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Table 2 Ingenuity pathway analysis (IPA) results a) Family 1 b) Family 2 c) Subset of 27 genes found in both affected twins

From: DNA methylation differences in monozygotic twin pairs discordant for schizophrenia identifies psychosis related genes and networks

a. Family 1
Biological function P-value Genes
Diseases and disorders
Developmental Disorder 3.93E-03 - 3.21E-02 10
Hereditary Disorder 3.93E-03 - 4.58E-02 19
Skeletal and Muscular Disorders 3.93E-03 - 3.21E-02 5
Neurological Disease 4.77E-03 - 3.54E-02 13
Molecular and cellular functions
Carbohydrate Metabolism 7.88E-04 - 2.06E-02 3
Lipid Metabolism 7.88E-04 - 2.06E-02 3
Small Molecule Biochemistry 7.88E-04 - 4.58E-02 7
Gene Expression 2.63E-03 - 4.58E-02 18
Cell Death and Survival 5.20E-03 - 3.16E-02 13
Canonical pathways
Human Embryonic Stem Cell Pluripotency 6.45E-05 6/149 (0.04)
Tec Kinase Signaling 1.51E-04 6/175 (0.034)
Sphingosine-1-phosphate Signaling 2.42E-03 4/115 (0.035)
Renal Cell Carcinoma Signaling 5.55E-03 3/71 (0.042)
IL-4 Signaling 6.49E-03 3/75 (0.04)
Physiological system development and function
Cardiovascular System Development and Function 5.20E-03 - 3.58E-02 1
Hair and Skin Development and Function 5.20E-03 - 4.58E-02 2
Hematological System Development and Function 5.20E-03 - 4.13E-02 7
Immune Cell Trafficking 5.20E-03 - 4.13E-02 3
Associated network functions
Cell Death and Survival, Cellular Movement, Cellular Function and Maintenance Score = 19
Cellular Movement, Immune Cell Trafficking, Hematological System Development and Function Score = 17
Hereditary Disorder, Skeletal and Muscular Disorders, Developmental Disorder Score = 9
Connective Tissue Disorders, Dermatological Diseases and Conditions, Hematological System Development and Function Score = 2
Organ Morphology, Reproductive System Development and Function, Cellular Function and Maintenance Score = 2
b. Family 2
Cancer 2.09E-04 - 4.07E-02 204
Gastrointestinal Disease 8.86E-04 - 4.07E-02 29
Organismal Injury and Abnormalities 9.34E-04 - 3.94E-02 46
Skeletal and Muscular Disorders 9.34E-04 - 4.07E-02 36
Molecular and cellular functions
Lipid Metabolism 1.88E-04 - 4.07E-02 7
Molecular Transport 1.88E-04 - 4.07E-02 9
Small Molecule Biochemistry 1.88E-04 - 4.07E-02 19
Cellular Growth and Proliferation 3.06E-04 - 4.07E-02 21
Cell Morphology 5.59E-04 - 3.63E-02 10
Canonical pathways
Hepatic Cholestasis 1.05E-04 9/141(0.064)
Granzyme A Signaling 1.51E-03 3/17 (0.176)
Ovarian Cancer Signaling 2.24E-03 7/138 (0.051)
STAT3 Pathway 3.31E-03 5/74 (0.068)
Colorectal Cancer Metastasis Signaling 4.9E-03 9/244 (0.037)
Physiological system development and function
Cardiovascular System Development and Function 1.88E-04 - 4.07E-02 10
Digestive System Development and Function 1.88E-04 - 1.88E-04 2
Embryonic Development 1.88E-04 - 4.07E-02 14
Organ Development 1.88E-04 - 4.07E-02 6
Associated network functions
Cell Death and Survival, Cellular Development, Connective Tissue Development and Function Score = 39
Cellular Movement, Immune Cell Trafficking, Hematological System Development and Function Score = 12
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease Score = 11
Cell Death and Survival, Cellular Movement, Renal Necrosis/Cell Death Score = 11
Cell Morphology, Cellular Function and Maintenance, Cell Cycle Score = 9
c. Shared DMRs between both families
Cancer 4.03E-04 - 4.50E-02 5
Connective Tissue Disorders 4.03E-04 - 8.05E-04 1
Developmental Disorder 4.03E-04 - 1.21E-03 1
Endocrine System Disorders 4.03E-04 - 4.50E-02 2
Molecular and cellular functions
Cell Signaling 4.03E-04 - 3.73E-02 1
Nucleic Acid Metabolism 4.03E-04 - 3.73E-02 1
Small Molecule Biochemistry 4.03E-04 - 3.73E-02 1
Gene Expression 3.62E-03 - 9.63E-03 1
Cellular Movement 6.43E-03 - 6.43E-03 1
Canonical pathways
Protein Kinase A Signaling 3.09E-04 3/368 (0.008)
Granzyme A Signaling 6.83E-03 1/17 (0.059)
G Protein Signaling Mediated by Tubby 1.24E-02 1/31 (0.032)
Serotonin Receptor Signaling 1.72E-02 1/43 (0.023)
UVB-Induced MAPK Signaling 2.12E-02 1/53 (0.019)
Physiological system development and function
Nervous System Development and Function 1.61E-03 - 1.61E-03 1
Hematological System Development and Function 6.43E-03 - 2.47E-02 1
Immune Cell Trafficking 6.43E-03 - 6.43E-03 1
Behavior 2.04E-02 - 2.04E-02 1
Associated network functions
Infectious Disease, Cancer, Gastrointestinal Disease Score = 3
Tissue Morphology, Organismal Survival, Gene Expression Score = 3
Hereditary Disorder, Gene Expression, Embryonic Development Score = 3
DNA Replication, Recombination, and Repair, Gene Expression, Cancer Score = 3
Cell Death and Survival, Cellular Function and Maintenance, Connective Tissue Development and Function Score = 3