Fig. 4

Behavior of DEG biomarkers in a validation cohort. The 37 DEG biomarker set was applied to transcript expression levels in patients being treated for either appendicitis (APP, green bars), lower respiratory infection (LRI, red bars), or hernias (HER, blue bars). Representative transcripts, such as Fc gamma receptor 3 (FCGR3) and ninjurin 1 (NINJ1) are shown, in which the transcript behaves with relatively selective induction in APP, relative to HER or LRI. Conversely, transcripts in the defensin family (DEFA1, DEFA3), are significantly elevated in HER patients, relative to APP, but are strikingly induced in LRI patients. Most transcripts, such as alkaline phosphatase (ALPL) and the CXCL8 (IL-8) receptors (CXCR2/IL8RB, CXCR1), were induced in both APP and LRI patients