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Table 2 Clinical information of clinically nonfunctional pituitary adenoma and control pituitary samples

From: Heterogeneity analysis of the proteomes in clinically nonfunctional pituitary adenomas

Groups

Sample ID

Sex/Age

Clinical information

Immunohistochemistry

NF-NFPA

T164

M/35

Non-functional, visual loss, 3 × 3.5 × 4 cm. Partial hypopituitarism

Neg.

T217

M/39

Non-functional

Neg.

T219

M/68

Non-functional, 1.9 × 2.3 × 2.2 cm, invasion of the right cavernous sinus

Neg.

LH-NFPA

T208

F/47

Non-functional, 2 × 2 × 2 cm

LH 1-2+

T204

M/47

Non-functional

LH 3+

T237

F/40

Non-functional, right cavernous sinus extension

LH 2+

FSH-NFPA

T57

F/59

Non-functional, 2 × 3 cm

FSH 1+

T89

M/62

Non-functional, 2 × 2.3 × 2.3 cm

FSH 2+

T77

M/67

Non-functional, 2 × 2.2 × 2.4 cm, questionable cavernous sinus

FSH 2+

LH/FSH-NFPA

T65

F/54

Non-functional, 4 × 4 × 4 cm, cavernous sinus invasion

LH 2+, FSH 1+

T138

M/60

Non-functional, 2.9 × 3.1 × 3.5 cm

LH 2+, FSH 2+

T185

M/66

Non-functional, 2.8 ×, 2 × 2.4 cm. Bilateral cavernous sinus invasion

LH 2-3+, FSH 2-3+

Control pituitary (Con)

C2

M/27

Black, none

DNT

C3

F/40

White, Multiple toxic compounds. Blood: HepBb (+), HepC (+), HIV (−)

DNT

C4

M/45

White, Drowning. Blood alcohol = 3.1 g/L; no other drugs detected. Blood: HepB (+), HepC (+), HIV (−)

DNT

C5

M/36

White, Multiple toxic materials. Blood alcohol = 0.5 g/L. Blood: HepB (+), HepC (−), HIV (−)

DNT

C7

F/34

Black, Gunshot wound to chest. Blood alcohol = 0.3 g/L; no drugs. Blood: HepB (+), HepC (−), HIV (−)

DNT

C8

F

White, 15 h gunshot wound to head. No drugs or alcohol. Blood: HepB (−), HepC (−), HIV (−)

DNT

C9

M/55

White, 12 h gunshot wound to chest. No alcohol or drugs. Blood: HepB (−), HepC (−), HIV (−)

DNT

C10

F/47

White, Smoke inhalation. No drugs or alcohol. Numerous amylacea present in brain. Early autolytic changes to brain. Blood: HepB (−), HepC (+), HIV (−)

DNT

  1. Note: All those hormones (ACTH, LH, FSH, PRL, GH, and TSH) were immunohistochemisty-tested in each pituitary adenoma tissue. Neg. = Immunohistochemical stains for ACTH, LH, FSH, PRL, GH, and TSH were negative. LH+ = nonfunctional pituitary adenoma that expressed leuteinizing hormone, or lutropin; FSH+ = nonfunctional pituitary adenoma that expressed follicle-stimulating hormone, or follitropin; FSH+, LH+ = nonfunctional pituitary adenoma that expressed both follicle-stimulating hormone and leuteinizing hormone. Adenomas were graded blindly by a neuropathologist (from 0–4) for the intensity of staining for each peptide hormone. NFPA = nonfunctional pituitary adenoma. DNT = do not test.