rs12959910
|
G
|
A
|
0.11
|
0.61
|
0.0008
|
0.096
|
0.11
|
19
|
rs8085434
|
C
|
T
|
0.05
|
0.84
|
0.002
|
0.081
|
0.27
|
8
|
rs8091955
|
G
|
A
|
0.45
|
0.34
|
0.004
|
0.045
|
0.22
|
22
|
rs1994559
|
A
|
G
|
0.17
|
0.43
|
0.004
|
0.059
|
0.23
|
19
|
rs1319946
|
C
|
T
|
0.49
|
0.31
|
0.007
|
0.040
|
0.24
|
22
|
rs1317625
|
A
|
G
|
0.22
|
0.30
|
0.026
|
−0.021
|
0.59
|
25
|
rs7233521
|
A
|
G
|
0.09
|
0.43
|
0.031
|
0.069
|
0.35
|
11
|
rs1316826
|
C
|
T
|
0.31
|
0.26
|
0.032
|
0.059
|
0.17
|
21
|
rs4583322
|
A
|
G
|
0.35
|
0.25
|
0.032
|
0.008
|
0.82
|
19
|
rs937021
|
G
|
A
|
0.44
|
0.23
|
0.039
|
−0.043
|
0.21
|
25
|
CTIF: 10 most significant SNPs in high frequency tests in males
|
SNP
|
Minor Allele
|
Major allele
|
ALSPAC MAF
|
ALSPAC Effect Size (dB)
|
ALSPAC p-value
|
G-EAR Effect Size (rank normal)
|
G-EAR p-value
|
LD Block
|
rs2337069
|
T
|
C
|
0.22
|
0.58
|
0.004
|
0.010
|
0.26
|
3
|
rs8085434
|
C
|
T
|
0.05
|
1.04
|
0.009
|
0.002
|
0.89
|
8
|
rs11662494
|
T
|
C
|
0.15
|
−0.57
|
0.012
|
0.001
|
0.91
|
13
|
rs937021
|
G
|
A
|
0.45
|
0.37
|
0.026
|
0.003
|
0.74
|
25
|
rs12959910
|
G
|
A
|
0.11
|
0.57
|
0.030
|
0.021
|
0.10
|
19
|
rs7227797
|
G
|
A
|
0.31
|
0.38
|
0.033
|
0.014
|
0.07
|
3
|
rs1994559
|
A
|
G
|
0.18
|
0.44
|
0.040
|
0.002
|
0.82
|
19
|
rs11082695
|
A
|
G
|
0.17
|
−0.43
|
0.048
|
0.001
|
0.95
|
13
|
rs8091955
|
G
|
A
|
0.46
|
0.32
|
0.058
|
0.014
|
0.08
|
22
|
rs1319946
|
C
|
T
|
0.50
|
0.32
|
0.060
|
0.009
|
0.20
|
22
|
CTIF: 10 most significant SNPs in high frequency tests in females
|
SNP
|
Minor Allele
|
Major allele
|
ALSPAC MAF
|
ALSPAC Effect Size (dB)
|
ALSPAC p-value
|
G-EAR Effect Size (rank normal)
|
G-EAR p-value
|
LD Block
|
rs873816
|
C
|
T
|
0.15
|
−0.59
|
0.008
|
−0.003
|
0.69
|
2
|
rs12959910
|
G
|
A
|
0.10
|
0.64
|
0.012
|
−0.007
|
0.55
|
19
|
rs8091955
|
G
|
A
|
0.45
|
0.33
|
0.036
|
0.001
|
0.86
|
22
|
rs4939781
|
G
|
A
|
0.21
|
−0.40
|
0.040
|
−0.009
|
0.20
|
2
|
rs11082698
|
G
|
A
|
0.46
|
0.32
|
0.043
|
−0.008
|
0.18
|
14
|
rs1317625
|
A
|
G
|
0.21
|
0.38
|
0.047
|
−0.001
|
0.83
|
25
|
rs4939804
|
A
|
G
|
0.23
|
0.36
|
0.053
|
−0.004
|
0.60
|
14
|
rs11662760
|
A
|
G
|
0.09
|
−0.53
|
0.056
|
−0.006
|
0.58
|
1
|
rs7233521
|
A
|
G
|
0.09
|
0.54
|
0.058
|
−0.028
|
0.04
|
11
|
rs1319946
|
C
|
T
|
0.49
|
0.30
|
0.062
|
−0.001
|
0.90
|
22
|
LCP1: 10 most significant SNPs in low frequency tests overall
|
SNP
|
Minor Allele
|
Major allele
|
ALSPAC MAF
|
ALSPAC Effect Size (dB)
|
ALSPAC p-value
|
G-EAR Effect Size (rank normal)
|
G-EAR p-value
|
LD Block
|
rs10492452
|
A
|
C
|
0.20
|
0.45
|
0.0006
|
−0.009
|
0.86
|
1
|
rs6561296
|
C
|
T
|
0.21
|
0.38
|
0.003
|
−0.013
|
0.79
|
1
|
rs9316187
|
A
|
G
|
0.24
|
0.33
|
0.008
|
0.007
|
0.87
|
1
|
rs1409437
|
G
|
A
|
0.44
|
−0.23
|
0.029
|
−0.066
|
0.08
|
1
|
rs2146880
|
A
|
C
|
0.45
|
0.23
|
0.030
|
0.025
|
0.52
|
1
|
rs1886040
|
C
|
T
|
0.49
|
0.22
|
0.039
|
0.028
|
0.47
|
1
|
rs2093707
|
A
|
C
|
0.49
|
0.21
|
0.046
|
0.034
|
0.37
|
1
|
rs7321994
|
A
|
G
|
0.20
|
−0.24
|
0.067
|
−0.047
|
0.25
|
2
|
rs2209093
|
C
|
T
|
0.17
|
−0.25
|
0.074
|
−0.071
|
0.09
|
2
|
rs2296119
|
T
|
C
|
0.17
|
−0.25
|
0.076
|
−0.032
|
0.46
|
2
|
LCP1: 10 most significant SNPs in low frequency tests in males
|
SNP
|
Minor Allele
|
Major allele
|
ALSPAC MAF
|
ALSPAC Effect Size (dB)
|
ALSPAC p-value
|
G-EAR Effect Size (rank normal)
|
G-EAR p-value
|
LD Block
|
rs10492452
|
A
|
C
|
0.20
|
0.48
|
0.008
|
−0.004
|
0.67
|
1
|
rs6561296
|
C
|
T
|
0.21
|
0.40
|
0.026
|
−0.006
|
0.48
|
1
|
rs9316187
|
A
|
G
|
0.24
|
0.37
|
0.031
|
−0.004
|
0.63
|
1
|
rs1409437
|
G
|
A
|
0.44
|
−0.30
|
0.039
|
0.003
|
0.60
|
1
|
rs2146880
|
A
|
C
|
0.45
|
0.26
|
0.072
|
−0.001
|
0.89
|
1
|
rs1886040
|
C
|
T
|
0.49
|
0.26
|
0.075
|
−0.003
|
0.56
|
1
|
rs2093707
|
A
|
C
|
0.49
|
0.25
|
0.081
|
−0.003
|
0.66
|
1
|
rs17601960
|
C
|
T
|
0.08
|
−0.36
|
0.168
|
0.043
|
0.01
|
3
|
rs9567638
|
C
|
T
|
0.02
|
0.59
|
0.246
|
0.024
|
0.48
|
3
|
rs10492449
|
G
|
T
|
0.33
|
0.14
|
0.373
|
−0.006
|
0.33
|
3
|
LCP1: 10 most significant SNPs in low frequency tests in females
|
SNP
|
Minor Allele
|
Major allele
|
ALSPAC MAF
|
ALSPAC Effect Size (dB)
|
ALSPAC p-value
|
G-EAR Effect Size (rank normal)
|
G-EAR p-value
|
LD Block
|
rs9567638
|
C
|
T
|
0.02
|
−1.76
|
0.0011
|
0.021
|
0.53
|
3
|
rs7321994
|
A
|
G
|
0.20
|
−0.55
|
0.004
|
0.006
|
0.19
|
2
|
rs2296119
|
T
|
C
|
0.17
|
−0.55
|
0.006
|
0.005
|
0.35
|
2
|
rs2209093
|
C
|
T
|
0.17
|
−0.50
|
0.012
|
0.005
|
0.27
|
2
|
rs10492452
|
A
|
C
|
0.21
|
0.43
|
0.026
|
0.003
|
0.64
|
1
|
rs2209092
|
G
|
A
|
0.22
|
−0.37
|
0.042
|
0.006
|
0.17
|
2
|
rs6561296
|
C
|
T
|
0.22
|
0.36
|
0.056
|
0.004
|
0.55
|
1
|
rs9316187
|
A
|
G
|
0.24
|
0.29
|
0.110
|
0.007
|
0.25
|
1
|
rs2146880
|
A
|
C
|
0.45
|
0.20
|
0.202
|
0.000
|
0.97
|
1
|
rs1886040
|
C
|
T
|
0.49
|
0.18
|
0.247
|
0.003
|
0.55
|
1
|