Gene
|
Location
|
References
|
'A' /' B'
|
'A' /'D'
|
'B' /'D'
|
'A '/' E'
|
'B' /' E'
|
'A' /' C'
|
'C' / 'D'
|
'C '/' E'
|
---|
MK markers
| | | | | | | | | |
BST2
|
19p13.11
|
[23]
|
0.53
|
5.36
|
10.07
|
7.21
|
13.56
|
7.97
|
0.67
|
0.91
|
GATA1
|
Xp11.23
|
[13],[22],[48]
|
3.39
|
1.45
|
0.43
|
1.97
|
0.58
|
1.19
|
1.22
|
1.66
|
GP1BA
|
17p13.2
|
[43]
|
0.46
|
0.07
|
0.14
|
0.25
|
0.53
|
0.81
|
0.08
|
0.30
|
HBG1
|
11p15.5
|
[22]
|
2.36
|
1.40
|
0.59
|
1.07
|
0.45
|
0.78
|
1.79
|
1.37
|
HBG2
|
11p15.5
|
[22]
|
2.47
|
1.31
|
0.53
|
1.06
|
0.43
|
0.71
|
1.84
|
1.48
|
ITGA2B
|
17q21.32
|
[23]
|
0.82
|
0.63
|
0.77
|
1.52
|
1.84
|
1.05
|
0.60
|
1.44
|
ITGB3
|
17q21.32
|
[23]
|
0.75
|
0.08
|
0.10
|
0.10
|
0.13
|
0.65
|
0.12
|
0.15
|
PF4
|
4q12-q21
|
[25]
|
0.90
|
0.06
|
0.06
|
0.11
|
0.12
|
0.44
|
0.13
|
0.25
|
PPBP
|
4q12-q13
|
[25]
|
1.45
|
0.10
|
0.07
|
0.13
|
0.09
|
0.28
|
0.34
|
0.44
|
TAL1
|
1p32
|
[23]
|
0.85
|
0.19
|
0.22
|
0.16
|
0.19
|
1.05
|
0.18
|
0.16
|
Chr21 genes
| | | | | | | | | |
ADAMTS1
|
21q21.2
|
[49]
|
6.19
|
7.02
|
1.14
|
7.14
|
1.15
|
1.82
|
3.85
|
3.91
|
BACH1
|
21q22.11
|
[22]
|
1.86
|
1.44
|
0.77
|
1.04
|
0.56
|
1.55
|
0.93
|
0.67
|
DYRK1A
|
21q22.13
|
[50]
|
1.61
|
0.87
|
0.54
|
0.63
|
0.39
|
1.14
|
0.77
|
0.55
|
ERG
|
21q22.3
|
[18],[22]
|
0.68
|
3.47
|
5.12
|
3.10
|
4.57
|
1.42
|
2.44
|
2.18
|
ETS2
|
21q22.2
|
[18],[22]
|
0.93
|
1.11
|
1.20
|
1.39
|
1.49
|
0.73
|
1.52
|
1.90
|
GABPA
|
21q21.3
|
[18],[22]
|
1.39
|
2.45
|
1.76
|
1.52
|
1.10
|
1.55
|
1.58
|
0.98
|
RUNX1
|
21q22.3
|
[18],[22]
|
0.71
|
1.08
|
1.51
|
0.84
|
1.18
|
1.06
|
1.01
|
0.80
|
SOD1
|
21q22.11
|
[51]
|
1.88
|
1.52
|
0.81
|
2.78
|
1.48
|
1.52
|
1.00
|
1.84
|
SON
|
21q22.11
|
[22]
|
1.28
|
1.39
|
1.08
|
1.03
|
0.80
|
1.44
|
0.96
|
0.71
|
Other genes
|
APOC1
|
19q13.2
|
[20],[22],[23]
|
4.37
|
10.04
|
2.30
|
16.26
|
3.72
|
1.79
|
5.63
|
9.11
|
APOC2
|
19q13.2
|
[22]
|
4.36
|
37.04
|
8.49
|
43.48
|
9.96
|
1.43
|
25.88
|
30.37
|
APOE
|
19q13.2
|
[22],[23]
|
2.18
|
3.57
|
1.64
|
3.24
|
1.48
|
1.56
|
2.30
|
2.08
|
CDA
|
1p36.2-p35
|
[23]
|
0.39
|
0.40
|
1.03
|
0.88
|
2.24
|
0.88
|
0.46
|
1.00
|
DICER1
|
14q32.13
|
[18]
|
0.80
|
0.41
|
0.51
|
0.27
|
0.34
|
0.99
|
0.41
|
0.27
|
FCER1A
|
1q23
|
[22],[23]
|
6.32
|
4.28
|
0.68
|
8.86
|
1.40
|
1.32
|
3.25
|
6.72
|
GYPA
|
4q31.21
|
[23]
|
3.40
|
1.56
|
0.46
|
0.89
|
0.26
|
1.19
|
1.31
|
0.75
|
GYPB
|
4q31.21
|
[23]
|
2.81
|
1.28
|
0.46
|
0.89
|
0.31
|
1.27
|
1.01
|
0.70
|
GYPE
|
4q31.1
|
[23]
|
2.07
|
1.63
|
0.79
|
1.71
|
0.82
|
1.72
|
0.95
|
0.99
|
HDC
|
15q21-q22
|
[22],[23]
|
17.10
|
9.95
|
0.58
|
32.72
|
1.91
|
1.22
|
8.16
|
26.83
|
IGF1R
|
15q26.3
|
[17]
|
0.76
|
1.18
|
1.55
|
0.94
|
1.24
|
1.21
|
0.98
|
0.78
|
ITGAL
|
16p11.2
|
[52]
|
0.79
|
0.21
|
0.26
|
0.09
|
0.11
|
1.02
|
0.20
|
0.09
|
KIT
|
4q11-q12
|
[22]
|
1.66
|
3.34
|
2.01
|
3.08
|
1.85
|
1.22
|
2.74
|
2.53
|
MPL
|
1p34
|
[53]
|
1.11
|
0.31
|
0.28
|
0.22
|
0.20
|
1.23
|
0.25
|
0.18
|
MTOR
|
1p36.22
|
[17]
|
0.87
|
1.57
|
1.82
|
1.94
|
2.24
|
0.89
|
1.76
|
2.17
|
MYCN
|
2p24.3
|
[21]
|
0.35
|
1.00
|
2.87
|
0.77
|
2.19
|
0.34
|
2.99
|
2.28
|
PRAME
|
22q11.22
|
[21]
|
1.60
|
11.59
|
7.24
|
15.61
|
9.76
|
4.18
|
2.77
|
3.73
|
SMOX
|
20p13
|
[23]
|
1.37
|
0.76
|
0.55
|
1.02
|
0.75
|
0.79
|
0.96
|
1.30
|
ST18
|
8q11.23
|
[18]
|
0.90
|
0.74
|
0.82
|
0.74
|
0.82
|
0.78
|
0.96
|
0.95
|
- Expression values of genes known for their role in MK differentiation and DS or non-DS AMKL development in each of the eight comparisons: DS AMKL (pool 'A') vs. non-DS AMKL (pool 'B'); DS AMKL (pool 'A') vs. normal MK (pool 'D'); non-DS AMKL (pool 'B') vs. normal MK (pool 'D'); DS AMKL (pool 'A') vs. normal CB MK (pool 'E') cells; non-DS AMKL (pool 'B') vs. normal CB MK (pool 'E'); DS AMKL (pool 'A') vs. TMD (pool 'C'); TMD (pool 'C') vs. normal MK (pool 'D'); TMD (pool 'C') vs. normal CB MK (pool 'E'). Data extracted from the full tables showing expression values and their ratio for about 17-26,000 loci for each comparison. In bold: expression ratio values are consistent with data available in the literature (see references indicated). The other values are reported for completeness. Descriptions of the gene symbols are given in Additional file 2.