Case-oriented pathways analysis in pancreatic adenocarcinoma using data from a sleeping beauty transposon mutagenesis screen

Ho, Yen-Yi; Starr, Timothy K.; LaRue, Rebecca S.; Largaespada, David A.

doi:10.1186/s12920-016-0176-7

Table 1 Pathways that are enriched with CIS-associated genes (permuted p value <10⁻⁷)

From: Case-oriented pathways analysis in pancreatic adenocarcinoma using data from a sleeping beauty transposon mutagenesis screen

	KEGG id	Pathway name	# of genes	# of CIS	# of mutated cases
		Cellular Processes
1	4110	Cell cycle	126	9	101
2	4530	Tight junction	136	10	127
3	4810	Regulation of actin cytoskeleton	217	13	121
4	4510	Focal adhesion	207	13	123
5	4540	Gap junction	87	3	67
6	4520	Adherens junction	74	11	122
		Human Diseases
7	5164	Influenza A	170	11	117
8	5034	Alcoholism	199	5	85
9	5169	Epstein-Barr virus infection	212	17	120
10	5203	Viral carcinogenesis	229	14	116
11	5160	Hepatitis C	136	7	97
12	5010	Alzheimer’s disease	173	12	121
13	5016	Huntington’s disease	182	14	125
14	5200	Pathways in cancer	323	23	134
15	5211	Renal cell carcinoma	67	6	84
16	5206	MicroRNAs in cancer	270	10	108
17	5152	Tuberculosis	176	11	114
18	5166	HTLV-I infection	277	11	106
19	5100	Bacterial invasion of epithelial cells	77	7	103
20	5412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	74	7	96
21	5202	Transcriptional misregulation in cancer	178	12	121
22	5133	Pertussis	74	6	84
23	5142	Chagas disease (American trypanosomiasis)	103	7	87
24	5161	Hepatitis B	145	10	107
25	5205	Proteoglycans in cancer	226	11	115
26	5214	Glioma	65	6	95
27	5216	Thyroid cancer	29	3	66
28	5210	Colorectal cancer	64	8	105
29	5212	Pancreatic cancer	66	6	74
30	5213	Endometrial cancer	52	8	111
31	5215	Prostate cancer	89	10	117
32	5218	Melanoma	71	4	86
33	5219	Bladder cancer	38	2	46
34	5220	Chronic myeloid leukemia	73	9	95
35	5221	Acute myeloid leukemia	57	6	82
36	5223	Non-small cell lung cancer	56	5	77
37	5222	Small cell lung cancer	85	7	95
38	5217	Basal cell carcinoma	55	3	65
		Environmental Information Processing
39	4151	PI3K-Akt signaling pathway	351	22	130
40	4390	Hippo signaling pathway	154	14	123
41	4066	HIF-1 signaling pathway	111	7	91
42	4012	ErbB signaling pathway	87	7	100
43	4014	Ras signaling pathway	228	13	119
44	4310	Wnt signaling pathway	143	16	126
45	4350	TGF-beta signaling pathway	82	11	119
46	4010	MAPK signaling pathway	253	14	118
47	4015	Rap1 signaling pathway	216	14	134
48	4370	VEGF signaling pathway	60	4	68
49	4340	Hedgehog signaling pathway	49	3	61
50	4330	Notch signaling pathway	49	4	68
51	4070	Phosphatidylinositol signaling system	81	4	78
52	4068	FoxO signaling pathway	135	7	101
53	4150	mTOR signaling pathway	61	4	86
		Metabolism
54	4141	Protein processing in endoplasmic reticulum	169	8	111
55	670	One carbon pool by folate	19	2	45
56	3015	mRNA surveillance pathway	96	8	95
57	4120	Ubiquitin mediated proteolysis	139	14	118
58	00250	Alanine, aspartate and glutamate metabolism	34	2	53
59	3020	RNA polymerase	29	2	50
60	510	N-Glycan biosynthesis	50	3	69
61	3018	RNA degradation	77	5	83
62	310	Lysine degradation	51	6	95
63	512	Mucin type O-Glycan biosynthesis	28	2	46
64	900	Terpenoid backbone biosynthesis	21	2	54
65	563	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis	25	2	46
66	4122	Sulfur relay system	10	3	59
67	4062	Chemokine signaling pathway	196	13	124
68	4722	Neurotrophin signaling pathway	123	12	118
69	4670	Leukocyte transendothelial migration	121	9	106
70	4728	Dopaminergic synapse	133	8	105
71	4270	Vascular smooth muscle contraction	137	8	104
72	4713	Circadian entrainment	98	5	93
73	4723	Retrograde endocannabinoid signaling	103	4	88
74	4724	Glutamatergic synapse	114	5	93
75	4725	Cholinergic synapse	113	5	93
76	4726	Serotonergic synapse	133	5	94
77	4910	Insulin signaling pathway	142	8	95
78	4650	Natural killer cell mediated cytotoxicity	146	5	73
79	4917	Prolactin signaling pathway	74	7	98
80	4611	Platelet activation	131	9	111
81	4912	GnRH signaling pathway	89	5	80
82	4914	Progesterone-mediated oocyte maturation	87	4	68
83	4915	Estrogen signaling pathway	98	6	92
84	4916	Melanogenesis	100	9	111
85	4921	Oxytocin signaling pathway	158	9	108
86	4360	Axon guidance	129	10	117
87	4919	Thyroid hormone signaling pathway	118	11	114
88	4960	Aldosterone-regulated sodium reabsorption	40	2	49
89	4720	Long-term potentiation	66	6	91
90	4660	T cell receptor signaling pathway	105	9	113
91	4662	B cell receptor signaling pathway	73	6	91
92	4730	Long-term depression	61	3	67
93	4664	Fc epsilon RI signaling pathway	70	4	68
94	4666	Fc gamma R-mediated phagocytosis	88	6	86
95	4320	Dorso-ventral axis formation	22	2	60

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