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Table 8 Comparison with previously published data

From: Integrated differential transcriptome maps of Acute Megakaryoblastic Leukemia (AMKL) in children with or without Down Syndrome (DS)

Gene

Location

References

'A' /' B'

'A' /'D'

'B' /'D'

'A '/' E'

'B' /' E'

'A' /' C'

'C' / 'D'

'C '/' E'

MK markers

         

BST2

19p13.11

[23]

0.53

5.36

10.07

7.21

13.56

7.97

0.67

0.91

GATA1

Xp11.23

[13],[22],[48]

3.39

1.45

0.43

1.97

0.58

1.19

1.22

1.66

GP1BA

17p13.2

[43]

0.46

0.07

0.14

0.25

0.53

0.81

0.08

0.30

HBG1

11p15.5

[22]

2.36

1.40

0.59

1.07

0.45

0.78

1.79

1.37

HBG2

11p15.5

[22]

2.47

1.31

0.53

1.06

0.43

0.71

1.84

1.48

ITGA2B

17q21.32

[23]

0.82

0.63

0.77

1.52

1.84

1.05

0.60

1.44

ITGB3

17q21.32

[23]

0.75

0.08

0.10

0.10

0.13

0.65

0.12

0.15

PF4

4q12-q21

[25]

0.90

0.06

0.06

0.11

0.12

0.44

0.13

0.25

PPBP

4q12-q13

[25]

1.45

0.10

0.07

0.13

0.09

0.28

0.34

0.44

TAL1

1p32

[23]

0.85

0.19

0.22

0.16

0.19

1.05

0.18

0.16

Chr21 genes

         

ADAMTS1

21q21.2

[49]

6.19

7.02

1.14

7.14

1.15

1.82

3.85

3.91

BACH1

21q22.11

[22]

1.86

1.44

0.77

1.04

0.56

1.55

0.93

0.67

DYRK1A

21q22.13

[50]

1.61

0.87

0.54

0.63

0.39

1.14

0.77

0.55

ERG

21q22.3

[18],[22]

0.68

3.47

5.12

3.10

4.57

1.42

2.44

2.18

ETS2

21q22.2

[18],[22]

0.93

1.11

1.20

1.39

1.49

0.73

1.52

1.90

GABPA

21q21.3

[18],[22]

1.39

2.45

1.76

1.52

1.10

1.55

1.58

0.98

RUNX1

21q22.3

[18],[22]

0.71

1.08

1.51

0.84

1.18

1.06

1.01

0.80

SOD1

21q22.11

[51]

1.88

1.52

0.81

2.78

1.48

1.52

1.00

1.84

SON

21q22.11

[22]

1.28

1.39

1.08

1.03

0.80

1.44

0.96

0.71

Other genes

APOC1

19q13.2

[20],[22],[23]

4.37

10.04

2.30

16.26

3.72

1.79

5.63

9.11

APOC2

19q13.2

[22]

4.36

37.04

8.49

43.48

9.96

1.43

25.88

30.37

APOE

19q13.2

[22],[23]

2.18

3.57

1.64

3.24

1.48

1.56

2.30

2.08

CDA

1p36.2-p35

[23]

0.39

0.40

1.03

0.88

2.24

0.88

0.46

1.00

DICER1

14q32.13

[18]

0.80

0.41

0.51

0.27

0.34

0.99

0.41

0.27

FCER1A

1q23

[22],[23]

6.32

4.28

0.68

8.86

1.40

1.32

3.25

6.72

GYPA

4q31.21

[23]

3.40

1.56

0.46

0.89

0.26

1.19

1.31

0.75

GYPB

4q31.21

[23]

2.81

1.28

0.46

0.89

0.31

1.27

1.01

0.70

GYPE

4q31.1

[23]

2.07

1.63

0.79

1.71

0.82

1.72

0.95

0.99

HDC

15q21-q22

[22],[23]

17.10

9.95

0.58

32.72

1.91

1.22

8.16

26.83

IGF1R

15q26.3

[17]

0.76

1.18

1.55

0.94

1.24

1.21

0.98

0.78

ITGAL

16p11.2

[52]

0.79

0.21

0.26

0.09

0.11

1.02

0.20

0.09

KIT

4q11-q12

[22]

1.66

3.34

2.01

3.08

1.85

1.22

2.74

2.53

MPL

1p34

[53]

1.11

0.31

0.28

0.22

0.20

1.23

0.25

0.18

MTOR

1p36.22

[17]

0.87

1.57

1.82

1.94

2.24

0.89

1.76

2.17

MYCN

2p24.3

[21]

0.35

1.00

2.87

0.77

2.19

0.34

2.99

2.28

PRAME

22q11.22

[21]

1.60

11.59

7.24

15.61

9.76

4.18

2.77

3.73

SMOX

20p13

[23]

1.37

0.76

0.55

1.02

0.75

0.79

0.96

1.30

ST18

8q11.23

[18]

0.90

0.74

0.82

0.74

0.82

0.78

0.96

0.95

  1. Expression values of genes known for their role in MK differentiation and DS or non-DS AMKL development in each of the eight comparisons: DS AMKL (pool 'A') vs. non-DS AMKL (pool 'B'); DS AMKL (pool 'A') vs. normal MK (pool 'D'); non-DS AMKL (pool 'B') vs. normal MK (pool 'D'); DS AMKL (pool 'A') vs. normal CB MK (pool 'E') cells; non-DS AMKL (pool 'B') vs. normal CB MK (pool 'E'); DS AMKL (pool 'A') vs. TMD (pool 'C'); TMD (pool 'C') vs. normal MK (pool 'D'); TMD (pool 'C') vs. normal CB MK (pool 'E'). Data extracted from the full tables showing expression values and their ratio for about 17-26,000 loci for each comparison. In bold: expression ratio values are consistent with data available in the literature (see references indicated). The other values are reported for completeness. Descriptions of the gene symbols are given in Additional file 2.
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BMC Medical Genomics

ISSN: 1755-8794

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