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Table 2 Top categories enriched in association results for exacerbation phenotype (gene n = 999)

From: Identifying a gene expression signature of frequent COPD exacerbations in peripheral blood using network methods

GO category ID Genes in category p-value FDR q-value
Protein ubiquitination GO:0016567 23 2.78E-008 4.42E-006
Purine ribonucleoside triphosphate catabolic process GO:0009207 17 2.40E-006 4.78E-005
Guanosine-containing compound catabolic process GO:1901069 16 1.04E-006 2.69E-005
Calcium ion homeostasis GO:0055074 15 3.16E-007 1.68E-005
Epidermal growth factor receptor signaling pathway GO:0007173 14 1.18E-007 9.37E-006
Cellular calcium ion homeostasis GO:0006874 14 1.12E-006 2.69E-005
Activation of protein kinase activity GO:0032147 10 2.68E-004 2.66E-003
Negative regulation of protein serine/threonine kinase activity GO:0071901 9 9.97E-007 2.69E-005
KEGG category ID Genes in category p-value FDR q-value
Cell adhesion molecules (CAMs) 04514 13 3.86E-003 1.44E-001
B cell receptor signaling pathway 04662 11 2.72E-004 4.75E-002
T cell receptor signaling pathway 04660 11 5.62E-003 1.54E-001
Antigen processing and presentation 04612 10 1.23E-003 5.73E-002
Chagas disease (American trypanosomiasis) 05142 10 1.20E-002 2.23E-001
Primary immunodeficiency 05340 7 5.37E-004 4.75E-002
Allograft rejection 05330 7 7.66E-004 4.75E-002
Autoimmune thyroid disease 05320 7 5.81E-003 1.54E-001