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Table 2 Top categories enriched in association results for exacerbation phenotype (gene n = 999)

From: Identifying a gene expression signature of frequent COPD exacerbations in peripheral blood using network methods

GO category

ID

Genes in category

p-value

FDR q-value

Protein ubiquitination

GO:0016567

23

2.78E-008

4.42E-006

Purine ribonucleoside triphosphate catabolic process

GO:0009207

17

2.40E-006

4.78E-005

Guanosine-containing compound catabolic process

GO:1901069

16

1.04E-006

2.69E-005

Calcium ion homeostasis

GO:0055074

15

3.16E-007

1.68E-005

Epidermal growth factor receptor signaling pathway

GO:0007173

14

1.18E-007

9.37E-006

Cellular calcium ion homeostasis

GO:0006874

14

1.12E-006

2.69E-005

Activation of protein kinase activity

GO:0032147

10

2.68E-004

2.66E-003

Negative regulation of protein serine/threonine kinase activity

GO:0071901

9

9.97E-007

2.69E-005

KEGG category

ID

Genes in category

p-value

FDR q-value

Cell adhesion molecules (CAMs)

04514

13

3.86E-003

1.44E-001

B cell receptor signaling pathway

04662

11

2.72E-004

4.75E-002

T cell receptor signaling pathway

04660

11

5.62E-003

1.54E-001

Antigen processing and presentation

04612

10

1.23E-003

5.73E-002

Chagas disease (American trypanosomiasis)

05142

10

1.20E-002

2.23E-001

Primary immunodeficiency

05340

7

5.37E-004

4.75E-002

Allograft rejection

05330

7

7.66E-004

4.75E-002

Autoimmune thyroid disease

05320

7

5.81E-003

1.54E-001