Figure 5

Gene ontology terms are similar for mRNA targets of clinically relevant de-regulated miRNAs. (A) Illustrates the overlap in GO Biological Processes between targets of increased miRNA (in orange) and decreased miRNA (in blue) in HD. The x-axis shows the number of gene ontology terms that fall within a given semantic term set, and the y-axis lists the top twenty enriched terms for each set of miRNA targets. Darker colored points represent terms with higher significance and the size of the points represents the union of all genes that fall within a given the term. A number of terms, including “nervous system development” as well as terms relating to transcriptional regulation are shared across up- and down-regulated miRNA target groups. The similarity targets of up-regulated miRNA (in orange) and down-regulated miRNA (in blue) for GO Molecular Function are seen in (B) and for GO Cellular Component in (C).