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Table 5 Insulin sensitivity associated co-expression modules conserved in adipose tissue of both Caucasian and African American subjects

From: Integrative network analysis reveals different pathophysiological mechanisms of insulin resistance among Caucasians and African Americans

A. Conserved co-expression modules in CA subjects

CA Module (Module Size)

S I correlation (p; FDR)

FET p-value (Most Conserved w/ AA Module)

Enrichment for S I correlated genes (FET_P value)

GO Gene.Category (Module Overlap; FET_P)

All.corNeg

All.corPos

CA.corNeg

CA.corPos

AA.corNeg

AA.corPos

 

Blue2 (32)

−0.248 (2.15E-02, 1.24E-03)

2.99E-07 (yellow)

8.30E-05

1.00

1.06E-02

1.00

1.00

1.00

localization of cell (7; 5.90E-05)

Chartreuse (65)

0.221 (8.68E-02; 4.74E-03)

3.05E-38 (red)

1.00

5.68E-10

1.00

6.05E-03

1.00

4.47E-04

Ribosome (17; 7.20E-33)

Coral (183)

0.259 (9.25E-03;6.84E-04)

1.00E-44 (blue)

0.09

4.48E-05

0.96

4.13E-03

0.18

1.44E-05

RNA binding (16; 3.70E-06)

forest green (118)

−0.321 (6.91E-02; 1.38E-05)

2.55E-12 (burlywood)

0.10

1.12E-07

0.83

0.38

5.80E-08

0.17

telomerase holoenzyme complex (2; 2.40E-04)

Green (487)

0.337 (8.79E-03; 4.34E-06)

1.70E-27 (red)

0.75

1.05E-22

0.97

8.29E-24

1.00

1.08E-05

Ribosome (27; 5.60E-17)

Hot pink (89)

−0.438 (3.90E-04; 6.75E-10)

5.74E-13 (midnightblue)

3.52E-26

0.12

4.48E-02

0.75

2.70E-03

0.97

substrate-bound cell migration (4; 2.50E-04)

Khaki (134)

0.284 (7.48E-04; 1.59E-04)

6.96E-45 (chocolate)

1.00

1.66E-04

1.00

3.00E-16

1.00

0.83

lipid metabolism (39; 1.70E-25)

Light yellow (186)

0.413 (7.31E-06; 7.49E-09)

2.54E-20 (blue)

1.35E-02

7.30E-51

0.14

1.15E-09

1.00

0.69

Mitochondrion (27; 1.10E-11)

Peru (167)

−0.423 (6.02E-04; 2.91E-09)

2.92E-60 (red)

1.55E-46

1.00

3.53E-20

1.00

0.89

1.00

steroid metabolism (10; 5.90E-06)

Pink (359)

0.411 (3.53E-04; 9.01E-09)

9.87E-76 (lightcyan)

1.00

1.24E-45

1.00

3.90E-72

1.00

0.97

Mitochondrion (87; 3.60E-59)

Plum (96)

−0.264 (5.34E-02; 5.17E-04)

1.44E-11 (peru)

1.39E-08

0.94

7.61E-03

0.81

0.76

0.84

response to unfolded protein (4; 1.60E-04)

Red (432)

−0.218 (9.92E-01; 5.45E-03)

1.24E-235 (purple)

5.53E-04

1.00

7.56E-04

0.95

1.35E-04

1.00

cytoskeletal protein binding (40; 3.10E-15)

Seashell (135)

0.27 (1.53E-02; 3.66E-04)

4.64E-25 (green)

4.17E-03

1.15E-06

1.00

1.42E-02

0.98

5.34E-13

Proteasome (4; 1.50E-05)

Tan (268)

0.463 (1.02E-04; 5.21E-11)

6.18E-52 (seashell)

4.58E-02

3.32E-88

1.00

3.59E-18

1.00

0.55

enoyl-CoA hydratase activity (3; 4.60E-05)

Thistle (88)

−0.531 (2.89E-06; 2.22E-14)

1.22E-09 (red)

4.30E-10

2.56E-03

4.16E-02

7.11E-04

0.95

0.62

cellular defense response (6; 3.90E-05)

Yellow (1027)

−0.426 (4.95E-04; 2.18E-09)

5.01E-169 (turquoise)

8.05E-105

1.00

3.35E-167

1.00

1.00

1.00

inflammatory response (93; 3.20E-30)

B. Conserved co-expression modules in AA subjects

AA Module (Module Size)

S I correlation(p; FDR)

FET p-value (Most Conserved w/ CA Module)

Enrichment for S I correlated genes (FET_P value)

GO Gene.Category (Module Overlap; FET_P)

All.corNeg

All.corPos

CA.corNeg

CA.corPos

AA.corNeg

AA.corPos

 

Black (441)

0.609 (7.46E-04; 8.07E-07)

2.25E-36 (tan)

0.18

2.28E-101

1.00

1.25E-06

0.86

7.31E-14

organic acid metabolism (46; 1.20E-17)

Blue (1392)

0.359 (5.61E-02; 9.69E-03)

0 (blue)

0.56

6.30E-09

1.00

0.17

1.96E-03

8.27E-13

organelle membrane (93; 1.40E-13)

Burlywood (54)

0.502 (1.25E-02; 9.04E-05)

8.94E-19 (cyan)

0.72

1.73E-09

0.93

3.04E-02

0.95

1.28E-03

Ribosome (3; 3.00E-05)

Chocolate (133)

0.291 (5.73E-02; 4.75E-02)

6.96E-45 (khaki)

1.00

1.52E-04

1.00

5.72E-09

1.00

0.82

acetyl-CoA metabolism (10; 3.50E-16)

Gold (147)

0.41 (1.75E-02; 2.26E-03)

1.96E-11 (green)

1.00

1.70E-04

1.00

1.71E-02

0.96

2.29E-06

Cadherin-mediated cell adhesion (4; 6.60E-04)

Gray7 (26)

0.357 (6.88E-02; 1.02E-02)

4.32E-11 (hotpink)

1.00

8.61E-09

0.88

8.20E-04

0.76

0.80

DNA-dependent ATPase activity (2; 1.40E-04)

Green (618)

−0.562 (9.18E-04; 7.31E-06)

4.64E-25 (seashell)

6.30E-14

1.68E-12

1.00

1.00

6.09E-51

7.30E-29

protein refolding (6; 3.20E-05)

Honeydew (69)

−0.43 (1.23E-02; 1.20E-03)

3.05E-06 (green)

7.98E-08

1.47E-02

4.19E-02

0.11

0.31

0.40

mitochondrion (9; 3.60E-05)

Lightcyan (183)

0.397 (4.21E-03; 3.35E-03)

9.87E-76 (pink)

0.75

8.41E-29

0.86

7.09E-29

1.00

0.93

mitochondrion (35; 2.00E-21)

Lightgreen (164)

−0.43 (1.06E-02; 1.20E-03)

5.34E-67 (yellow)

4.15E-15

1.00

4.70E-19

1.00

0.17

1.00

actin cytoskeleton organization and biogenesis(11; 4.60E-05)

midnightblue (186)

−0.578 (4.05E-04; 3.53E-06)

5.74E-13 (hotpink)

3.36E-21

2.75E-03

1.00

0.97

6.66E-23

1.94E-05

nucleolus (11; 3.70E-07)

Red (464)

0.578 (4.51E-03; 3.53E-06)

2.92E-60 (peru)

2.37E-36

2.83E-06

0.75

0.99

1.12E-03

1.76E-08

Ribosome (24; 1.20E-26)

Seashell (124)

0.601(3.88E-03; 1.19E-06)

6.18E-52 (tan)

0.13

2.41E-53

1.00

6.97E-06

1.00

1.73E-02

alcohol metabolism (10; 1.70E-06)

Thistle (92)

−0.517(1.54E-02; 4.97E-05)

3.05E-07 (yellow)

8.67E-05

0.26

1.22E-02

0.64

0.06

0.81

antioxidant activity (3; 1.40E-03)

Turquoise (1980)

−0.315(4.74E-01; 2.84E-02)

5.01E-169 (yellow)

4.94E-23

1.00

5.89E-47

1.00

1.00

1.00

immune cell activation (82; 9.10E-18)

  1. All.corNeg/.corPos, Enrichment for genes that are negatively/positively correlated with SI in both AA and CA; CA.corNeg/.corPos; Enrichment for CA-specific genes that are negatively/positively correlated with SI; AA.corNeg/.corPos; Enrichment for AA-specific genes that are negatively/positively correlated with SI; FDR, False discovery rate; FET, Fisher’s exact test.
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BMC Medical Genomics

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