DS AMKL (pool 'B'); DS AMKL (pool 'A') vs. normal MK (pool 'D'); non-DS AMKL (pool 'B') vs. normal MK (pool 'D'); DS AMKL (pool 'A') vs. normal CB MK (pool 'E') cells; non-DS AMKL (pool 'B') vs. normal CB MK (pool 'E'); DS AMKL (pool 'A') vs. TMD (pool 'C'); TMD (pool 'C') vs. normal MK (pool 'D'); TMD (pool 'C') vs. normal CB MK (pool 'E'). Data extracted from the full tables showing expression values and their ratio for about 17-26,000 loci for each comparison. In bold: expression ratio values are consistent with data available in the literature (see references indicated). The other values are reported for completeness. Descriptions of the gene symbols are given in Additional file 2.
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