Fig. 6
From: Molecular subtypes of urothelial carcinoma are defined by specific gene regulatory systems
A HOXA/HOXB switch in urothelial carcinomas. a Expression of HOXA and HOXB genes. Cases arranged according to HOX-switch score. The HOXA2-A6/HOXB2-B8 expressing group consists mainly of Urobasal A tumors and is enriched for grade G1 tumors. Anterior HOXA b and HOXB c gene clusters show frequent binding sites for RXRA, PPARG, FOXA1, GATA3 and for RARA. d The expression of HOXA2 binding genes across the Lund dataset. Bar above heat map indicates HOX-switch score (red, high score; green, low score). e The expression of HOXA2 binding genes across the Chungbuk cohort. Bar above heat map indicates HOX-switch score (red, high score; green, low score)