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Table 2 Adipose tissue co-expression modules associated with insulin sensitivity (S I ) or other glucose homeostasis traits in Caucasians

From: Integrative network analysis reveals different pathophysiological mechanisms of insulin resistance among Caucasians and African Americans

Module (Module size)   S I Hub gene* (r, P) Module genes # associated with S I (r) AIRg HOMA-IR Matsuda Index BMI % Fat mass TG HDL GO Gene Category Overlap, P, Corrected-P
Tan (268) r 0.463 ANG (0.35, 0.0004) PFKFB3(0.53), LOC647276(0.52) −0.471 −0.572 0.525 −0.677 −0.523 −0.42 0.378 Enoyl-CoA hydratase activity
p 1.02E-04 6.92E-05 0.00243 1.33E-09 6.7E-13 4.1E-08 0.045 0.000132 3, 0.000046,NS
Thistle (88) r −0.531 ITGB5 (−0.41, <0.00001) PLAC9(−0.46), ITGB5(−0.44) 0.307 0.493 −0.459 0.662 0.522 0.467 −0.44 Cellular defense response
p 2.9E-06 0.00323 0.022 8.70E-07 1.7E-12 5E-08 0.003 0.0000328 6, 0.000039,NS
Yellow (1027) r −0.426 TYROBP (−0.37, 0.0002) KIAA1598(−0.53), ITGAV(−0.52) 0.286 0.384 −0.364 0.607 0.414 0.44 −0.414 Inflammatory response
p 4.95E-04 0.0493 0.113 0.000674 4E-09 3.72E-04 0.047 0.00045 93, 3.2E-30,1.7E-26
Hot pink (89) r −0.438 PTPN11 (−0.37, 0.0002) TMEM54(−0.44), SLC46A3(−0.4) 0.247 0.514 −0.444 0.593 0.436 0.421 −0.231 Substrate-bound cell migration
p 3.90E-04 0.00786 0.0353 7.82E-06 9.1E-08 6E-06 0.081 0.00741 4, 0.00025,NS
Peru (167) r −0.423 NQO1 (−0.43, <0.00001) GNG2(−0.53), UCHL1(−0.5) 0.198 0.475 −0.405 0.683 0.511 0.364 −0.262 Steroid metabolism
p 6.02E-04 0.0341 0.055 7.13E-05 1.5E-12 2E-08 0.038 0.00662 10, 0.0000059,0.031
Pink (359) r 0.411 SDHB (0.27, 0.0073) AZGP1(0.5), CKB(0.49) −0.306 −0.353 0.344 −0.491 −0.362 −0.36 0.418 Mitochondrion
p 3.53E-04 0.024 0.161 0.000372 9.7E-07 0.0002 0.032 0.00133 87, 3.6E-59,1.9E-55
Forest green (118) r −0.321 LOC728973 (0.30, 0.0022) SNCG(−0.35), CES2(−0.35) 0.272 0.418 −0.42 0.455 0.29 0.311 −0.182 Telomerase holoenzyme complex
p 0.0691 0.0535 0.198 0.00476 0.00222 0.0104 0.434 0.102 2, 0.00024,NS
Light yellow (186) r 0.413 DCI (0.39, <0.00001) ARHGEF16(0.44), HADH(0.43) −0.306 −0.336 0.323 −0.409 −0.269 −0.38 0.344 Mitochondrion
p 7.3E-06 0.00765 0.0767 2.68E-06 1.6E-05 0.00163 0.038 0.00238 27, 1.1E-11, 5.8E-08
  1. Large co-expression modules (>25 gene member) showing strong significant correlation (r > + or – 0.4, p <0.05 and FDR < 0.05) with insulin sensitivity (SI) or other OGTT- and FSIVGT-derived glucose homeostasis traits in Caucasians are shown. Correlation and significance of each module eigengenes with glucose homeostasis and other metabolic traits are shown. *gene showing highest TOM-based intramodular connectivity (to.in.norm), #top selected SI-associated genes shown (if direction matched with eigengene).