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Table 6 Ethnicity specific Insulin sensitivity associated co-expression modules

From: Integrative network analysis reveals different pathophysiological mechanisms of insulin resistance among Caucasians and African Americans

Module (Module Size) SI correlation(p; FDR) FET p-value(w/ Most Conserved Module) Enrichment for SI correlated genes(FET_P value) GO Gene.Category (Module Overlap; FET_P)
All.corNeg All.corPos CA.corNeg CA.corPos AA.corNeg AA.corPos
CA specific modules
Bisque(121) −0.323(3.59E-02; 1.20E-05) 4.57E-40 0.67 1.00 1.85E-16 1.00 0.99 0.60 response to virus (23; 6.70E-26)
Blue3(25) −0.325(5.49E-03; 1.04E-05) 6.16E-06 0.33 1.00 1.02E-07 1.00 1.00 1.00 endoplasmic reticulum (5; 4.40E-04)
Darkcyan(63) −0.325(1.06E-02; 1.04E-05) 1.24E-09 0.57 0.95 8.09E-05 0.77 0.66 0.53 cell junction (4; 1.60E-03)
Gray7(15) −0.264(6.88E-03; 5.17E-04) 0.000124 1.00 1.00 5.46E-06 1.00 1.00 1.00 adherens junction (2; 1.40E-04)
Gray8(14) 0.228(3.32E-03; 3.41E-03) 1.67E-05 1.00 1.00 1.00 5.04E-05 1.00 0.58 L-arginine transporter activity (1; 2.90E-03)
AA specific modules
Forest green(115) −0.38(4.94E-02; 5.47E-03) 3.68E-18 0.79 0.79 1.00 0.84 1.05E-05 0.39 drug transport (3; 7.50E-04)
Gray10(24) −0.433(6.29E-03; 1.09E-03) 0.000413 0.68 1.00 0.86 1.00 2.21E-05 0.78 vasculogenesis (2; 5.00E-04)
Gray26(20) 0.519(1.77E-03; 4.58E-05) 0.000935 0.62 1.00 1.00 0.82 0.29 1.11E-05 cellular catabolism (5; 5.30E-04)
Gray80(12) 0.6(1.21E-02; 1.25E-06) 9.62E-06 0.44 0.44 1.00 1.00 1.00 6.77E-08 UDP-N-acetylglucosaminebiosynthesis (1; 7.20E-04)
Gray9(25) 0.49(1.14E-03; 1.44E-04) 0.0142 0.33 8.34E-04 0.87 1.00 2.51E-04 0.06 regulation of small GTPasemediated signal transduction (2; 9.80E-04)
Hot pink(93) −0.415(3.39E-02; 1.93E-03) 2.29E-05 0.14 0.64 0.94 1.00 3.08E-05 0.05 intracellular transport (15; 1.50E-06)
Lightyellow(152) 0.391(2.63E-02; 3.99E-03) 2.67E-15 1.00 0.99 0.98 1.00 3.32E-02 6.95E-09 oxidoreductase activity, acting on superoxideradicals as acceptor (2; 2.90E-04)
Plum(113) −0.384(2.76E-02; 4.88E-03 5.67E-13 0.90 6.43E-03 0.95 0.83 5.02E-07 0.14 small GTPase mediated signal transduction (10; 1.40E-05)
Sienna(147) 0.299(1.37E-01; 4.02E-02) 1.61E-06 1.00 1.00 1.00 0.96 0.90 1.98E-04 P-P-bond-hydrolysis-driven transporter activity (6; 5.60E-05)
  1. All.corNeg/.corPos, Enrichment for genes that are negatively/positively correlated with SI in both AA and CA subjects; CA.corNeg/.corPos; Enrichment for CA-specific genes that are negatively/positively correlated with SI; AA.corNeg/.corPos; Enrichment for AA-specific genes that are negatively/positively correlated with SI; FDR, False discovery rate; FET, Fisher’s exact test.