10 most significant SNPs associated with high frequency hearing overall (max n = 4970) | ||||||||
---|---|---|---|---|---|---|---|---|
SNP | Chromosome | Base Position | Gene | Effect Size (dB) | p-value | LD Block | Minor allele | MAF |
rs12959910 | 18 | 46337861 | CTIF | 0.61 | 0.00079 | 19 | G | 0.11 |
rs8085434 | 18 | 46200968 | CTIF | 0.84 | 0.0024 | 8 | C | 0.05 |
rs8091955 | 18 | 46358907 | CTIF | 0.34 | 0.0036 | 22 | G | 0.45 |
rs1994559 | 18 | 46332358 | CTIF | 0.43 | 0.0043 | 19 | A | 0.17 |
rs1319946 | 18 | 46359024 | CTIF | 0.31 | 0.0067 | 22 | C | 0.49 |
rs1877192 | 2 | 167863420 | XIRP2 | 0.43 | 0.014 | 3 | C | 0.12 |
rs10825335 | 10 | 56234349 | PCDH15 | 0.41 | 0.022 | 18 | A | 0.11 |
rs1317625 | 18 | 46380182 | CTIF | 0.3 | 0.026 | 25 | A | 0.22 |
rs7233521 | 18 | 46219733 | CTIF | 0.43 | 0.031 | 11 | A | 0.09 |
rs1316826 | 18 | 46348156 | CTIF | 0.26 | 0.032 | 18 | C | 0.31 |
10 most significant SNPs associated with high frequency hearing in males (max n = 2445) | ||||||||
SNP | Chromosome | Base Position | Gene | Effect Size (dB) | p-value | LD Block | Minor allele | MAF |
rs2337069 | 18 | 46120940 | CTIF | 0.58 | 0.0041 | 3 | T | 0.22 |
rs16951446 | 18 | 47599093 | MYO5B | −1.06 | 0.0047 | 8 | G | 0.05 |
rs16951488 | 18 | 47610821 | MYO5B | −1.06 | 0.0047 | 8 | G | 0.05 |
rs8085434 | 18 | 46200968 | CTIF | 1.04 | 0.0093 | 8 | C | 0.05 |
rs10823837 | 10 | 73498910 | CDH23 | 0.44 | 0.0094 | 1 | C | 0.43 |
rs1877192 | 2 | 167863420 | XIRP2 | 0.65 | 0.011 | 3 | C | 0.12 |
rs11662494 | 18 | 46241017 | CTIF | −0.57 | 0.012 | 13 | T | 0.15 |
rs10825335 | 10 | 56234349 | PCDH15 | 0.67 | 0.012 | 18 | A | 0.11 |
rs869000 | 2 | 167862974 | XIRP2 | 0.74 | 0.019 | 3 | C | 0.07 |
rs4939612 | 18 | 47541612 | MYO5B | 0.52 | 0.022 | 7 | T | 0.16 |
10 most significant SNPs associated with high frequency hearing in females (max n = 2525) | ||||||||
SNP | Chromosome | Base Position | Gene | Effect Size (dB) | p-value | LD Block | Minor allele | MAF |
rs4592338 | 10 | 56098424 | PCDH15 | 1.21 | 0.0027 | 16 | A | 0.04 |
rs978674 | 10 | 56119975 | PCDH15 | 1.17 | 0.0032 | 16 | A | 0.04 |
rs7321994 | 13 | 46742539 | LCP1 | −0.53 | 0.0055 | 2 | A | 0.20 |
rs1787534 | 18 | 47445407 | MYO5B | 0.75 | 0.0055 | 1 | T | 0.09 |
rs873816 | 18 | 46101074 | CTIF | −0.59 | 0.0079 | 2 | C | 0.15 |
rs9567638 | 13 | 46754734 | LCP1 | −1.43 | 0.0084 | 3 | C | 0.02 |
rs8087713 | 18 | 46677185 | DYM | 0.54 | 0.011 | 2 | G | 0.17 |
rs10775489 | 18 | 46667299 | DYM | 0.54 | 0.011 | 2 | A | 0.17 |
rs12959910 | 18 | 46337861 | CTIF | 0.64 | 0.012 | 19 | G | 0.10 |
rs2296119 | 13 | 46729259 | LCP1 | −0.49 | 0.015 | 2 | T | 0.17 |
10 most significant SNPs associated with low frequency hearing overall (max n = 4970) | ||||||||
SNP | Chromosome | Base Position | Gene | Effect Size (dB) | p-value | LD Block | Minor allele | MAF |
rs10492452 | 13 | 46721562 | LCP1 | 0.45 | 0.00056 | 1 | A | 0.20 |
rs16951446 | 18 | 47599093 | MYO5B | −0.73 | 0.0017 | 1 | G | 0.05 |
rs16951488 | 18 | 47610821 | MYO5B | −0.73 | 0.0017 | 1 | G | 0.05 |
rs16913796 | 10 | 55659824 | PCDH15 | −0.59 | 0.003 | 3 | T | 0.08 |
rs6561296 | 13 | 46702401 | LCP1 | 0.38 | 0.0033 | 1 | C | 0.21 |
rs9316187 | 13 | 46713702 | LCP1 | 0.33 | 0.0079 | 1 | A | 0.24 |
rs6432974 | 2 | 167982976 | XIRP2 | 0.39 | 0.0097 | 5 | T | 0.14 |
rs1937389 | 10 | 56319852 | PCDH15 | 0.37 | 0.01 | 24 | G | 0.16 |
rs11003924 | 10 | 55662156 | PCDH15 | −0.44 | 0.01 | 4 | T | 0.11 |
rs11003925 | 10 | 55662226 | PCDH15 | −0.44 | 0.01 | 4 | T | 0.11 |
10 most significant SNPs associated with low frequency hearing in males (max n = 2445) | ||||||||
SNP | Chromosome | Base Position | Gene | Effect Size (dB) | p-value | LD Block | Minor allele | MAF |
rs1877192 | 2 | 167863420 | XIRP2 | 0.69 | 0.0017 | 3 | C | 0.12 |
rs12571150 | 10 | 56546055 | PCDH15 | −0.51 | 0.0022 | 29 | T | 0.25 |
rs16951446 | 18 | 47599093 | MYO5B | −0.89 | 0.0062 | 1 | G | 0.05 |
rs16951488 | 18 | 47610821 | MYO5B | −0.89 | 0.0062 | 1 | G | 0.05 |
rs1912985 | 10 | 56538759 | PCDH15 | 0.53 | 0.0068 | 28 | T | 0.16 |
rs10492452 | 13 | 46721562 | LCP1 | 0.48 | 0.008 | 1 | A | 0.20 |
rs1317355 | 18 | 46379626 | CTIF | 0.45 | 0.0086 | 24 | T | 0.23 |
rs877885 | 18 | 46241163 | CTIF | 0.42 | 0.0097 | 13 | A | 0.26 |
rs11662494 | 18 | 46241017 | CTIF | −0.51 | 0.0098 | 13 | T | 0.15 |
rs937023 | 18 | 46383785 | CTIF | 0.41 | 0.011 | 25 | C | 0.28 |
10 most significant SNPs associated with low frequency hearing in females (max n = 2525) | ||||||||
SNP | Chromosome | Base Position | Gene | Effect Size (dB) | p-value | LD Block | Minor allele | MAF |
rs7233521 | 18 | 46219733 | CTIF | 0.98 | 0.00047 | 11 | A | 0.09 |
rs9567638 | 13 | 46754734 | LCP1 | −1.76 | 0.0011 | 3 | C | 0.02 |
rs7321994 | 13 | 46742539 | LCP1 | −0.55 | 0.0039 | 2 | A | 0.20 |
rs11003876 | 10 | 55594049 | PCDH15 | 0.45 | 0.004 | 1 | C | 0.43 |
rs11003889 | 10 | 55623229 | PCDH15 | 0.49 | 0.0057 | 1 | C | 0.27 |
rs1937389 | 10 | 56319852 | PCDH15 | 0.58 | 0.006 | 24 | G | 0.16 |
rs2296119 | 13 | 46729259 | LCP1 | −0.55 | 0.0062 | 2 | T | 0.17 |
rs4478893 | 10 | 55635024 | PCDH15 | 0.43 | 0.0087 | 2 | G | 0.34 |
rs1900425 | 10 | 55638740 | PCDH15 | 0.42 | 0.0093 | 3 | A | 0.34 |
rs8087713 | 18 | 46677185 | DYM | 0.54 | 0.01 | 2 | G | 0.17 |