Table 2 Diseases over-represented among the 228 gene set

Cancer or viral infections

C = 951;O = 25;E = 4.90;R = 5.11; p = 3.35e-11;adjP = 8.71e-10

RARA, WIF1, AKT1, LGALS3, RB1CC1, E2F3, FH, SPHK1,

DCT, FOS, BID, PDGFA, CD24, S100A7, EPHA2, PMAIP1,

SMO, RHOBTB2, CTNND1, SPI1, ETV1, ALDH1A1, CEACAM1, HDAC2, MYB

Neoplasms

C = 854;O = 22;E = 4.40;R = 5.00; p = 7.90e-10;adjP = 1.03e-08

RARA, WIF1, AKT1, LGALS3, E2F3, FH, DCT, PDGFA, CD24,

S100A7, EPHA2, PMAIP1, FLT1, SMO, RHOBTB2, CTNND1, SSTR1, SPI1, ETV1, ALDH1A1, CEACAM1, MYB

Drug interaction with drug

C = 349;O = 13;E = 1.80;R = 7.24; p = 4.00e-08;adjP = 3.47e-07

CEBPB, PPIB, KPNA4, RARA, AKT1, PMAIP1, ITGA2, ACTA1, PACS1, STX4, FOS, BID, HDAC2

HIV

C = 755;O = 18;E = 3.89;R = 4.63; p = 9.30e-08;adjP = 6.04e-07

ADARB1, PPIB, KHDRBS1, MGAT4B, FURIN, PSMD7, PACS1,

FOS, EED, PIK3C2A, CEBPB, PSMB10, KPNA4, MANEA, DDX6, ACTA1, GTF2H1, HLA-DOA

Bipolar disorder

C = 344;O = 12;E = 1.77;R = 6.78; p = 2.71e-07;adjP = 1.41e-06

IMPA1, ATF4, DUSP6, CACNA1C, MDGA1, CTSF, CIT, PDE4B, FEZ1, NLGN1, NTF3, ADRBK2

Infection

C = 516;O = 14;E = 2.66;R = 5.27; p = 5.72e-07;adjP = 2.48e-06

MIF, PSMB10, PPIB, KPNA4, TBK1, MICB, FURIN, PACS1, NKRF, IL13RA1, TICAM1, HLA-DOA, CEACAM1, PIK3C2A

Metabolic diseases

C = 612;O = 15;E = 3.15;R = 4.76; p = 8.02e-07;adjP = 2.61e-06

PC, PEX6, JAZF1, CST3, CPOX, TOP3A, APOA2, NEFH, ADIPOR2, PYGL, LIPA, AGL, APOA1, BCL11A, ZMPSTE24

Leukemia

C = 452;O = 13;E = 2.33;R = 5.59; p = 7.65e-07;adjP = 2.61e-06

RCBTB1, RARA, ASNS, AKT1, HUWE1, PMAIP1, PRDM16, DOK1, CASC5, BID, SPI1, BCL11A, MYB

Stress

C = 464;O = 13;E = 2.39;R = 5.44; p = 1.02e-06;adjP = 2.95e-06

ASNS, ATF4, MTF1, AKT1, PMAIP1, MICB, ACTA1, SGK1, CHUK, MAP3K5, FOS, PRDX4, RPL11

Mental disorders

C = 564;O = 14;E = 2.90;R = 4.82; p = 1.62e-06;adjP = 3.79e-06

NDEL1, CACNA1C, MDGA1, ASPM, BACE1, CST3, PDE4B, NEFH, FEZ1, NLGN1, NTF3, ADRBK2, CDK5R1, ADRA2A

Adhesion

C = 647;O = 15;E = 3.33;R = 4.50; p = 1.59e-06;adjP = 3.79e-06

TEK, CD24, AKT1, LGALS3, EPHA2, RB1CC1, MDGA1, ITGA2,

ACTA1, CADM3, PTPN12, NLGN1, CTNND1, CEACAM1, CLDN11

Neoplastic processes

C = 411;O = 12;E = 2.12;R = 5.67; p = 1.75e-06;adjP = 3.79e-06

WASF3, CD24, WIF1, AKT1, LGALS3, EPHA2, FLT1, SPHK1, CTNND1, ETV1, ALDH1A1, CEACAM1

Death

C = 343;O = 11;E = 1.77;R = 6.23; p = 1.94e-06;adjP = 3.88e-06

RBM20, ATF4, AKT1, PMAIP1, SPHK1, HRK, BCLAF1, CHUK, MAP3K5, BID, CDK5R1

Leukemia, myeloid

C = 279;O = 10;E = 1.44;R = 6.96; p = 2.14e-06;adjP = 3.97e-06

RARA, HUWE1, PMAIP1, PRDM16, DOK1, CUX1, HRK, BID, SPI1, MYB

Neoplasm

C = 298;O = 10;E = 1.53;R = 6.52; p = 3.84e-06;adjP = 6.24e-06

WASF3, CD24, AKT1, LGALS3, EPHA2, FURIN, CUX1, CTNND1, ETV1, CEACAM1

Invasiveness

Nervous system diseases

C = 694;O = 15;E = 3.57;R = 4.20; p = 3.73e-06;adjP = 6.24e-06

ATXN7, USH1G, PC, PEX6, ASPM, BACE1, DUX4, CST3, SOX3, NEFH, CACNA1H, FOXG1, GIGYF2, XK, CDK5R1

Breast

C = 377;O = 11;E = 1.94;R = 5.67; p = 4.79e-06;adjP = 7.33e-06

S100A7, CD24, AKT1, LGALS3, EPHA2, RB1CC1, FXYD3, RHOBTB2, ALDH1A1, HDAC2, MYB

Neoplasms

Brain diseases

C = 411;O = 11;E = 2.12;R = 5.20; p = 1.08e-05;adjP = 1.56e-05

ATXN7, PC, PEX6, BACE1, CST3, NEFH, AQP1, CACNA1H, FOXG1, GIGYF2, CDK5R1

Schizophrenia

C = 360;O = 10;E = 1.85;R = 5.40; p = 1.98e-05;adjP = 2.57e-05

NDEL1, ATF4, AKT1, CACNA1C, MDGA1, PDE4B, FEZ1, NTF3, ADRBK2, ADRA2A

Central nervous system diseases

C = 438;O = 11;E = 2.25;R = 4.88; p = 1.94e-05;adjP = 2.57e-05

ATXN7, PC, PEX6, BACE1, CST3, NEFH, CACNA1H, FOXG1, GIGYF2, XK, CDK5R1

Virus diseases

C = 488;O = 11;E = 2.51;R = 4.38; p = 5.16e-05;adjP = 6.39e-05

CXCL5, PSMB10, KPNA4, TBK1, MICB, ACTA1, PSMD7, TICAM1, HLA-DOA, FOS, PIK3C2A

Carcinoma

C = 522;O = 11;E = 2.69;R = 4.09; p = 9.37e-05;adjP = 0.0001

S100A7, CD24, WIF1, AKT1, LGALS3, EPHA2, SMO, FH, CTNND1, ALDH1A1, CEACAM1

Pathologic processes

C = 561;O = 10;E = 2.89;R = 3.46; p = 0.0007;adjP = 0.0008

MIF, CXCL5, CD24, HTRA1, PRDM16, JAZF1, ITGA2, FLT1, ZMIZ1, LOXL1

Syndrome

C = 654;O = 10;E = 3.37;R = 2.97; p = 0.0022;adjP = 0.0024

WASF3, USH1G, PEX6, WASL, TOP3A, FH, FOXG1, LOXL1, XK, ZMPSTE24

Genetic

C = 808;O = 10;E = 4.16;R = 2.40; p = 0.0095;adjP = 0.0099

MIF, CACNA1C, HTRA1, JAZF1, ITGA2, PDE4B, ZMIZ1, LOXL1, GIGYF2, ADRA2A

Predisposition to

Disease