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Table 3 Significantly enriched pathways detected exclusively in week 8 and week 12 topiramate groups (n = 27)a

From: Transcriptome profiling and pathway analysis of genes expressed differentially in participants with or without a positive response to topiramate treatment for methamphetamine addiction

  Week 8 TPM Week 12 TPM
Pathway name b No. genes P Value FDR c No. genes P Value FDR c
Neuronal function / Synaptic plasticity ( n=8 )
Alpha-adrenergic signalinga 17 0.025 0.042 10 0.0036 0.029
Ephrin receptor signalinga 36 1.70 × 10−4 7.18 × 10−4 17 5.75 × 10−4 0.0095
ErbB signaling pathwayb 18 0.0026 0.0081 8 0.0078 0.035
FGF signalinga 18 0.0040 0.0086 8 0.017 0.074
GnRH signaling pathwayb 20 0.0017 0.0060 11 0.0012 0.013
mTOR signaling pathwayb 15 4.47 × 10−5 3.78 × 10−4 5 0.033 0.090
Neurotrophin/TRK signalinga 17 9.33 × 10−4 0.0027 7 0.017 0.074
Synaptic long term Potentiationa,b 29 6.17 × 10 6 7.44 × 10 5 10 0.012 0.058
Signal transduction ( n=6 )
Adipocytokine signalingb 14 0.0070 0.017 9 9.30 × 10−4 0.013
Fc Epsilon RI Signaling a,b 24 1.51 × 10 4 6.73 × 10 4 11 0.0018 0.021
LPS-stimulated MAPK signalinga 23 2.75 × 10−6 4.65 × 10−5 9 0.0025 0.024
NF-κB signalinga 33 3.02 × 10−5 2.04 × 10−4 14 0.0016 0.021
p38 MAPK signalinga 20 0.0037 0.0082 9 0.014 0.062
SAPK/JNK signalinga 18 0.011 0.021 14 1.35 × 10−5 5.56 × 10−4
Cardiovascular function ( n=2 )
Cardiac hypertrophy signalinga 42 2.45 × 10−4 9.22 × 10−4 16 0.013 0.062
Renin-angiotensin signalinga 27 3.55 × 10−5 2.24 × 10−4 14 8.91 × 10−5 0.0025
Inflammation / Immune function ( n=8 )
B cell activating factor signalinga 10 0.013 0.023 5 0.022 0.090
CCR3 signaling in eosinophilsa 24 0.0013 0.0035 13 5.25 × 10−4 0.0095
CCR5 signaling in macrophagesa 13 0.030 0.048 11 5.62 × 10−5 0.0019
Chemokine signalinga 21 4.37 × 10−5 2.54 × 10−4 8 0.0096 0.049
CXCR4 signalinga 28 0.0065 0.014 11 0.045 0.14
Epithelial cell signaling in Helicobacter pylori infectionb 16 0.0011 0.0048 8 0.0063 0.031
Natural killer cell signaling a,b 26 1.15 × 10 4 5.54 × 10 4 12 0.0013 0.019
Role of PKR in Interferon Induction and Antiviral Responsea 11 0.0051 0.011 5 0.025 0.094
Other ( n=3 )
Hepatic cholestasisa 24 0.014 0.026 12 0.0076 0.042
Macropinocytosisa 17 6.46 × 10−4 0.0021 8 0.0043 0.034
Xenobiotic metabolism signalinga 37 0.044 0.065 19 0.0053 0.036
  1. aIngenuity Pathways Knowledge Base Pathways with Number of Genes ≥ 3, P Values < 0.05, FDRs < 0.05 at either Week 8 or Week 12 and FDRs < 0.10 at both were selected by Ingenuity Pathway Analysis (IPA) URL: http://www.ingenuity.com/.
  2. bKyoto Encyclopedia of Genes and Genomes (KEGG) pathways with Number of Genes ≥ 3 and Gamma P Values < 0.05, and FDRs < 0.05 at either Week 8 or Week 12 and FDRs < 0.10 at both were selected by Onto-Tools URL: http://vortex.cs.wayne.edu/ontoexpress/. For pathways identified by both IPA and Onto-Tools (shown in italic), only IPA results were presented.
  3. cFDR, denoting false discovery rate, was estimated by the Benjamini-Hochberg (BH) method.