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Table 5 Insulin sensitivity associated co-expression modules conserved in adipose tissue of both Caucasian and African American subjects

From: Integrative network analysis reveals different pathophysiological mechanisms of insulin resistance among Caucasians and African Americans

A. Conserved co-expression modules in CA subjects
CA Module (Module Size) S I correlation (p; FDR) FET p-value (Most Conserved w/ AA Module) Enrichment for S I correlated genes (FET_P value) GO Gene.Category (Module Overlap; FET_P)
All.corNeg All.corPos CA.corNeg CA.corPos AA.corNeg AA.corPos  
Blue2 (32) −0.248 (2.15E-02, 1.24E-03) 2.99E-07 (yellow) 8.30E-05 1.00 1.06E-02 1.00 1.00 1.00 localization of cell (7; 5.90E-05)
Chartreuse (65) 0.221 (8.68E-02; 4.74E-03) 3.05E-38 (red) 1.00 5.68E-10 1.00 6.05E-03 1.00 4.47E-04 Ribosome (17; 7.20E-33)
Coral (183) 0.259 (9.25E-03;6.84E-04) 1.00E-44 (blue) 0.09 4.48E-05 0.96 4.13E-03 0.18 1.44E-05 RNA binding (16; 3.70E-06)
forest green (118) −0.321 (6.91E-02; 1.38E-05) 2.55E-12 (burlywood) 0.10 1.12E-07 0.83 0.38 5.80E-08 0.17 telomerase holoenzyme complex (2; 2.40E-04)
Green (487) 0.337 (8.79E-03; 4.34E-06) 1.70E-27 (red) 0.75 1.05E-22 0.97 8.29E-24 1.00 1.08E-05 Ribosome (27; 5.60E-17)
Hot pink (89) −0.438 (3.90E-04; 6.75E-10) 5.74E-13 (midnightblue) 3.52E-26 0.12 4.48E-02 0.75 2.70E-03 0.97 substrate-bound cell migration (4; 2.50E-04)
Khaki (134) 0.284 (7.48E-04; 1.59E-04) 6.96E-45 (chocolate) 1.00 1.66E-04 1.00 3.00E-16 1.00 0.83 lipid metabolism (39; 1.70E-25)
Light yellow (186) 0.413 (7.31E-06; 7.49E-09) 2.54E-20 (blue) 1.35E-02 7.30E-51 0.14 1.15E-09 1.00 0.69 Mitochondrion (27; 1.10E-11)
Peru (167) −0.423 (6.02E-04; 2.91E-09) 2.92E-60 (red) 1.55E-46 1.00 3.53E-20 1.00 0.89 1.00 steroid metabolism (10; 5.90E-06)
Pink (359) 0.411 (3.53E-04; 9.01E-09) 9.87E-76 (lightcyan) 1.00 1.24E-45 1.00 3.90E-72 1.00 0.97 Mitochondrion (87; 3.60E-59)
Plum (96) −0.264 (5.34E-02; 5.17E-04) 1.44E-11 (peru) 1.39E-08 0.94 7.61E-03 0.81 0.76 0.84 response to unfolded protein (4; 1.60E-04)
Red (432) −0.218 (9.92E-01; 5.45E-03) 1.24E-235 (purple) 5.53E-04 1.00 7.56E-04 0.95 1.35E-04 1.00 cytoskeletal protein binding (40; 3.10E-15)
Seashell (135) 0.27 (1.53E-02; 3.66E-04) 4.64E-25 (green) 4.17E-03 1.15E-06 1.00 1.42E-02 0.98 5.34E-13 Proteasome (4; 1.50E-05)
Tan (268) 0.463 (1.02E-04; 5.21E-11) 6.18E-52 (seashell) 4.58E-02 3.32E-88 1.00 3.59E-18 1.00 0.55 enoyl-CoA hydratase activity (3; 4.60E-05)
Thistle (88) −0.531 (2.89E-06; 2.22E-14) 1.22E-09 (red) 4.30E-10 2.56E-03 4.16E-02 7.11E-04 0.95 0.62 cellular defense response (6; 3.90E-05)
Yellow (1027) −0.426 (4.95E-04; 2.18E-09) 5.01E-169 (turquoise) 8.05E-105 1.00 3.35E-167 1.00 1.00 1.00 inflammatory response (93; 3.20E-30)
B. Conserved co-expression modules in AA subjects
AA Module (Module Size) S I correlation(p; FDR) FET p-value (Most Conserved w/ CA Module) Enrichment for S I correlated genes (FET_P value) GO Gene.Category (Module Overlap; FET_P)
All.corNeg All.corPos CA.corNeg CA.corPos AA.corNeg AA.corPos  
Black (441) 0.609 (7.46E-04; 8.07E-07) 2.25E-36 (tan) 0.18 2.28E-101 1.00 1.25E-06 0.86 7.31E-14 organic acid metabolism (46; 1.20E-17)
Blue (1392) 0.359 (5.61E-02; 9.69E-03) 0 (blue) 0.56 6.30E-09 1.00 0.17 1.96E-03 8.27E-13 organelle membrane (93; 1.40E-13)
Burlywood (54) 0.502 (1.25E-02; 9.04E-05) 8.94E-19 (cyan) 0.72 1.73E-09 0.93 3.04E-02 0.95 1.28E-03 Ribosome (3; 3.00E-05)
Chocolate (133) 0.291 (5.73E-02; 4.75E-02) 6.96E-45 (khaki) 1.00 1.52E-04 1.00 5.72E-09 1.00 0.82 acetyl-CoA metabolism (10; 3.50E-16)
Gold (147) 0.41 (1.75E-02; 2.26E-03) 1.96E-11 (green) 1.00 1.70E-04 1.00 1.71E-02 0.96 2.29E-06 Cadherin-mediated cell adhesion (4; 6.60E-04)
Gray7 (26) 0.357 (6.88E-02; 1.02E-02) 4.32E-11 (hotpink) 1.00 8.61E-09 0.88 8.20E-04 0.76 0.80 DNA-dependent ATPase activity (2; 1.40E-04)
Green (618) −0.562 (9.18E-04; 7.31E-06) 4.64E-25 (seashell) 6.30E-14 1.68E-12 1.00 1.00 6.09E-51 7.30E-29 protein refolding (6; 3.20E-05)
Honeydew (69) −0.43 (1.23E-02; 1.20E-03) 3.05E-06 (green) 7.98E-08 1.47E-02 4.19E-02 0.11 0.31 0.40 mitochondrion (9; 3.60E-05)
Lightcyan (183) 0.397 (4.21E-03; 3.35E-03) 9.87E-76 (pink) 0.75 8.41E-29 0.86 7.09E-29 1.00 0.93 mitochondrion (35; 2.00E-21)
Lightgreen (164) −0.43 (1.06E-02; 1.20E-03) 5.34E-67 (yellow) 4.15E-15 1.00 4.70E-19 1.00 0.17 1.00 actin cytoskeleton organization and biogenesis(11; 4.60E-05)
midnightblue (186) −0.578 (4.05E-04; 3.53E-06) 5.74E-13 (hotpink) 3.36E-21 2.75E-03 1.00 0.97 6.66E-23 1.94E-05 nucleolus (11; 3.70E-07)
Red (464) 0.578 (4.51E-03; 3.53E-06) 2.92E-60 (peru) 2.37E-36 2.83E-06 0.75 0.99 1.12E-03 1.76E-08 Ribosome (24; 1.20E-26)
Seashell (124) 0.601(3.88E-03; 1.19E-06) 6.18E-52 (tan) 0.13 2.41E-53 1.00 6.97E-06 1.00 1.73E-02 alcohol metabolism (10; 1.70E-06)
Thistle (92) −0.517(1.54E-02; 4.97E-05) 3.05E-07 (yellow) 8.67E-05 0.26 1.22E-02 0.64 0.06 0.81 antioxidant activity (3; 1.40E-03)
Turquoise (1980) −0.315(4.74E-01; 2.84E-02) 5.01E-169 (yellow) 4.94E-23 1.00 5.89E-47 1.00 1.00 1.00 immune cell activation (82; 9.10E-18)
  1. All.corNeg/.corPos, Enrichment for genes that are negatively/positively correlated with SI in both AA and CA; CA.corNeg/.corPos; Enrichment for CA-specific genes that are negatively/positively correlated with SI; AA.corNeg/.corPos; Enrichment for AA-specific genes that are negatively/positively correlated with SI; FDR, False discovery rate; FET, Fisher’s exact test.