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Table 2 Adipose tissue co-expression modules associated with insulin sensitivity (S I ) or other glucose homeostasis traits in Caucasians

From: Integrative network analysis reveals different pathophysiological mechanisms of insulin resistance among Caucasians and African Americans

Module (Module size)

 

S I

Hub gene* (r, P)

Module genes # associated with S I (r)

AIRg

HOMA-IR

Matsuda Index

BMI

% Fat mass

TG

HDL

GO Gene Category Overlap, P, Corrected-P

Tan (268)

r

0.463

ANG (0.35, 0.0004)

PFKFB3(0.53), LOC647276(0.52)

−0.471

−0.572

0.525

−0.677

−0.523

−0.42

0.378

Enoyl-CoA hydratase activity

p

1.02E-04

6.92E-05

0.00243

1.33E-09

6.7E-13

4.1E-08

0.045

0.000132

3, 0.000046,NS

Thistle (88)

r

−0.531

ITGB5 (−0.41, <0.00001)

PLAC9(−0.46), ITGB5(−0.44)

0.307

0.493

−0.459

0.662

0.522

0.467

−0.44

Cellular defense response

p

2.9E-06

0.00323

0.022

8.70E-07

1.7E-12

5E-08

0.003

0.0000328

6, 0.000039,NS

Yellow (1027)

r

−0.426

TYROBP (−0.37, 0.0002)

KIAA1598(−0.53), ITGAV(−0.52)

0.286

0.384

−0.364

0.607

0.414

0.44

−0.414

Inflammatory response

p

4.95E-04

0.0493

0.113

0.000674

4E-09

3.72E-04

0.047

0.00045

93, 3.2E-30,1.7E-26

Hot pink (89)

r

−0.438

PTPN11 (−0.37, 0.0002)

TMEM54(−0.44), SLC46A3(−0.4)

0.247

0.514

−0.444

0.593

0.436

0.421

−0.231

Substrate-bound cell migration

p

3.90E-04

0.00786

0.0353

7.82E-06

9.1E-08

6E-06

0.081

0.00741

4, 0.00025,NS

Peru (167)

r

−0.423

NQO1 (−0.43, <0.00001)

GNG2(−0.53), UCHL1(−0.5)

0.198

0.475

−0.405

0.683

0.511

0.364

−0.262

Steroid metabolism

p

6.02E-04

0.0341

0.055

7.13E-05

1.5E-12

2E-08

0.038

0.00662

10, 0.0000059,0.031

Pink (359)

r

0.411

SDHB (0.27, 0.0073)

AZGP1(0.5), CKB(0.49)

−0.306

−0.353

0.344

−0.491

−0.362

−0.36

0.418

Mitochondrion

p

3.53E-04

0.024

0.161

0.000372

9.7E-07

0.0002

0.032

0.00133

87, 3.6E-59,1.9E-55

Forest green (118)

r

−0.321

LOC728973 (0.30, 0.0022)

SNCG(−0.35), CES2(−0.35)

0.272

0.418

−0.42

0.455

0.29

0.311

−0.182

Telomerase holoenzyme complex

p

0.0691

0.0535

0.198

0.00476

0.00222

0.0104

0.434

0.102

2, 0.00024,NS

Light yellow (186)

r

0.413

DCI (0.39, <0.00001)

ARHGEF16(0.44), HADH(0.43)

−0.306

−0.336

0.323

−0.409

−0.269

−0.38

0.344

Mitochondrion

p

7.3E-06

0.00765

0.0767

2.68E-06

1.6E-05

0.00163

0.038

0.00238

27, 1.1E-11, 5.8E-08

  1. Large co-expression modules (>25 gene member) showing strong significant correlation (r > + or – 0.4, p <0.05 and FDR < 0.05) with insulin sensitivity (SI) or other OGTT- and FSIVGT-derived glucose homeostasis traits in Caucasians are shown. Correlation and significance of each module eigengenes with glucose homeostasis and other metabolic traits are shown. *gene showing highest TOM-based intramodular connectivity (to.in.norm), #top selected SI-associated genes shown (if direction matched with eigengene).
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BMC Medical Genomics

ISSN: 1755-8794

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