Table 1 Included SNPs and action and location of involved miRNA biogenesis genes

ADAR

rs11264222, rs1127309, rs1127313, rs1127314, rs1127317, rs2131902, rs2229857, rs2335230, rs3766925, rs376692, rs4845384

N

Pre-miRNA Editing

AGO1

rs636832, rs11584005^f, rs595055^c

C

miRISC Formation/Loading

AGO2

rs10087629, rs1060832, rs11166984, rs11166985, rs13276958, rs1878478, rs2176397, rs2271735, rs2292775, rs2292780, rs2293939, rs2944761, rs2944767, rs2944776, rs2977469, rs2977477, rs2977490, rs3735805, rs3864659, rs3928672, rs4961278, rs6985156, rs7009635, rs7824304, rs7843258, rs7460^a, rs2944760

AGO3

rs10796876, rs274732, rs4351606

AGO4

rs12044203, rs12119583

BMP2

rs15705, rs2273073, rs235768, rs3178250

N

Recruitment of SMAD/Enhancement of Drosha

BMP3

rs3733549

BMP4

rs17563, rs76335800^f

BMP6

rs1043784, rs1044104, rs7764128, rs9505298

DCP1B

rs2240610, rs6489338

C

Localization with AGO & P-bodies/mRNA Decapping for Degradation

DDX10

rs10890898, rs2726920

C

Pre-miRNA Unwinding/Possible Drosha Processing Enhancement. DDX5-DDX17 Required for Recognition of pri-miRNA By Drosha.

DDX11

rs1808348, rs2075321, rs7953706, rs9750

DDX13 (SKIV2L)

rs437179 (rs438999, rs449643 only SKIV2L)

DDX20

rs11584657, rs197381^a, rs197392, rs197412, rs197414, rs538779

DDX5 (p68)

rs1991401, rs1140409

DGCR8

rs11089328, rs1558496, rs1640297, rs17817767, rs2073778, rs2286926, rs2286928, rs41281429, rs417309, rs9606248

N

Pri-miRNA Cleavage

DHX15

rs6841898

C

May Interact with AGO1/2, Dicer, TRBP/Facilitate mi/siRNA Loading (DHX6,9).

DHX16

rs3130000

DICER1

rs10149095, rs1057035, rs11160231, rs11622643, rs11624081, rs1209904, rs12323635, rs12897280, rs13078, rs17091855, rs3742330, rs4513027, rs1110386, rs11621737

C

Pre-miRNA Cleavage

DROSHA

rs10052174, rs10067066, rs10068052, rs10719, rs11748548, rs13169883, rs13183642, rs16901109, rs16901165, rs17408227, rs17408716, rs17409624, rs17409803, rs17410035, rs17485323, rs2279797, rs2287584, rs3792830, rs3805525, rs4867329^f, rs4867339, rs493760, rs524138, rs573010, rs639174, rs6450848, rs673019, rs6878195, rs6884823, rs7447423, rs7712155, rs7712436, rs7719666, rs13175906^a, rs2330696^a, rs6883386^a, rs7702984^f

N

Pri-miRNA Cleavage

FMR1

rs25704^f

C

P-bodies and mRNA Degradation

GEMIN4

rs1045481, rs1062923, rs2251689, rs2291778, rs2740348, rs2740349, rs3744741, rs7813, rs28685132^f, rs2740351

C

miRNA Duplex Unwinding (miRISC formation)

GSK3β

rs3732361, rs56728675, rs60393216

C

Drosha Phosphorylation/Stabilization

LIN28

rs11247946, rs11587947^a

N

Recruites ZCCHC11 to miRNA for Uridylation

LIN28A

rs12741800^a, rs12728900, rs6598964, rs6697410

LIN28B

rs12194974, rs17065417

Microprocessor Regulation

MAP3K19

rs13390171^f, rs1551497^f, rs2322254^f

C

TRBP Phosphorylation/Stabilization

MAPK1

rs13515, rs2283792, rs6928, rs7286558, rs743409, rs8136867, rs9607272

MAPK14

rs3804452, rs8510

MAPK3

rs11865086

MAPKAPK2

rs4240847, rs4548444, rs45514798

MOV10

rs2932538

C

miRNA Duplex Unwinding (miRISC formation)

p38 (CRK)

rs1083

N

AGO2 Phosphorylation/P-body Localization

p38 (GRAP)

rs138011, rs138012

p54 (FKBP5)

rs3800373, rs755658

C

Localization with P-bodies/mRNA Degradation and/or Storage

p54 (IFIT2)

rs17468739, rs2070845

rs11061209

PACT (PRKRA)

rs2059691, rs1967327, rs10207436^e

N

Associates with Dicer; Role Undetermined

PACT (RBBP6)

rs11860248, rs2033214, rs7195386

RAN

rs10848237, rs14035, rs3809142, rs10773831

Both

Ran-GTP Associates with XPO5 for Export

SMAD4

rs948588

N

Drosha Processing Enhancement

TGFB1

rs1800468, rs1800470^f, rs1800471, rs1800472

N

Recruitment of SMAD/Enhancement of Drosha

TNRC6A (GW182)

rs1030211, rs11639856, rs11642302, rs11644976, rs12917810, rs1633445, rs2303085, rs4788430, rs6497755,

C

P-bodies and mRNA Degradation

TNRC6B

rs7291691^a

TRBP (NCOA6)

rs4911442, rs6088619, rs910871

C

Pre-miRNA Cleavage

TRBP (NPFF)

rs8192593

TRBP (TARBP2)

rs34649330, rs784567

XPO5

rs1106841, rs11077, rs17287964, rs2257082, rs699937, rs7755135

Both

Nuclear Export of Pre-miRNA to Cytoplasm

ZCCHC11 (TUT4)

rs2274147, rs835036

C

Uridylation of Pre-miRNA/Dicer Inhibition