Table 5 Significantly enriched GO BP terms (top 5) for the largest connected component of integrative regression network of methylation features
From: Integrative regression network for genomic association study
Cancer type | Category | Term | N | p-value | FDR |
|---|---|---|---|---|---|
Breast | GOTERM_BP_FAT | GO:0006468 ~ protein amino acid phosphorylation | 11 | 1.32e-07 | 2.05e-04 |
INTERPRO | IPR008266:Tyrosine protein kinase, active site | 6 | 2.35e-07 | 2.55e-04 | |
UP_SEQ_FEATURE | binding site:ATP | 9 | 2.81e-07 | 3.32e-04 | |
INTERPRO | IPR001245:Tyrosine protein kinase | 6 | 6.25e-07 | 6.80e-04 | |
GOTERM_MF_FAT | GO:0004672 ~ protein kinase activity | 10 | 6.90e-07 | 7.94e-04 | |
Colon | SP_PIR_KEYWORDS | tyrosine-protein kinase | 12 | 1.86e-12 | 2.33e-09 |
INTERPRO | IPR008266:Tyrosine protein kinase, active site | 12 | 1.91e-12 | 2.50e-09 | |
INTERPRO | IPR001245:Tyrosine protein kinase | 12 | 1.69e-11 | 2.21e-08 | |
SP_PIR_KEYWORDS | signal | 40 | 2.90e-10 | 3.63e-07 | |
UP_SEQ_FEATURE | signal peptide | 40 | 3.51e-10 | 4.94e-07 | |
GBM | GOTERM_BP_FAT | GO:00042127 ~ regulation of cell proliferation | 88 | 8.57e-42 | 1.52e-38 |
SP_PIR_KEYWORDS | signal | 128 | 5.54e-29 | 7.73e-26 | |
UP_SEQ_FEATURE | signal peptide | 128 | 1.03e-28 | 1.66e-25 | |
GOTERM_BP_FAT | GO:0008284 ~ positive regulation of cell proliferation | 54 | 5.23e-28 | 9.28e-25 | |
INTERPRO | IPR001245:Tyrosine protein kinase | 27 | 3.51e-22 | 5.21e-19 | |
Kidney | GOTERM_BP_FAT | GO:0010033 ~ response to organic substance | 19 | 4.24e-08 | 6.99e-05 |
GOTERM_BP_FAT | GO:0043067 ~ regulation of programmed cell death | 18 | 1.30e-06 | 0.00214 | |
GOTERM_BP_FAT | GO:0010941 ~ regulation of cell death | 18 | 1.37e-06 | 0.00225 | |
GOTERM_MF_FAT | GO:0032403 ~ protein complex binding | 10 | 1.61e-06 | 0.00215 | |
KEGG_PATHWAY | has05200:Pathways in cancer | 14 | 1.65e-06 | 0.00174 | |
Lung | GOTERM_BP_FAT | GO:0042127 ~ regulation of cell proliferation | 25 | 6.24e-13 | 1.02e-09 |
SP_PIR_KEYWORDS | Proto-oncogene | 14 | 4.78e-12 | 5.92e-09 | |
KEGG_PATHWAY | has05200:Pathways in cancer | 22 | 6.02e-12 | 6.56e-09 | |
GOTERM_BP_FAT | GO:0007169 ~ transmembrane receptor protein tyrosine kinase signaling pathway | 14 | 1.24e-10 | 2.02e-07 | |
GOTERM_BP_FAT | GO:000716 ~ enzyme linked receptor protein signaling pathway | 16 | 2.06e-10 | 3.37e-07 |