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Fig. 3 | BMC Medical Genomics

Fig. 3

From: Molecular subtypes of urothelial carcinoma are defined by specific gene regulatory systems

Fig. 3

Promoter binding overlap in UC and BC downregulated genes. a Co-occurrence of FOXA1, RXRA, GATA3 and PPARG binding in promoter regions of the 664 genes downregulated both in the UC TCGA SCCL and the BC TCGA basal-like subtypes. Co-occurrence derived from the Kittler dataset. b Co-occurrence of FOXA1, RXRA, GATA3 and ESR1 binding in promoter region of the 664 genes downregulated both in the UC TCGA SCCL and the BC TCGA basal-like subtypes. Co-occurrence derived from the Kittler dataset. c Co-localization of binding events. ChIP-Seq peaks in the promoters of the 664 genes downregulated in both the bladder SCCL and breast basal-like subtypes, centered on PPARG binding events (left), and ESR1 (right) binding events

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