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Table 5 Clusters significantly associated with polygenic risk scores of all rare variants within PSEN1 after multiple testing correction

From: Integration of bioinformatics and imaging informatics for identifying rare PSEN1 variants in Alzheimer’s disease

Cluster Cluster size (# of vertex) Anatomic localization Corrected p-value
1 3,798 right frontal lobe 8.96 × 10−6
2 4,247 right frontal lobe 2.29 × 10−5
3 3,436 right parietal lobe 1.23 × 10−4
4 2,718 left frontal lobe 7.11 × 10−3
5 1,915 left temporal lobe 2.04 × 10−2
6 2,078 left temporal lobe 3.33 × 10−2