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Table 3 Adipose tissue co-expression modules associated with insulin sensitivity (S I ) or other glucose homeostasis traits in African Americans

From: Integrative network analysis reveals different pathophysiological mechanisms of insulin resistance among Caucasians and African Americans

Module (Module size)   S I Hub gene* (r, P) Module genes# associated with S I (r) AIRg HOMA-IR Matsuda Index BMI PFAT TG HDL GO Gene Category Overlap, P, Corrected-P
Black (441) r 0.61 DCI BCKDHA (0.7) −0.39 −0.29 0.32 −0.52 −0.47 −0.05 0.01 Organic acid metabolism
p 0.001 (0.56,0.0003) 0.012 0.389 0.117 0.005 0.002 0.933 0.829 46, 1.2E-17,6.5E-14
Blue2 (39) r 0.42 LOC392871 LOC340274 (0.44) −0.27 −0.22 0.09 −0.71 −0.56 −0.06 0.24 Translational elongation
p 0.007 (0.44,0.0066) 0.017 0.472 0.241 9.530E-06 3.280E-04 0.594 0.226 2, 0.00034,NS
Brown2 (51) r 0.29 NPLOC4   −0.41 −0.16 0.17 −0.20 −0.19 −0.03 −0.18 FGFR signaling pathway
p 0.271 (−0.4,0.0132) 0.027 0.030 0.133 0.165 0.260 0.837 0.307 2, 0.0026,NS
Burlywood (54) r 0.50 LOC646672 THYN1 (0.55) −0.49 −0.12 0.30 −0.28 −0.29 −0.19 0.03 Ribosome
p 0.013 (0.12,0.4803) 0.010 0.584 0.008 0.078 0.118 0.913 0.556 3, 0.00003,NS
Chartreuse (67) r 0.26 DTWD1   −0.45 −0.04 0.10 0.03 0.00 −0.14 −0.27 Protein deubiquitination
p 0.109 (0.003,0.9878) 0.009 0.188 0.134 0.850 0.836 0.971 0.166 3, 0.00022,NS
Forest green (115) r −0.38 DCTN1 PCNXL3 (−0.48) 0.44 0.04 −0.10 0.15 0.03 −0.06 0.02 Drug transport
p 0.049 (−0.47,0.0031) 0.025 0.045 0.597 0.345 0.814 0.361 0.964 3, 0.00075,NS
Gold (147) r 0.41 THYN1 LOC651198 (0.63) −0.35 −0.26 0.19 −0.49 −0.47 −0.12 0.15 Cadherin-mediated cell adhesion
p 0.018 (0.52,0.0011) 0.019 0.212 0.005 0.001 0.007 0.728 0.774 4, 0.00066,NS
Green (618) r −0.56 FAM100A AHCY (−0.72) 0.54 0.26 −0.36 0.27 0.29 0.14 0.02 Protein refolding
p 0.001 (−0.46,0.0043) 0.001 0.039 0.043 0.132 0.051 0.607 1.000 6, 0.000032,NS
Honeydew (69) r −0.43 C4orf18 VGLL3 (−0.56) 0.17 0.20 −0.24 0.58 0.65 0.24 −0.05 Mitochondrion
p 0.012 (−0.31,0.0659) 0.141 0.898 0.135 1.220E-04 4.320E-05 0.523 0.554 9, 0.000036,NS
Hot pink (93) r −0.42 MBD3 PIP5K1C (−0.55) 0.47 0.16 −0.25 0.21 0.19 0.06 0.00 Intracellular transport
p 0.034 (−0.5,0.0016) 0.019 0.025 0.131 0.213 0.252 0.649 0.803 15, 1.5E-06,0.0077
Light green (164) r −0.43 ZYX MYO9B (−0.63) 0.21 0.31 −0.31 0.39 0.42 0.13 −0.34 Actin cytoskeleton organization and biogenesis
p 0.011 (−0.52,0.0009) 0.104 0.784 0.075 0.059 0.052 0.978 0.047 11, 0.000046,NS
Magenta (287) r −0.29 DPP3 TUBB2A (−0.57) 0.51 0.16 −0.22 0.16 0.22 0.12 0.22 Unsaturated fatty acid biosynthesis
p 0.124 (−0.32,0.0559) 0.006 0.034 0.081 0.617 0.212 0.718 0.211 4, 7.1E-07,0.0037
Midnight blue (186) r −0.58 ANXA1 SYNM (−0.71) 0.54 0.23 −0.34 0.41 0.42 0.26 −0.11 Nucleolus
p 4.050E-04 (−0.66,<0.00001) 3.870E-04 0.178 0.071 0.011 0.010 0.907 0.319 11, 3.7E-07,0019
Red (464) r 0.58 LOC644315 LOC401676 (0.58) −0.51 −0.26 0.28 −0.42 −0.39 −0.31 0.18 Ribosome
p 0.005 (0.41,0.0113) 0.003 0.250 0.045 0.007 0.012 0.632 0.536 24, 1.2E-26,6E-23
Seashell (124) r 0.60 MOCS1 CNNM3 (0.62) −0.46 −0.27 0.23 −0.61 −0.54 −0.06 −0.01 Alcohol metabolism
p 0.004 (0.52,0.001) 0.003 0.191 0.044 6.380E-05 4.050E-04 0.817 0.734 10, 1.7E-06,0.0088
Thistle (92) r −0.52 C1GALT1C1 RNF145 (−0.54) 0.45 0.28 −0.33 0.22 0.35 0.16 0.02 Antioxidant activity
p 0.015 (−0.49,0.002) 0.072 0.262 0.024 0.182 0.009 0.576 0.823 3, 0.0014,NS
  1. Large co-expression modules (>25 gene member) showing strong significant correlation (r > + or – 0.4, p <0.05 and FDR < 0.05) with insulin sensitivity (SI) or other OGTT- and FSIVGT-derived glucose homeostasis traits in African Americans are shown. Correlation and significance of each module eigengenes with glucose homeostasis and other metabolic traits are shown. *gene showing highest TOM-based intramodular connectivity (to.in.norm), #top selected SI-associated genes shown (if direction matched with eigengene).