BMC Medical Genomics

Table 1 Genes selected by FEs

From: SFRP1 is a possible candidate for epigenetic therapy in non-small cell lung cancer

	(A)	(B)	(C)	(D)		(A)	(B)	(C)	(D)		(A)	(B)	(C)	(D)
Categorical regression					SFRP1	○	○	○	○	LAMC2	○	○	○	○
SALL4	○	○	○	○	SLC16A12					HMGA1	○	○	○	○
TACSTD1*	○	○	○	○	HOXA5	○	○	○	○	LAD1		○	○
ANGPT1	○		○	○	KIF1A		○	○	○	PFKFB3	○		○	○
TACSTD2*	○	○	○	○	H2AFY	○	○	○		DEFB1	○		○
IGSF21					ATP5G2					SRGN	○	○	○
EFNB1	○		○	○	TM4SF1	○	○	○	○	UCHL1	○	○	○	○
MEST	○	○	○	○	GPR56*	○	○	○	○	ALDH3A1	○	○	○	○
SCG3			○		S100P	○	○	○	○	EPB41L3	○		○	○
PCA based unsupervised FE (PC4)					PCA based unsupervised FE (PC4)					RTN1	○	○	○
F2R	○	○	○	○	SPINT2	○	○	○	○	LAMA1	○		○	○
DKK3	○	○	○	○	CDH1	○	○	○	○

Genes with asterisk were selected by more than one method
(A) Associations with cancer related genes reported by Gendoo server. (B) Significant negative correlations (P < 0.05) between gene expression and promoter methylation. (C) At least one study reported a direct/indirect relationship with NSCLC. (D) At least one study reported a direct/indirect relationship with Wnt/β-catenin signalling pathways. Asterisked three genes are also identified by PCA based unsupervised FE with PC4

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