Table 5 Effect sizes of SNPs in CTIF or LCP1 for averaged high or low frequency hearing compared between ALSPAC and G-EAR

rs12959910

G

A

0.11

0.61

0.0008

0.096

0.11

19

rs8085434

C

T

0.05

0.84

0.002

0.081

0.27

8

rs8091955

G

A

0.45

0.34

0.004

0.045

0.22

22

rs1994559

A

G

0.17

0.43

0.004

0.059

0.23

19

rs1319946

C

T

0.49

0.31

0.007

0.040

0.24

22

rs1317625

A

G

0.22

0.30

0.026

−0.021

0.59

25

rs7233521

A

G

0.09

0.43

0.031

0.069

0.35

11

rs1316826

C

T

0.31

0.26

0.032

0.059

0.17

21

rs4583322

A

G

0.35

0.25

0.032

0.008

0.82

19

rs937021

G

A

0.44

0.23

0.039

−0.043

0.21

25

SNP

Minor Allele

Major allele

ALSPAC MAF

ALSPAC Effect Size (dB)

ALSPAC p-value

G-EAR Effect Size (rank normal)

G-EAR p-value

LD Block

rs2337069

T

C

0.22

0.58

0.004

0.010

0.26

3

rs8085434

C

T

0.05

1.04

0.009

0.002

0.89

8

rs11662494

T

C

0.15

−0.57

0.012

0.001

0.91

13

rs937021

G

A

0.45

0.37

0.026

0.003

0.74

25

rs12959910

G

A

0.11

0.57

0.030

0.021

0.10

19

rs7227797

G

A

0.31

0.38

0.033

0.014

0.07

3

rs1994559

A

G

0.18

0.44

0.040

0.002

0.82

19

rs11082695

A

G

0.17

−0.43

0.048

0.001

0.95

13

rs8091955

G

A

0.46

0.32

0.058

0.014

0.08

22

rs1319946

C

T

0.50

0.32

0.060

0.009

0.20

22

SNP

Minor Allele

Major allele

ALSPAC MAF

ALSPAC Effect Size (dB)

ALSPAC p-value

G-EAR Effect Size (rank normal)

G-EAR p-value

LD Block

rs873816

C

T

0.15

−0.59

0.008

−0.003

0.69

2

rs12959910

G

A

0.10

0.64

0.012

−0.007

0.55

19

rs8091955

G

A

0.45

0.33

0.036

0.001

0.86

22

rs4939781

G

A

0.21

−0.40

0.040

−0.009

0.20

2

rs11082698

G

A

0.46

0.32

0.043

−0.008

0.18

14

rs1317625

A

G

0.21

0.38

0.047

−0.001

0.83

25

rs4939804

A

G

0.23

0.36

0.053

−0.004

0.60

14

rs11662760

A

G

0.09

−0.53

0.056

−0.006

0.58

1

rs7233521

A

G

0.09

0.54

0.058

−0.028

0.04

11

rs1319946

C

T

0.49

0.30

0.062

−0.001

0.90

22

SNP

Minor Allele

Major allele

ALSPAC MAF

ALSPAC Effect Size (dB)

ALSPAC p-value

G-EAR Effect Size (rank normal)

G-EAR p-value

LD Block

rs10492452

A

C

0.20

0.45

0.0006

−0.009

0.86

1

rs6561296

C

T

0.21

0.38

0.003

−0.013

0.79

1

rs9316187

A

G

0.24

0.33

0.008

0.007

0.87

1

rs1409437

G

A

0.44

−0.23

0.029

−0.066

0.08

1

rs2146880

A

C

0.45

0.23

0.030

0.025

0.52

1

rs1886040

C

T

0.49

0.22

0.039

0.028

0.47

1

rs2093707

A

C

0.49

0.21

0.046

0.034

0.37

1

rs7321994

A

G

0.20

−0.24

0.067

−0.047

0.25

2

rs2209093

C

T

0.17

−0.25

0.074

−0.071

0.09

2

rs2296119

T

C

0.17

−0.25

0.076

−0.032

0.46

2

SNP

Minor Allele

Major allele

ALSPAC MAF

ALSPAC Effect Size (dB)

ALSPAC p-value

G-EAR Effect Size (rank normal)

G-EAR p-value

LD Block

rs10492452

A

C

0.20

0.48

0.008

−0.004

0.67

1

rs6561296

C

T

0.21

0.40

0.026

−0.006

0.48

1

rs9316187

A

G

0.24

0.37

0.031

−0.004

0.63

1

rs1409437

G

A

0.44

−0.30

0.039

0.003

0.60

1

rs2146880

A

C

0.45

0.26

0.072

−0.001

0.89

1

rs1886040

C

T

0.49

0.26

0.075

−0.003

0.56

1

rs2093707

A

C

0.49

0.25

0.081

−0.003

0.66

1

rs17601960

C

T

0.08

−0.36

0.168

0.043

0.01

3

rs9567638

C

T

0.02

0.59

0.246

0.024

0.48

3

rs10492449

G

T

0.33

0.14

0.373

−0.006

0.33

3

SNP

Minor Allele

Major allele

ALSPAC MAF

ALSPAC Effect Size (dB)

ALSPAC p-value

G-EAR Effect Size (rank normal)

G-EAR p-value

LD Block

rs9567638

C

T

0.02

−1.76

0.0011

0.021

0.53

3

rs7321994

A

G

0.20

−0.55

0.004

0.006

0.19

2

rs2296119

T

C

0.17

−0.55

0.006

0.005

0.35

2

rs2209093

C

T

0.17

−0.50

0.012

0.005

0.27

2

rs10492452

A

C

0.21

0.43

0.026

0.003

0.64

1

rs2209092

G

A

0.22

−0.37

0.042

0.006

0.17

2

rs6561296

C

T

0.22

0.36

0.056

0.004

0.55

1

rs9316187

A

G

0.24

0.29

0.110

0.007

0.25

1

rs2146880

A

C

0.45

0.20

0.202

0.000

0.97

1

rs1886040

C

T

0.49

0.18

0.247

0.003

0.55

1