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Table 1 Pathways that are enriched with CIS-associated genes (permuted p value <10−7)

From: Case-oriented pathways analysis in pancreatic adenocarcinoma using data from a sleeping beauty transposon mutagenesis screen

  KEGG id Pathway name # of genes # of CIS # of mutated cases
   Cellular Processes    
1 4110 Cell cycle 126 9 101
2 4530 Tight junction 136 10 127
3 4810 Regulation of actin cytoskeleton 217 13 121
4 4510 Focal adhesion 207 13 123
5 4540 Gap junction 87 3 67
6 4520 Adherens junction 74 11 122
   Human Diseases    
7 5164 Influenza A 170 11 117
8 5034 Alcoholism 199 5 85
9 5169 Epstein-Barr virus infection 212 17 120
10 5203 Viral carcinogenesis 229 14 116
11 5160 Hepatitis C 136 7 97
12 5010 Alzheimer’s disease 173 12 121
13 5016 Huntington’s disease 182 14 125
14 5200 Pathways in cancer 323 23 134
15 5211 Renal cell carcinoma 67 6 84
16 5206 MicroRNAs in cancer 270 10 108
17 5152 Tuberculosis 176 11 114
18 5166 HTLV-I infection 277 11 106
19 5100 Bacterial invasion of epithelial cells 77 7 103
20 5412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 74 7 96
21 5202 Transcriptional misregulation in cancer 178 12 121
22 5133 Pertussis 74 6 84
23 5142 Chagas disease (American trypanosomiasis) 103 7 87
24 5161 Hepatitis B 145 10 107
25 5205 Proteoglycans in cancer 226 11 115
26 5214 Glioma 65 6 95
27 5216 Thyroid cancer 29 3 66
28 5210 Colorectal cancer 64 8 105
29 5212 Pancreatic cancer 66 6 74
30 5213 Endometrial cancer 52 8 111
31 5215 Prostate cancer 89 10 117
32 5218 Melanoma 71 4 86
33 5219 Bladder cancer 38 2 46
34 5220 Chronic myeloid leukemia 73 9 95
35 5221 Acute myeloid leukemia 57 6 82
36 5223 Non-small cell lung cancer 56 5 77
37 5222 Small cell lung cancer 85 7 95
38 5217 Basal cell carcinoma 55 3 65
   Environmental Information Processing    
39 4151 PI3K-Akt signaling pathway 351 22 130
40 4390 Hippo signaling pathway 154 14 123
41 4066 HIF-1 signaling pathway 111 7 91
42 4012 ErbB signaling pathway 87 7 100
43 4014 Ras signaling pathway 228 13 119
44 4310 Wnt signaling pathway 143 16 126
45 4350 TGF-beta signaling pathway 82 11 119
46 4010 MAPK signaling pathway 253 14 118
47 4015 Rap1 signaling pathway 216 14 134
48 4370 VEGF signaling pathway 60 4 68
49 4340 Hedgehog signaling pathway 49 3 61
50 4330 Notch signaling pathway 49 4 68
51 4070 Phosphatidylinositol signaling system 81 4 78
52 4068 FoxO signaling pathway 135 7 101
53 4150 mTOR signaling pathway 61 4 86
   Metabolism    
54 4141 Protein processing in endoplasmic reticulum 169 8 111
55 670 One carbon pool by folate 19 2 45
56 3015 mRNA surveillance pathway 96 8 95
57 4120 Ubiquitin mediated proteolysis 139 14 118
58 00250 Alanine, aspartate and glutamate metabolism 34 2 53
59 3020 RNA polymerase 29 2 50
60 510 N-Glycan biosynthesis 50 3 69
61 3018 RNA degradation 77 5 83
62 310 Lysine degradation 51 6 95
63 512 Mucin type O-Glycan biosynthesis 28 2 46
64 900 Terpenoid backbone biosynthesis 21 2 54
65 563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis 25 2 46
66 4122 Sulfur relay system 10 3 59
67 4062 Chemokine signaling pathway 196 13 124
68 4722 Neurotrophin signaling pathway 123 12 118
69 4670 Leukocyte transendothelial migration 121 9 106
70 4728 Dopaminergic synapse 133 8 105
71 4270 Vascular smooth muscle contraction 137 8 104
72 4713 Circadian entrainment 98 5 93
73 4723 Retrograde endocannabinoid signaling 103 4 88
74 4724 Glutamatergic synapse 114 5 93
75 4725 Cholinergic synapse 113 5 93
76 4726 Serotonergic synapse 133 5 94
77 4910 Insulin signaling pathway 142 8 95
78 4650 Natural killer cell mediated cytotoxicity 146 5 73
79 4917 Prolactin signaling pathway 74 7 98
80 4611 Platelet activation 131 9 111
81 4912 GnRH signaling pathway 89 5 80
82 4914 Progesterone-mediated oocyte maturation 87 4 68
83 4915 Estrogen signaling pathway 98 6 92
84 4916 Melanogenesis 100 9 111
85 4921 Oxytocin signaling pathway 158 9 108
86 4360 Axon guidance 129 10 117
87 4919 Thyroid hormone signaling pathway 118 11 114
88 4960 Aldosterone-regulated sodium reabsorption 40 2 49
89 4720 Long-term potentiation 66 6 91
90 4660 T cell receptor signaling pathway 105 9 113
91 4662 B cell receptor signaling pathway 73 6 91
92 4730 Long-term depression 61 3 67
93 4664 Fc epsilon RI signaling pathway 70 4 68
94 4666 Fc gamma R-mediated phagocytosis 88 6 86
95 4320 Dorso-ventral axis formation 22 2 60