Table 5 Clusters significantly associated with polygenic risk scores of all rare variants within PSEN1 after multiple testing correction
Cluster | Cluster size (# of vertex) | Anatomic localization | Corrected p-value |
|---|---|---|---|
1 | 3,798 | right frontal lobe | 8.96 × 10−6 |
2 | 4,247 | right frontal lobe | 2.29 × 10−5 |
3 | 3,436 | right parietal lobe | 1.23 × 10−4 |
4 | 2,718 | left frontal lobe | 7.11 × 10−3 |
5 | 1,915 | left temporal lobe | 2.04 × 10−2 |
6 | 2,078 | left temporal lobe | 3.33 × 10−2 |