Derivation of a bronchial genomic classifier for lung cancer in a prospective study of patients undergoing diagnostic bronchoscopy

Table 1 Clinical and demographic characteristics of the patients used to train the classifier

Category	Sub-category	Lung cancer	Benign disease	p
N		223	76
Sex	Female	97	26	0.178
	Male	126	50
Age (median years)		65	56	<0.001
Race	Caucasian	168	59	0.757
	African-American	47	13
	Other	5	3
	Unknown	3	1
Smoking status	Current	101	26	0.107
	Former	122	50
Smoking history (median PY)		43	30	<0.001
Mass size	<2 cm	46	23	<0.001
	>2 to <3 cm	30	12
	≥3 cm	122	19
	ill-defined infiltrate	10	13
	Unknown	15	9
Mass location	Central	86	16	0.018
	Peripheral	60	30
	Central & peripheral	60	18
	Unknown	17	12
Histology	Sub-type
SCLC		40
NSCLC		180
	Adenocarcinoma	83
	Squamous	73
	Large cell	6
	Mixed/undefined	18
Unknown		3
Histology	Stage
SCLC	Limited	16
	Extensive	18
	Unknown	6
NSCLC	1	28
	2	16
	3	42
	4	62
	Unknown	32
Benign disease	Sub-category
Alternative diagnosis			54
	Infection		23
	Sarcoid		14
	Inflammation		7
	Fibrosis		4
	Other		4
	Benign growths		2
Resolution/Stability			22

The classifier training set included 223 patients diagnosed with lung cancer and 76 patients diagnosed with benign disease. The table lists clinical and demographic factors for all patients in the training set as well as characteristics of the lung cancer positive and patients with benign disease. The p-value for race is calculated for Caucasian versus non-caucasian.

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