Table 2 Differentially expressed miRNAs in Huntington’s disease prefrontal cortex
miRNA | Average expression | Original study, N=21 | Replication study, N=41 | Combined study, N=64 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
logFC | p-value | FDR q-value | logFC | p-value | FDR q-value | logFC | p-value | FDR q-value | ||
miR-10b-5p | 11.62 | 4.31 | 4.56E-11 | 4.28E-08 | 3.40 | 4.30E-12 | 1.35E-09 | 3.94 | 1.28E-20 | 1.20E-17 |
miR-196a-5p | 2.41 | 2.18 | 1.66E-09 | 7.80E-07 | 2.13 | 3.42E-12 | 1.35E-09 | 2.35 | 2.97E-20 | 1.39E-17 |
miR-615-3p | 1.95 | 1.28 | 1.69E-06 | 3.97E-04 | 1.73 | 2.56E-13 | 2.40E-10 | 1.59 | 2.33E-16 | 7.28E-14 |
miR-10b-3p | 2.02 | 1.37 | 4.64E-07 | 1.45E-04 | 1.15 | 2.93E-06 | 6.88E-04 | 1.45 | 2.13E-12 | 4.98E-10 |
miR-1298-3p | 7.05 | −0.56 | 1.72E-03 | 9.47E-02 | −0.80 | 1.09E-05 | 2.04E-03 | −0.78 | 5.52E-09 | 1.03E-06 |
miR-196b-5p | 2.56 | 1.05 | 7.62E-05 | 1.02E-02 | 1.06 | 9.34E-04 | 5.84E-02 | 1.31 | 2.33E-08 | 3.64E-06 |
miR-302a-3p | 2.28 | 0.64 | 6.22E-03 | 1.94E-01 | 0.84 | 3.57E-04 | 2.79E-02 | 0.81 | 3.72E-06 | 4.98E-04 |
miR-1247-5p | 6.18 | 0.90 | 2.05E-05 | 3.84E-03 | 0.46 | 7.81E-03 | 1.63E-01 | 0.62 | 8.47E-06 | 9.55E-04 |
miR-144-3p | 10.26 | 0.80 | 4.48E-02 | 3.73E-01 | 1.09 | 2.63E-04 | 2.47E-02 | 1.08 | 9.16E-06 | 9.55E-04 |
miR-223-3p | 8.46 | 0.49 | 3.95E-02 | 3.54E-01 | 0.94 | 6.20E-05 | 7.33E-03 | 0.75 | 1.94E-05 | 1.82E-03 |
miR-3200-3p | 9.75 | −0.25 | 8.48E-02 | 4.65E-01 | −0.29 | 4.20E-03 | 1.31E-01 | −0.32 | 4.85E-05 | 4.14E-03 |
miR-302a-5p | 2.99 | 0.52 | 2.86E-03 | 1.28E-01 | 0.62 | 1.97E-02 | 2.66E-01 | 0.70 | 5.70E-05 | 4.46E-03 |
miR-1264 | 5.00 | −0.24 | 1.09E-01 | 5.15E-01 | −0.69 | 3.87E-04 | 2.79E-02 | −0.53 | 9.49E-05 | 6.36E-03 |
miR-6734-5p | 2.79 | −0.34 | 1.89E-01 | 6.19E-01 | −1.16 | 1.63E-05 | 2.55E-03 | −0.79 | 8.86E-05 | 6.36E-03 |
miR-144-5p | 9.30 | 0.51 | 1.43E-01 | 5.71E-01 | 1.13 | 3.31E-04 | 2.79E-02 | 0.94 | 1.04E-04 | 6.53E-03 |
miR-138-2-3p | 6.08 | −0.44 | 3.59E-03 | 1.41E-01 | −0.29 | 3.24E-02 | 3.01E-01 | −0.38 | 1.43E-04 | 8.38E-03 |
miR-431-5p | 5.65 | −0.49 | 2.33E-02 | 3.09E-01 | −0.51 | 7.64E-03 | 1.63E-01 | −0.57 | 1.60E-04 | 8.84E-03 |
miR-132-3p | 12.93 | −0.48 | 1.57E-02 | 2.60E-01 | −0.43 | 2.72E-02 | 2.89E-01 | −0.54 | 1.99E-04 | 9.31E-03 |
miR-200c-3p | 3.84 | 0.46 | 3.97E-02 | 3.54E-01 | 0.26 | 1.12E-01 | 4.84E-01 | 0.48 | 1.97E-04 | 9.31E-03 |
miR-23b-5p | 3.18 | −0.30 | 8.92E-02 | 4.66E-01 | −0.62 | 2.02E-03 | 9.46E-02 | −0.55 | 1.81E-04 | 9.31E-03 |
miR-448 | 4.02 | −0.14 | 5.66E-01 | 8.91E-01 | −0.80 | 9.98E-05 | 1.04E-02 | −0.64 | 2.23E-04 | 9.96E-03 |
miR-486-3p | 4.84 | 0.54 | 7.85E-02 | 4.57E-01 | 0.79 | 4.16E-03 | 1.31E-01 | 0.78 | 2.76E-04 | 1.04E-02 |
miR-490-5p | 5.56 | −0.45 | 6.53E-02 | 4.34E-01 | −0.56 | 1.15E-02 | 2.12E-01 | −0.62 | 2.62E-04 | 1.04E-02 |
miR-5695 | 3.30 | 0.38 | 3.04E-02 | 3.28E-01 | 0.48 | 4.02E-03 | 1.31E-01 | 0.47 | 2.73E-04 | 1.04E-02 |
miR-885-5p | 10.46 | −0.31 | 5.23E-02 | 4.07E-01 | −0.27 | 3.12E-02 | 3.01E-01 | −0.35 | 2.77E-04 | 1.04E-02 |
miR-1224-5p | 8.08 | −0.39 | 3.89E-02 | 3.54E-01 | −0.53 | 4.83E-03 | 1.39E-01 | −0.49 | 3.83E-04 | 1.20E-02 |
miR-1298-5p | 6.43 | −0.80 | 9.80E-03 | 2.17E-01 | −0.65 | 3.24E-02 | 3.01E-01 | −0.81 | 3.84E-04 | 1.20E-02 |
miR-142-3p | 8.13 | 0.20 | 3.09E-01 | 7.41E-01 | 0.62 | 1.70E-03 | 8.39E-02 | 0.52 | 3.84E-04 | 1.20E-02 |
miR-346 | 8.21 | −0.31 | 6.05E-02 | 4.26E-01 | −0.27 | 1.74E-02 | 2.66E-01 | −0.32 | 3.71E-04 | 1.20E-02 |
miR-891a-5p | 5.84 | 0.79 | 5.16E-05 | 8.07E-03 | 0.18 | 3.68E-01 | 7.04E-01 | 0.50 | 3.69E-04 | 1.20E-02 |
miR-16-2-3p | 7.23 | 0.30 | 3.45E-01 | 7.53E-01 | 0.83 | 6.97E-04 | 4.67E-02 | 0.71 | 3.98E-04 | 1.21E-02 |
miR-363-3p | 11.07 | 0.39 | 1.08E-02 | 2.20E-01 | 0.30 | 2.71E-02 | 2.89E-01 | 0.34 | 4.14E-04 | 1.21E-02 |
miR-148a-3p | 13.01 | 0.69 | 1.70E-02 | 2.60E-01 | 0.47 | 7.34E-02 | 4.18E-01 | 0.69 | 4.57E-04 | 1.29E-02 |
miR-199a-5p | 7.66 | 0.69 | 3.46E-02 | 3.35E-01 | 0.66 | 4.30E-02 | 3.45E-01 | 0.82 | 4.66E-04 | 1.29E-02 |
miR-4449 | 3.25 | −0.96 | 1.83E-03 | 9.51E-02 | −0.86 | 5.21E-02 | 3.68E-01 | −1.09 | 5.28E-04 | 1.42E-02 |
miR-106a-5p | 6.28 | 0.52 | 9.97E-03 | 2.17E-01 | 0.40 | 3.15E-02 | 3.01E-01 | 0.44 | 5.64E-04 | 1.43E-02 |
miR-142-5p | 11.47 | 0.20 | 4.43E-01 | 8.36E-01 | 0.71 | 1.66E-03 | 8.39E-02 | 0.60 | 5.77E-04 | 1.43E-02 |
miR-549a | 3.25 | 0.57 | 9.95E-02 | 4.89E-01 | 0.86 | 1.84E-02 | 2.66E-01 | 0.95 | 5.67E-04 | 1.43E-02 |
miR-214-5p | 3.99 | 0.81 | 8.21E-03 | 2.12E-01 | 0.42 | 2.23E-01 | 5.96E-01 | 0.84 | 6.62E-04 | 1.59E-02 |
miR-141-3p | 5.43 | 0.48 | 1.12E-01 | 5.20E-01 | 0.34 | 2.00E-02 | 2.66E-01 | 0.47 | 8.05E-04 | 1.89E-02 |
miR-5680 | 5.39 | −0.20 | 1.92E-01 | 6.23E-01 | −0.41 | 5.42E-03 | 1.40E-01 | −0.35 | 9.93E-04 | 2.27E-02 |
miR-3065-5p | 6.04 | 0.37 | 1.10E-01 | 5.15E-01 | 0.40 | 6.86E-03 | 1.57E-01 | 0.42 | 1.04E-03 | 2.33E-02 |
miR-224-5p | 4.95 | 0.71 | 5.90E-02 | 4.20E-01 | 0.82 | 1.98E-02 | 2.66E-01 | 0.88 | 1.19E-03 | 2.60E-02 |
miR-4787-3p | 5.94 | −0.25 | 1.84E-01 | 6.15E-01 | −0.30 | 1.29E-02 | 2.23E-01 | −0.33 | 1.23E-03 | 2.62E-02 |
miR-452-5p | 4.76 | 0.32 | 2.06E-01 | 6.41E-01 | 0.68 | 2.02E-02 | 2.66E-01 | 0.67 | 1.29E-03 | 2.69E-02 |
miR-129-1-3p | 9.79 | −0.42 | 3.13E-02 | 3.33E-01 | −0.28 | 5.47E-02 | 3.79E-01 | −0.38 | 1.36E-03 | 2.76E-02 |
miR-4443 | 5.69 | 0.92 | 1.10E-02 | 2.20E-01 | 0.41 | 1.54E-01 | 5.39E-01 | 0.75 | 1.39E-03 | 2.77E-02 |
miR-101-5p | 9.55 | 0.30 | 2.49E-02 | 3.11E-01 | 0.20 | 1.08E-01 | 4.74E-01 | 0.28 | 1.47E-03 | 2.88E-02 |
miR-483-5p | 4.39 | 1.03 | 5.31E-02 | 4.07E-01 | 0.78 | 8.24E-02 | 4.31E-01 | 1.16 | 1.52E-03 | 2.91E-02 |
miR-2114-5p | 3.41 | 0.39 | 3.34E-02 | 3.33E-01 | 0.29 | 1.85E-01 | 5.72E-01 | 0.48 | 1.65E-03 | 3.09E-02 |
miR-1185-1-3p | 5.32 | −0.24 | 2.34E-01 | 6.71E-01 | −0.43 | 8.49E-03 | 1.67E-01 | −0.41 | 1.70E-03 | 3.12E-02 |
miR-670-3p | 6.70 | −0.46 | 5.50E-02 | 4.13E-01 | −0.39 | 7.24E-02 | 4.18E-01 | −0.52 | 1.77E-03 | 3.19E-02 |
miR-129-5p | 12.39 | −0.13 | 3.31E-01 | 7.47E-01 | −0.50 | 3.31E-03 | 1.20E-01 | −0.35 | 1.95E-03 | 3.22E-02 |
miR-135b-5p | 4.45 | −0.49 | 1.70E-02 | 2.60E-01 | −0.44 | 5.58E-02 | 3.82E-01 | −0.52 | 1.97E-03 | 3.22E-02 |
miR-194-5p | 8.77 | 0.23 | 8.25E-02 | 4.64E-01 | 0.32 | 3.68E-02 | 3.29E-01 | 0.33 | 1.99E-03 | 3.22E-02 |
miR-208b-3p | 6.41 | 0.46 | 1.10E-02 | 2.20E-01 | 0.28 | 7.05E-02 | 4.18E-01 | 0.36 | 1.89E-03 | 3.22E-02 |
miR-4488 | 2.97 | −1.38 | 3.79E-04 | 3.24E-02 | −0.91 | 1.35E-01 | 5.16E-01 | −1.32 | 1.96E-03 | 3.22E-02 |
miR-888-5p | 2.83 | 0.56 | 3.39E-02 | 3.35E-01 | 0.39 | 7.20E-02 | 4.18E-01 | 0.56 | 1.91E-03 | 3.22E-02 |
miR-126-5p | 15.88 | 0.41 | 2.59E-02 | 3.16E-01 | 0.23 | 6.10E-02 | 4.03E-01 | 0.29 | 2.46E-03 | 3.88E-02 |
miR-34c-5p | 9.25 | −1.09 | 6.77E-04 | 4.75E-02 | −0.40 | 1.41E-01 | 5.26E-01 | −0.64 | 2.48E-03 | 3.88E-02 |
miR-218-1-3p | 6.08 | 0.30 | 5.80E-02 | 4.20E-01 | 0.39 | 2.29E-02 | 2.76E-01 | 0.35 | 2.53E-03 | 3.89E-02 |
miR-150-5p | 10.20 | 0.42 | 2.03E-02 | 2.84E-01 | 0.33 | 6.04E-02 | 4.02E-01 | 0.39 | 2.74E-03 | 4.11E-02 |
miR-486-5p | 14.08 | 0.70 | 7.24E-02 | 4.52E-01 | 0.66 | 4.08E-02 | 3.39E-01 | 0.75 | 2.76E-03 | 4.11E-02 |
miR-433-3p | 10.55 | −0.01 | 9.48E-01 | 9.91E-01 | −0.36 | 1.23E-03 | 7.24E-02 | −0.24 | 2.85E-03 | 4.18E-02 |
miR-219b-3p | 3.11 | −0.46 | 1.89E-02 | 2.78E-01 | −0.24 | 3.09E-01 | 6.46E-01 | −0.47 | 3.05E-03 | 4.40E-02 |
miR-548n | 2.82 | 0.09 | 6.44E-01 | 9.27E-01 | 0.64 | 6.41E-03 | 1.50E-01 | 0.52 | 3.14E-03 | 4.46E-02 |
miR-663b | 2.20 | −0.73 | 1.49E-02 | 2.59E-01 | −0.59 | 9.97E-02 | 4.58E-01 | −0.81 | 3.21E-03 | 4.50E-02 |
miR-148a-5p | 6.67 | 0.46 | 4.67E-02 | 3.81E-01 | 0.44 | 7.58E-02 | 4.18E-01 | 0.52 | 3.31E-03 | 4.57E-02 |
miR-29a-3p | 15.37 | 0.20 | 1.33E-01 | 5.56E-01 | 0.22 | 4.17E-02 | 3.40E-01 | 0.23 | 3.46E-03 | 4.70E-02 |
miR-320b | 5.63 | 1.13 | 1.69E-02 | 2.60E-01 | 0.56 | 1.93E-01 | 5.78E-01 | 0.97 | 3.54E-03 | 4.74E-02 |
miR-181a-3p | 12.15 | −0.43 | 2.97E-02 | 3.26E-01 | −0.29 | 9.44E-02 | 4.51E-01 | −0.38 | 3.60E-03 | 4.75E-02 |
miR-153-5p | 7.32 | 0.55 | 7.08E-03 | 2.05E-01 | 0.22 | 1.80E-01 | 5.72E-01 | 0.37 | 3.78E-03 | 4.79E-02 |
miR-28-5p | 10.13 | 0.24 | 1.37E-01 | 5.65E-01 | 0.22 | 6.84E-02 | 4.14E-01 | 0.27 | 3.75E-03 | 4.79E-02 |
miR-7-2-3p | 6.06 | 0.25 | 8.90E-02 | 4.66E-01 | 0.26 | 4.67E-02 | 3.59E-01 | 0.27 | 3.78E-03 | 4.79E-02 |
miR-877-5p | 7.14 | −0.28 | 1.28E-01 | 5.50E-01 | −0.29 | 2.07E-02 | 2.66E-01 | −0.28 | 3.88E-03 | 4.85E-02 |
miR-3687 | 4.14 | −1.37 | 3.47E-04 | 3.24E-02 | −0.77 | 1.96E-01 | 5.78E-01 | −1.20 | 4.25E-03 | 5.17E-02 |
miR-4516 | 3.82 | −1.29 | 3.03E-04 | 3.16E-02 | −0.77 | 1.72E-01 | 5.61E-01 | −1.13 | 4.42E-03 | 5.24E-02 |
miR-3139 | 3.01 | −0.82 | 4.64E-04 | 3.63E-02 | 0.00 | 9.86E-01 | 9.94E-01 | −0.48 | 9.64E-03 | 8.37E-02 |
miR-663a | 2.56 | −1.02 | 1.61E-04 | 1.89E-02 | −0.46 | 3.60E-01 | 6.98E-01 | −0.86 | 1.40E-02 | 1.04E-01 |
miR-34b-3p | 5.11 | −0.92 | 7.09E-04 | 4.75E-02 | −0.24 | 3.87E-01 | 7.16E-01 | −0.49 | 1.77E-02 | 1.20E-01 |
miR-1538 | 2.63 | 0.20 | 3.04E-01 | 7.41E-01 | −0.70 | 6.26E-05 | 7.33E-03 | −0.21 | 1.30E-01 | 3.68E-01 |