Figure 5
From: BMP2 response pattern in human lung fibroblasts predicts outcome in lung adenocarcinomas
Prognostic significance of the “Fibroblast specific BMP2 induced gene list” in human lung adenocarcinomas. Unsupervised hierarchical clustering of the genes in the “Fibroblast specific BMP2 induced gene list” in the Garber and the Lee datasets. (A) The expression values of genes in the “Fibroblast specific BMP2 induced gene list” were extracted from a published study of genes expressed in 41 lung adenocarcinomas. The genes are presented in rows and experiments, in columns. The “Fibroblast specific BMP2 induced gene list” stratifies lung adenocarcinomas into two groups. The Kaplan-Meier curve on the lower panel represents the clinical outcome of the patients with tumors exhibiting high (underlined in black) and low expression levels (underlined in red) of genes in the “Fibroblast specific BMP2 induced gene list”. (B) Expression of the “Fibroblast specific BMP2 induced gene list” in stage I lung adenocarcinomas published by Lee et al. Again, the “Fibroblast specific BMP2 induced gene list” segregates lung adenocarcinomas into two groups which have significantly different clinical outcomes as shown by the Kaplan-Meier curves of overall survival.