Table 3 Adipose tissue co-expression modules associated with insulin sensitivity (S _I ) or other glucose homeostasis traits in African Americans

Black (441)

r

0.61

DCI

BCKDHA (0.7)

−0.39

−0.29

0.32

−0.52

−0.47

−0.05

0.01

Organic acid metabolism

p

0.001

(0.56,0.0003)

0.012

0.389

0.117

0.005

0.002

0.933

0.829

46, 1.2E-17,6.5E-14

Blue2 (39)

r

0.42

LOC392871

LOC340274 (0.44)

−0.27

−0.22

0.09

−0.71

−0.56

−0.06

0.24

Translational elongation

p

0.007

(0.44,0.0066)

0.017

0.472

0.241

9.530E-06

3.280E-04

0.594

0.226

2, 0.00034,NS

Brown2 (51)

r

0.29

NPLOC4

−0.41

−0.16

0.17

−0.20

−0.19

−0.03

−0.18

FGFR signaling pathway

p

0.271

(−0.4,0.0132)

0.027

0.030

0.133

0.165

0.260

0.837

0.307

2, 0.0026,NS

Burlywood (54)

r

0.50

LOC646672

THYN1 (0.55)

−0.49

−0.12

0.30

−0.28

−0.29

−0.19

0.03

Ribosome

p

0.013

(0.12,0.4803)

0.010

0.584

0.008

0.078

0.118

0.913

0.556

3, 0.00003,NS

Chartreuse (67)

r

0.26

DTWD1

−0.45

−0.04

0.10

0.03

0.00

−0.14

−0.27

Protein deubiquitination

p

0.109

(0.003,0.9878)

0.009

0.188

0.134

0.850

0.836

0.971

0.166

3, 0.00022,NS

Forest green (115)

r

−0.38

DCTN1

PCNXL3 (−0.48)

0.44

0.04

−0.10

0.15

0.03

−0.06

0.02

Drug transport

p

0.049

(−0.47,0.0031)

0.025

0.045

0.597

0.345

0.814

0.361

0.964

3, 0.00075,NS

Gold (147)

r

0.41

THYN1

LOC651198 (0.63)

−0.35

−0.26

0.19

−0.49

−0.47

−0.12

0.15

Cadherin-mediated cell adhesion

p

0.018

(0.52,0.0011)

0.019

0.212

0.005

0.001

0.007

0.728

0.774

4, 0.00066,NS

Green (618)

r

−0.56

FAM100A

AHCY (−0.72)

0.54

0.26

−0.36

0.27

0.29

0.14

0.02

Protein refolding

p

0.001

(−0.46,0.0043)

0.001

0.039

0.043

0.132

0.051

0.607

1.000

6, 0.000032,NS

Honeydew (69)

r

−0.43

C4orf18

VGLL3 (−0.56)

0.17

0.20

−0.24

0.58

0.65

0.24

−0.05

Mitochondrion

p

0.012

(−0.31,0.0659)

0.141

0.898

0.135

1.220E-04

4.320E-05

0.523

0.554

9, 0.000036,NS

Hot pink (93)

r

−0.42

MBD3

PIP5K1C (−0.55)

0.47

0.16

−0.25

0.21

0.19

0.06

0.00

Intracellular transport

p

0.034

(−0.5,0.0016)

0.019

0.025

0.131

0.213

0.252

0.649

0.803

15, 1.5E-06,0.0077

Light green (164)

r

−0.43

ZYX

MYO9B (−0.63)

0.21

0.31

−0.31

0.39

0.42

0.13

−0.34

Actin cytoskeleton organization and biogenesis

p

0.011

(−0.52,0.0009)

0.104

0.784

0.075

0.059

0.052

0.978

0.047

11, 0.000046,NS

Magenta (287)

r

−0.29

DPP3

TUBB2A (−0.57)

0.51

0.16

−0.22

0.16

0.22

0.12

0.22

Unsaturated fatty acid biosynthesis

p

0.124

(−0.32,0.0559)

0.006

0.034

0.081

0.617

0.212

0.718

0.211

4, 7.1E-07,0.0037

Midnight blue (186)

r

−0.58

ANXA1

SYNM (−0.71)

0.54

0.23

−0.34

0.41

0.42

0.26

−0.11

Nucleolus

p

4.050E-04

(−0.66,<0.00001)

3.870E-04

0.178

0.071

0.011

0.010

0.907

0.319

11, 3.7E-07,0019

Red (464)

r

0.58

LOC644315

LOC401676 (0.58)

−0.51

−0.26

0.28

−0.42

−0.39

−0.31

0.18

Ribosome

p

0.005

(0.41,0.0113)

0.003

0.250

0.045

0.007

0.012

0.632

0.536

24, 1.2E-26,6E-23

Seashell (124)

r

0.60

MOCS1

CNNM3 (0.62)

−0.46

−0.27

0.23

−0.61

−0.54

−0.06

−0.01

Alcohol metabolism

p

0.004

(0.52,0.001)

0.003

0.191

0.044

6.380E-05

4.050E-04

0.817

0.734

10, 1.7E-06,0.0088

Thistle (92)

r

−0.52

C1GALT1C1

RNF145 (−0.54)

0.45

0.28

−0.33

0.22

0.35

0.16

0.02

Antioxidant activity

p

0.015

(−0.49,0.002)

0.072

0.262

0.024

0.182

0.009

0.576

0.823

3, 0.0014,NS