Fig. 5
From: Frequent hypermethylation of orphan CpG islands with enhancer activity in cancer
Dynamic tumorigenic changes of DNA methylation in the eCGIs. a Heatmap showing aberrant DNA methylation of the eCGIs in Mcf7 cell line (left) and clinical cancer data (right). b Boxplots showing that the eCGIs are more hypermethylated than the pCGIs in both cell lines (left) and clinical data (right). c Down-regulation of the target genes of the hypermethylated eCGIs in Mcf7 cell line and clinical cancer data. d Global loss of DHS and H3K27ac signals at hypermethylated eCGIs in Mcf7. e Fisher-exact test for enrichment of target genes of hypermethylated eCGIs on tumor suppressor genes