Table 1 Summary of the genes analysed in this study
Gene acronym | Full gene name | Known association of mutations with human audiological condition | Reference |
|---|---|---|---|
CDH23 | Cadherin-23 | Non-syndromic deafness, early-onset deafness | |
ESPNL | Espin-like | None reported; protein present in hair bundles (rat and chick) | [13] |
FSCN2 | Fascin-2 | None reported; Fscn2 mutation associated with early onset ≤ 16 kHz hearing loss in C57BL/6 J mice (ahl8); protein present in hair bundles (rat, chick, zebrafish) | |
HCN2 | hyperpolarization activated cyclic nucleotide-gated potassium channel 2 | None reported; expressed in cochlear hair cells (mouse, rat) | |
LCP1 | Plastin-2/L-plastin | None reported; protein present in hair bundles (chick) | [13] |
PDCH15 | protocadherin-15 | Non-syndromic deafness, Usher Syndrome type 1 F | |
XIRP2 | xin actin-binding repeat containing 2 | None reported; protein present in hair bundles (rat and chick) | [13] |
ACAA2 | acetyl-CoA acyltransferase 2 | None reported; ACAA2, c18orf32, CTIF, DYM, MYO5B and SMAD7 are human orthologues of six genes in the ahl9 QTL on mouse chromosome 18 that is associated with low frequency hearing loss in BXD recombinant inbred mice by 2–3 months of age. | [15] |
c18orf32 | chromosome 18 open reading frame 32 | ||
CTIF | CBP80/20-dependent translation initiation factor | ||
DYM | dymeclin | ||
MYO5B | myosin VB | ||
SMAD7 | SMAD family member 7 |