Table 3 Genes and genomes pathway analysis of miR-146a target genes
From: Genome–wide microRNA expression profiling in placentas from pregnant women exposed to BPA
Pathway | Gene Symbol | Gene Name |
|---|---|---|
Apoptosis | IRAK1 | interleukin-1 receptor-associated kinase 1, |
Cancer | APPL1 | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; |
SLC22A3 | solute carrier family 22 (extraneuronal monoamine transporter), member 3; | |
ERBB4 | v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian); | |
NOTCH1 | notch 1; | |
SMAD4 | SMAD family member 4; | |
CSF1R | colony stimulating factor 1 receptor; | |
DOT1L | DOT1-like, histone H3 methyltransferase (S. cerevisiae); | |
PTGFRN | prostaglandin F2 receptor negative regulator; | |
IGF2BP1 | insulin-like growth factor 2 mRNA binding protein 1; | |
BCL11A | B-cell CLL/lymphoma 11A (zinc finger protein); | |
RAD1 | RAD1 homolog (S. pombe); | |
HIC2 | hypermethylated in cancer 2; | |
MLL2 | myeloid/lymphoid or mixed-lineage leukemia 2; | |
EDNRB | endothelin receptor type B; | |
NOVA1 | neuro-oncological ventral antigen 1; | |
ABL2 | v-abl Abelson murine leukemia viral oncogene homolog 2 | |
Mapk pathway | TRAF6 | TNF receptor-associated factor 6 |
Cell differentation | NOTCH1 | notch 1; |
SRP14 | signal recognition particle 14 kDa (homologous Alu RNA binding protein); | |
PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3; | |
GDNF | glial cell derived neurotrophic factor; | |
SMAD4 | SMAD family member 4; | |
SEMA3G | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G; | |
MED1 | mediator complex subunit 1; | |
LIPA | lipase A, lysosomal acid, cholesterol esterase; | |
ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila); | |
Metabolic pathway | SLC22A3 | solute carrier family 22 (extraneuronal monoamine transporter), member 3; |
PGP | phosphoglycolate phosphatase; | |
LIPA | lipase A, lysosomal acid, cholesterol esterase; | |
DLST | dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex); | |
DOT1L | DOT1-like, histone H3 methyltransferase (S. cerevisiae); | |
BCL11A | B-cell CLL/lymphoma 11A (zinc finger protein; | |
DGKG | diacylglycerol kinase, gamma 90 kDa; | |
Neural disease | IRAK1 | interleukin-1 receptor-associated kinase 1; |
MYT1 | myelin transcription factor 1; | |
ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila); | |
LRRTM2 | leucine rich repeat transmembrane neuronal 2; | |
GRID1 | glutamate receptor, ionotropic, delta 1; | |
SORT1 | sortilin 1; | |
BCL11A | B-cell CLL/lymphoma 11A (zinc finger protein); | |
SYT1 | synaptotagmin I; | |
NPAS4 | neuronal PAS domain protein 4; | |
MLL2 | myeloid/lymphoid or mixed-lineage leukemia 2; | |
DNAL1 | dynein, axonemal, light chain 1; | |
EDNRB | endothelin receptor type B; | |
Binding protein | NOVA1 | neuro-oncological ventral antigen 1; |
HNRNPD | heterogeneous nuclear ribonucleoprotein D | |
Signal trasduction | ABL2 | v-abl Abelson murine leukemia viral oncogene homolog 2; |
NUMB | numb homolog (Drosophila); | |
CNTFR | ciliary neurotrophic factor receptor; | |
SRP14 | signal recognition particle 14 kDa (homologous Alu RNA binding protein); | |
GDNF | glial cell derived neurotrophic factor; | |
SMAD4 | SMAD family member 4; | |
KCTD15 | potassium channel tetramerisation domain containing 15; | |
NF2 | neurofibromin 2 (merlin); | |
KLF4 | Kruppel-like factor 4 (gut); | |
SCN3B | sodium channel, voltage-gated, type III, beta; | |
NLGN1 | neuroligin 1; | |
RIMS2 | regulating synaptic membrane exocytosis 2; | |
Cardiovascular disease | ABL2 | v-abl Abelson murine leukemia viral oncogene homolog 2; |
EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2; | |
EDNRB | endothelin receptor type B; | |
Ubiquitin pathway | DCAF12 | DDB1 and CUL4 associated factor 12; |
FBXW2 | F-box and WD repeat domain containing 2; | |
WWP2 | WW domain containing E3 ubiquitin protein ligase 2; | |
DTL | denticleless homolog (Drosophila); | |
Trasport protein | SLC10A3 | solute carrier family 10 (sodium/bile acid cotransporter family), member 3; |
ERBB4 | v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian); | |
EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2; | |
SH3GL2 | SH3-domain GRB2-like 2; | |
SLCO3A1 | solute carrier organic anion transporter family, member 3A1; | |
GOSR1 | golgi SNAP receptor complex member 1; | |
SLC39A1 | solute carrier family 39 (zinc transporter), member 1; | |
SORT1 | sortilin 1; | |
BTG2 | BTG family, member 2; | |
Enzyme | ERBB4 | v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian); |
ADARB1 | adenosine deaminase, RNA-specific, B1; | |
USP3 | ubiquitin specific peptidase 3; | |
KDM2B | lysine (K)-specific demethylase 2B; | |
SIAH2 | seven in absentia homolog 2 (Drosophila); | |
CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family); | |
LIPA | lipase A, lysosomal acid, cholesterol esterase; | |
CNOT6L | ||
TRDMT1 | CCR4-NOT transcription complex, subunit 6-like; | |
MPPE1 | tRNA aspartic acid methyltransferase 1; | |
DCP1A | DCP1 decapping enzyme homolog A (S. cerevisiae); | |
DLGAP2 | discs, large (Drosophila) homolog-associated protein 2; | |
Kinase protein associated | TRAF6 | TNF receptor-associated factor 6; |
PCDH1 | protocadherin 1; | |
Prion disease | NOTCH1 | notch 1 |
Infection disease | APPL1 | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; |
PGP | phosphoglycolate phosphatase; | |
PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3; | |
SMAD4 | SMAD family member 4; | |
TAF9B | TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31 kDa; | |
CD28 | CD28 molecule; | |
WASF2 | WAS protein family, member 2; | |
SRSF7 | serine/arginine-rich splicing factor 7; | |
Trascriptor factor | MAFF | v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian); |
CSF1R | colony stimulating factor 1 receptor; | |
TAF9B | TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor; | |
EIF5A2 | eukaryotic translation initiation factor 5A2; | |
KLF4 | Kruppel-like factor 4 (gut); | |
SP8 | Sp8 transcription factor; | |
SOX5 | SRY (sex determining region Y)-box 5; | |
Endocrine system | MED1 | mediator complex subunit 1; |
TP53RK | TP53 regulating kinase; | |
Cellular antigen | CD84 | CD84 molecule |
Mirna survelliance | PPP2R3A | protein phosphatase 2, regulatory subunit B’, alpha; |
RIMS2 | regulating synaptic membrane exocytosis 2; |