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# Table 5 Effect sizes of SNPs in *CTIF* or *LCP1* for averaged high or low frequency hearing compared between ALSPAC and G-EAR

CTIF: 10 most significant SNPs in high frequency tests overall
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SNP | Minor Allele | Major allele | ALSPAC MAF | ALSPAC Effect Size (dB) |
ALSPAC p-value
| G-EAR Effect Size (rank normal) |
G-EAR p-value
| LD Block |

rs12959910 | G | A | 0.11 | 0.61 | 0.0008 | 0.096 | 0.11 | 19 |

rs8085434 | C | T | 0.05 | 0.84 | 0.002 | 0.081 | 0.27 | 8 |

rs8091955 | G | A | 0.45 | 0.34 | 0.004 | 0.045 | 0.22 | 22 |

rs1994559 | A | G | 0.17 | 0.43 | 0.004 | 0.059 | 0.23 | 19 |

rs1319946 | C | T | 0.49 | 0.31 | 0.007 | 0.040 | 0.24 | 22 |

rs1317625 | A | G | 0.22 | 0.30 | 0.026 | −0.021 | 0.59 | 25 |

rs7233521 | A | G | 0.09 | 0.43 | 0.031 | 0.069 | 0.35 | 11 |

rs1316826 | C | T | 0.31 | 0.26 | 0.032 | 0.059 | 0.17 | 21 |

rs4583322 | A | G | 0.35 | 0.25 | 0.032 | 0.008 | 0.82 | 19 |

rs937021 | G | A | 0.44 | 0.23 | 0.039 | −0.043 | 0.21 | 25 |

CTIF: 10 most significant SNPs in high frequency tests in males
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SNP | Minor Allele | Major allele | ALSPAC MAF | ALSPAC Effect Size (dB) |
ALSPAC p-value
| G-EAR Effect Size (rank normal) |
G-EAR p-value
| LD Block |

rs2337069 | T | C | 0.22 | 0.58 | 0.004 | 0.010 | 0.26 | 3 |

rs8085434 | C | T | 0.05 | 1.04 | 0.009 | 0.002 | 0.89 | 8 |

rs11662494 | T | C | 0.15 | −0.57 | 0.012 | 0.001 | 0.91 | 13 |

rs937021 | G | A | 0.45 | 0.37 | 0.026 | 0.003 | 0.74 | 25 |

rs12959910 | G | A | 0.11 | 0.57 | 0.030 | 0.021 | 0.10 | 19 |

rs7227797 | G | A | 0.31 | 0.38 | 0.033 | 0.014 | 0.07 | 3 |

rs1994559 | A | G | 0.18 | 0.44 | 0.040 | 0.002 | 0.82 | 19 |

rs11082695 | A | G | 0.17 | −0.43 | 0.048 | 0.001 | 0.95 | 13 |

rs8091955 | G | A | 0.46 | 0.32 | 0.058 | 0.014 | 0.08 | 22 |

rs1319946 | C | T | 0.50 | 0.32 | 0.060 | 0.009 | 0.20 | 22 |

CTIF: 10 most significant SNPs in high frequency tests in females
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SNP | Minor Allele | Major allele | ALSPAC MAF | ALSPAC Effect Size (dB) |
ALSPAC p-value
| G-EAR Effect Size (rank normal) |
G-EAR p-value
| LD Block |

rs873816 | C | T | 0.15 | −0.59 | 0.008 | −0.003 | 0.69 | 2 |

rs12959910 | G | A | 0.10 | 0.64 | 0.012 | −0.007 | 0.55 | 19 |

rs8091955 | G | A | 0.45 | 0.33 | 0.036 | 0.001 | 0.86 | 22 |

rs4939781 | G | A | 0.21 | −0.40 | 0.040 | −0.009 | 0.20 | 2 |

rs11082698 | G | A | 0.46 | 0.32 | 0.043 | −0.008 | 0.18 | 14 |

rs1317625 | A | G | 0.21 | 0.38 | 0.047 | −0.001 | 0.83 | 25 |

rs4939804 | A | G | 0.23 | 0.36 | 0.053 | −0.004 | 0.60 | 14 |

rs11662760 | A | G | 0.09 | −0.53 | 0.056 | −0.006 | 0.58 | 1 |

rs7233521 | A | G | 0.09 | 0.54 | 0.058 | −0.028 | 0.04 | 11 |

rs1319946 | C | T | 0.49 | 0.30 | 0.062 | −0.001 | 0.90 | 22 |

LCP1: 10 most significant SNPs in low frequency tests overall
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SNP | Minor Allele | Major allele | ALSPAC MAF | ALSPAC Effect Size (dB) |
ALSPAC p-value
| G-EAR Effect Size (rank normal) |
G-EAR p-value
| LD Block |

rs10492452 | A | C | 0.20 | 0.45 | 0.0006 | −0.009 | 0.86 | 1 |

rs6561296 | C | T | 0.21 | 0.38 | 0.003 | −0.013 | 0.79 | 1 |

rs9316187 | A | G | 0.24 | 0.33 | 0.008 | 0.007 | 0.87 | 1 |

rs1409437 | G | A | 0.44 | −0.23 | 0.029 | −0.066 | 0.08 | 1 |

rs2146880 | A | C | 0.45 | 0.23 | 0.030 | 0.025 | 0.52 | 1 |

rs1886040 | C | T | 0.49 | 0.22 | 0.039 | 0.028 | 0.47 | 1 |

rs2093707 | A | C | 0.49 | 0.21 | 0.046 | 0.034 | 0.37 | 1 |

rs7321994 | A | G | 0.20 | −0.24 | 0.067 | −0.047 | 0.25 | 2 |

rs2209093 | C | T | 0.17 | −0.25 | 0.074 | −0.071 | 0.09 | 2 |

rs2296119 | T | C | 0.17 | −0.25 | 0.076 | −0.032 | 0.46 | 2 |

LCP1: 10 most significant SNPs in low frequency tests in males
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SNP | Minor Allele | Major allele | ALSPAC MAF | ALSPAC Effect Size (dB) |
ALSPAC p-value
| G-EAR Effect Size (rank normal) |
G-EAR p-value
| LD Block |

rs10492452 | A | C | 0.20 | 0.48 | 0.008 | −0.004 | 0.67 | 1 |

rs6561296 | C | T | 0.21 | 0.40 | 0.026 | −0.006 | 0.48 | 1 |

rs9316187 | A | G | 0.24 | 0.37 | 0.031 | −0.004 | 0.63 | 1 |

rs1409437 | G | A | 0.44 | −0.30 | 0.039 | 0.003 | 0.60 | 1 |

rs2146880 | A | C | 0.45 | 0.26 | 0.072 | −0.001 | 0.89 | 1 |

rs1886040 | C | T | 0.49 | 0.26 | 0.075 | −0.003 | 0.56 | 1 |

rs2093707 | A | C | 0.49 | 0.25 | 0.081 | −0.003 | 0.66 | 1 |

rs17601960 | C | T | 0.08 | −0.36 | 0.168 | 0.043 | 0.01 | 3 |

rs9567638 | C | T | 0.02 | 0.59 | 0.246 | 0.024 | 0.48 | 3 |

rs10492449 | G | T | 0.33 | 0.14 | 0.373 | −0.006 | 0.33 | 3 |

LCP1: 10 most significant SNPs in low frequency tests in females
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SNP | Minor Allele | Major allele | ALSPAC MAF | ALSPAC Effect Size (dB) |
ALSPAC p-value
| G-EAR Effect Size (rank normal) |
G-EAR p-value
| LD Block |

rs9567638 | C | T | 0.02 | −1.76 | 0.0011 | 0.021 | 0.53 | 3 |

rs7321994 | A | G | 0.20 | −0.55 | 0.004 | 0.006 | 0.19 | 2 |

rs2296119 | T | C | 0.17 | −0.55 | 0.006 | 0.005 | 0.35 | 2 |

rs2209093 | C | T | 0.17 | −0.50 | 0.012 | 0.005 | 0.27 | 2 |

rs10492452 | A | C | 0.21 | 0.43 | 0.026 | 0.003 | 0.64 | 1 |

rs2209092 | G | A | 0.22 | −0.37 | 0.042 | 0.006 | 0.17 | 2 |

rs6561296 | C | T | 0.22 | 0.36 | 0.056 | 0.004 | 0.55 | 1 |

rs9316187 | A | G | 0.24 | 0.29 | 0.110 | 0.007 | 0.25 | 1 |

rs2146880 | A | C | 0.45 | 0.20 | 0.202 | 0.000 | 0.97 | 1 |

rs1886040 | C | T | 0.49 | 0.18 | 0.247 | 0.003 | 0.55 | 1 |