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Table 3 Genes and genomes pathway analysis of miR-146a target genes

From: Genome–wide microRNA expression profiling in placentas from pregnant women exposed to BPA

Pathway Gene Symbol Gene Name
Apoptosis IRAK1 interleukin-1 receptor-associated kinase 1,
Cancer APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1;
SLC22A3 solute carrier family 22 (extraneuronal monoamine transporter), member 3;
ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian);
NOTCH1 notch 1;
SMAD4 SMAD family member 4;
CSF1R colony stimulating factor 1 receptor;
DOT1L DOT1-like, histone H3 methyltransferase (S. cerevisiae);
PTGFRN prostaglandin F2 receptor negative regulator;
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1;
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein);
RAD1 RAD1 homolog (S. pombe);
HIC2 hypermethylated in cancer 2;
MLL2 myeloid/lymphoid or mixed-lineage leukemia 2;
EDNRB endothelin receptor type B;
NOVA1 neuro-oncological ventral antigen 1;
ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2
Mapk pathway TRAF6 TNF receptor-associated factor 6
Cell differentation NOTCH1 notch 1;
SRP14 signal recognition particle 14 kDa (homologous Alu RNA binding protein);
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3;
GDNF glial cell derived neurotrophic factor;
SMAD4 SMAD family member 4;
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G;
MED1 mediator complex subunit 1;
LIPA lipase A, lysosomal acid, cholesterol esterase;
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila);
Metabolic pathway SLC22A3 solute carrier family 22 (extraneuronal monoamine transporter), member 3;
PGP phosphoglycolate phosphatase;
LIPA lipase A, lysosomal acid, cholesterol esterase;
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex);
DOT1L DOT1-like, histone H3 methyltransferase (S. cerevisiae);
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein;
DGKG diacylglycerol kinase, gamma 90 kDa;
Neural disease IRAK1 interleukin-1 receptor-associated kinase 1;
MYT1 myelin transcription factor 1;
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila);
LRRTM2 leucine rich repeat transmembrane neuronal 2;
GRID1 glutamate receptor, ionotropic, delta 1;
SORT1 sortilin 1;
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein);
SYT1 synaptotagmin I;
NPAS4 neuronal PAS domain protein 4;
MLL2 myeloid/lymphoid or mixed-lineage leukemia 2;
DNAL1 dynein, axonemal, light chain 1;
EDNRB endothelin receptor type B;
Binding protein NOVA1 neuro-oncological ventral antigen 1;
HNRNPD heterogeneous nuclear ribonucleoprotein D
Signal trasduction ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2;
NUMB numb homolog (Drosophila);
CNTFR ciliary neurotrophic factor receptor;
SRP14 signal recognition particle 14 kDa (homologous Alu RNA binding protein);
GDNF glial cell derived neurotrophic factor;
SMAD4 SMAD family member 4;
KCTD15 potassium channel tetramerisation domain containing 15;
NF2 neurofibromin 2 (merlin);
KLF4 Kruppel-like factor 4 (gut);
SCN3B sodium channel, voltage-gated, type III, beta;
NLGN1 neuroligin 1;
RIMS2 regulating synaptic membrane exocytosis 2;
Cardiovascular disease ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2;
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2;
EDNRB endothelin receptor type B;
Ubiquitin pathway DCAF12 DDB1 and CUL4 associated factor 12;
FBXW2 F-box and WD repeat domain containing 2;
WWP2 WW domain containing E3 ubiquitin protein ligase 2;
DTL denticleless homolog (Drosophila);
Trasport protein SLC10A3 solute carrier family 10 (sodium/bile acid cotransporter family), member 3;
ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian);
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2;
SH3GL2 SH3-domain GRB2-like 2;
SLCO3A1 solute carrier organic anion transporter family, member 3A1;
GOSR1 golgi SNAP receptor complex member 1;
SLC39A1 solute carrier family 39 (zinc transporter), member 1;
SORT1 sortilin 1;
BTG2 BTG family, member 2;
Enzyme ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian);
ADARB1 adenosine deaminase, RNA-specific, B1;
USP3 ubiquitin specific peptidase 3;
KDM2B lysine (K)-specific demethylase 2B;
SIAH2 seven in absentia homolog 2 (Drosophila);
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family);
LIPA lipase A, lysosomal acid, cholesterol esterase;
CNOT6L
TRDMT1 CCR4-NOT transcription complex, subunit 6-like;
MPPE1 tRNA aspartic acid methyltransferase 1;
DCP1A DCP1 decapping enzyme homolog A (S. cerevisiae);
DLGAP2 discs, large (Drosophila) homolog-associated protein 2;
Kinase protein associated TRAF6 TNF receptor-associated factor 6;
PCDH1 protocadherin 1;
Prion disease NOTCH1 notch 1
Infection disease APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1;
PGP phosphoglycolate phosphatase;
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3;
SMAD4 SMAD family member 4;
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31 kDa;
CD28 CD28 molecule;
WASF2 WAS protein family, member 2;
SRSF7 serine/arginine-rich splicing factor 7;
Trascriptor factor MAFF v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian);
CSF1R colony stimulating factor 1 receptor;
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor;
EIF5A2 eukaryotic translation initiation factor 5A2;
KLF4 Kruppel-like factor 4 (gut);
SP8 Sp8 transcription factor;
SOX5 SRY (sex determining region Y)-box 5;
Endocrine system MED1 mediator complex subunit 1;
TP53RK TP53 regulating kinase;
Cellular antigen CD84 CD84 molecule
Mirna survelliance PPP2R3A protein phosphatase 2, regulatory subunit B’, alpha;
RIMS2 regulating synaptic membrane exocytosis 2;