Skip to main content

Table 3 Clinico-pathological characteristics according to the three patients’ age groups of the Caucasian cohort

From: Gene-expression signature functional annotation of breast cancer tumours in function of age

Patients’ group (years and [n]) n 1413 ≤40 (n = 166) 40 < x < 70 (n = 974) ≥70 (n = 273) p-value
Age (years)       
  Median (IQR) 57 (47–67) 36 (33–38) 56 (49–62) 74 (72–80)  
ER status       
  Positive 1054 (76 %) 90 (55 %) 735 (76 %) 229 (85 %) <0.0001
  Negative 341 (24 %) 73 (45 %) 227 (24 %) 41 (15 %)  
HER2 status       
  Positive 85 (23 %) 25 (36 %) 46 (19 %) 14 (22 %) 0.0407
  Negative 292 (77 %) 44 (64 %) 198 (81 %) 50 (78 %)  
Nodal status       
  Positive 498 (36 %) 62 (38 %) 319 (33 %) 117 (46 %) 0.0263
  Negative 889 (64 %) 100 (62 %) 651 (67 %) 138 (54 %)  
SBR grade       
  1 254 (19 %) 12 (8 %) 182 (20 %) 60 (24 %) <0.0001
  2 571 (44 %) 57 (36 %) 403 (45 %) 111 (44 %)  
  3 482 (47 %) 88 (56 %) 311 (35 %) 83 (33 %)  
Tumour size      
  ≤20 mm 537 (49 %) 46 (47 %) 388 (50 %) 103 (45 %) 0.4794
  >20 mm 567 (51 %) 52 (53 %) 390 (50 %) 125 (55 %)  
  1. Abbreviations: ER oestrogen receptor, IQR interquartile range, SBR Scarff-Bloom-Richardson histological grade