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Table 3 Clinico-pathological characteristics according to the three patients’ age groups of the Caucasian cohort

From: Gene-expression signature functional annotation of breast cancer tumours in function of age

Patients’ group (years and [n])

n 1413

≤40 (n = 166)

40 < x < 70 (n = 974)

≥70 (n = 273)

p-value

Age (years)

      
 

Median (IQR)

57 (47–67)

36 (33–38)

56 (49–62)

74 (72–80)

 

ER status

      
 

Positive

1054 (76 %)

90 (55 %)

735 (76 %)

229 (85 %)

<0.0001

 

Negative

341 (24 %)

73 (45 %)

227 (24 %)

41 (15 %)

 

HER2 status

      
 

Positive

85 (23 %)

25 (36 %)

46 (19 %)

14 (22 %)

0.0407

 

Negative

292 (77 %)

44 (64 %)

198 (81 %)

50 (78 %)

 

Nodal status

      
 

Positive

498 (36 %)

62 (38 %)

319 (33 %)

117 (46 %)

0.0263

 

Negative

889 (64 %)

100 (62 %)

651 (67 %)

138 (54 %)

 

SBR grade

      
 

1

254 (19 %)

12 (8 %)

182 (20 %)

60 (24 %)

<0.0001

 

2

571 (44 %)

57 (36 %)

403 (45 %)

111 (44 %)

 
 

3

482 (47 %)

88 (56 %)

311 (35 %)

83 (33 %)

 

Tumour size

     
 

≤20 mm

537 (49 %)

46 (47 %)

388 (50 %)

103 (45 %)

0.4794

 

>20 mm

567 (51 %)

52 (53 %)

390 (50 %)

125 (55 %)

 
  1. Abbreviations: ER oestrogen receptor, IQR interquartile range, SBR Scarff-Bloom-Richardson histological grade