Fig. 5
From: Genome-wide DNA methylome reveals the dysfunction of intronic microRNAs in major psychosis
DMRs-mediated dysfunction of intronic miRNAs contributing to expression changes. a, b Distribution of targets of hypermethylated or hypomethylated intronic DMR-related miRNAs (i.e. hyper-miRNA or hypo-miRNA) and differentially expressed genes in SZ (a) and BD (b). c, d Heat maps of GO terms enriched by different gene sets: [I] differentially expressed genes, up- and down-regulated genes; [II] DMR-related genes; [III-V] genes with DMRs, hyper-DMRs and hypo-DMRs at different genomic elements (including promoter, 5′UTR, exon, intron and 3′UTR); [VI] hypermethylated or hypomethylated intronic DMR-related genes with expression changes; [VII] up- or down-regulated targets of hypermethylated or hypomethylated intronic DMR-related miRNAs, in SZ (c) and BD (d)