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Table 3 Performance of bronchoscopy, classifier, and the combined procedures in the test set

From: Derivation of a bronchial genomic classifier for lung cancer in a prospective study of patients undergoing diagnostic bronchoscopy

Category Bronchoscopy Classifier * Classifier & bronchoscopy combined
N, total 163 123 163
N, Lung cancer 78 38 78
N, Benign disease 85 85 85
Sensitivity (95% CI) 51% (40-62%) 92% (78-98%) 96% (89-99%)
Specificity (95% CI) 100% (95-100%) 53% (42-63%) 53% (42-63%)
NPV (95% CI) 69% (60-77%) 94% (83-98%) 94% (83-98%)
PPV (95% CI) 100% (90-100%) 47% (36-58%) 65% (56-73%)
  1. *The performance of the classifier was evaluated in patients in which bronchoscopy did not result in a finding of cancer (n = 123).