Table 1 KEGG pathway enrichment analysis for the genes comprising signature 1 (101.6.1)

KEGG_PATHWAY

hsa04610:Complement and coagulation cascades

10

1.56

0

C1QA, FGG, A2M, C3, KLKB1, CD46, C1R, SERPING1, C1S, CFD

219

69

5085

3.37

0.33

0.33

2.97

KEGG_PATHWAY

hsa04540:Gap junction

10

1.56

0.01

TJP1, ADCY2, GNAI1, PDGFA, TUBB6, GUCY1A3, GJA1, LPAR1, PRKACB, ITPR2

219

89

5085

2.61

0.88

0.65

14.98

KEGG_PATHWAY

hsa04142:Lysosome

11

1.72

0.03

AGA, HGSNAT, LAMP2, CTSK, GM2A, PSAP, LGMN, CTSB, SCARB2, FUCA1, CLN5

219

117

5085

2.18

0.99

0.77

28.69

KEGG_PATHWAY

hsa04270:Vascular smooth muscle contraction

10

1.56

0.05

PLA2G4A, ADCY2, CALD1, MRVI1, GUCY1A3, PRKCH, PRKACB, PPP1CB, MYLK, ITPR2

219

112

5085

2.07

1

0.87

46.04

KEGG_PATHWAY

hsa04310:Wnt signaling pathway

12

1.88

0.06

CCND1, PRICKLE1, CCND2, BTRC, NFAT5, CAMK2D, TP53, MAPK10, PRKACB, FZD5, FZD4, FZD7

219

151

5085

1.85

1

0.85

51.51

KEGG_PATHWAY

hsa05330:Allograft rejection

5

0.78

0.07

HLA-DRB5, HLA-DPB1, HLA-E, HLA-DOA, HLA-DRA

219

36

5085

3.22

1

0.84

56.25

KEGG_PATHWAY

hsa05416:Viral myocarditis

7

1.1

0.08

CAV1, CCND1, HLA-DRB5, HLA-DPB1, HLA-E, HLA-DOA, HLA-DRA

219

71

5085

2.29

1

0.86

64.57

KEGG_PATHWAY

hsa05332:Graft-versus-host disease

5

0.78

0.08

HLA-DRB5, HLA-DPB1, HLA-E, HLA-DOA, HLA-DRA

219

39

5085

2.98

1

0.82

65.24

KEGG_PATHWAY

hsa04510:Focal adhesion

14

2.19

0.09

CAV1, PDGFA, MAPK10, FLNC, PPP1CB, VCL, CCND1, CCND2, ITGAV, COL6A2, RAP1A, THBS1, PIK3R1, MYLK

219

201

5085

1.62

1

0.81

67.5