Table 6 Ethnicity specific Insulin sensitivity associated co-expression modules
Module (Module Size) | SI correlation(p; FDR) | FET p-value(w/ Most Conserved Module) | Enrichment for SI correlated genes(FET_P value) | GO Gene.Category (Module Overlap; FET_P) | |||||
|---|---|---|---|---|---|---|---|---|---|
All.corNeg | All.corPos | CA.corNeg | CA.corPos | AA.corNeg | AA.corPos | ||||
CA specific modules | |||||||||
Bisque(121) | −0.323(3.59E-02; 1.20E-05) | 4.57E-40 | 0.67 | 1.00 | 1.85E-16 | 1.00 | 0.99 | 0.60 | response to virus (23; 6.70E-26) |
Blue3(25) | −0.325(5.49E-03; 1.04E-05) | 6.16E-06 | 0.33 | 1.00 | 1.02E-07 | 1.00 | 1.00 | 1.00 | endoplasmic reticulum (5; 4.40E-04) |
Darkcyan(63) | −0.325(1.06E-02; 1.04E-05) | 1.24E-09 | 0.57 | 0.95 | 8.09E-05 | 0.77 | 0.66 | 0.53 | cell junction (4; 1.60E-03) |
Gray7(15) | −0.264(6.88E-03; 5.17E-04) | 0.000124 | 1.00 | 1.00 | 5.46E-06 | 1.00 | 1.00 | 1.00 | adherens junction (2; 1.40E-04) |
Gray8(14) | 0.228(3.32E-03; 3.41E-03) | 1.67E-05 | 1.00 | 1.00 | 1.00 | 5.04E-05 | 1.00 | 0.58 | L-arginine transporter activity (1; 2.90E-03) |
AA specific modules | |||||||||
Forest green(115) | −0.38(4.94E-02; 5.47E-03) | 3.68E-18 | 0.79 | 0.79 | 1.00 | 0.84 | 1.05E-05 | 0.39 | drug transport (3; 7.50E-04) |
Gray10(24) | −0.433(6.29E-03; 1.09E-03) | 0.000413 | 0.68 | 1.00 | 0.86 | 1.00 | 2.21E-05 | 0.78 | vasculogenesis (2; 5.00E-04) |
Gray26(20) | 0.519(1.77E-03; 4.58E-05) | 0.000935 | 0.62 | 1.00 | 1.00 | 0.82 | 0.29 | 1.11E-05 | cellular catabolism (5; 5.30E-04) |
Gray80(12) | 0.6(1.21E-02; 1.25E-06) | 9.62E-06 | 0.44 | 0.44 | 1.00 | 1.00 | 1.00 | 6.77E-08 | UDP-N-acetylglucosaminebiosynthesis (1; 7.20E-04) |
Gray9(25) | 0.49(1.14E-03; 1.44E-04) | 0.0142 | 0.33 | 8.34E-04 | 0.87 | 1.00 | 2.51E-04 | 0.06 | regulation of small GTPasemediated signal transduction (2; 9.80E-04) |
Hot pink(93) | −0.415(3.39E-02; 1.93E-03) | 2.29E-05 | 0.14 | 0.64 | 0.94 | 1.00 | 3.08E-05 | 0.05 | intracellular transport (15; 1.50E-06) |
Lightyellow(152) | 0.391(2.63E-02; 3.99E-03) | 2.67E-15 | 1.00 | 0.99 | 0.98 | 1.00 | 3.32E-02 | 6.95E-09 | oxidoreductase activity, acting on superoxideradicals as acceptor (2; 2.90E-04) |
Plum(113) | −0.384(2.76E-02; 4.88E-03 | 5.67E-13 | 0.90 | 6.43E-03 | 0.95 | 0.83 | 5.02E-07 | 0.14 | small GTPase mediated signal transduction (10; 1.40E-05) |
Sienna(147) | 0.299(1.37E-01; 4.02E-02) | 1.61E-06 | 1.00 | 1.00 | 1.00 | 0.96 | 0.90 | 1.98E-04 | P-P-bond-hydrolysis-driven transporter activity (6; 5.60E-05) |