Fig. 1
From: Identifying enriched drug fragments as possible candidates for metabolic engineering
Simplified overview of the pipeline. Each approved drug (obtained from Drugbank [24]) is assigned a therapeutic class using the ATC nomenclature. The drugs are then broken down into fragments using the molBLOCKS software [26], and enrichment analysis is performed on each therapeutic class to identify statistically overrepresented fragments (FDR <0.05). Each overrepresented fragment is then compared against similarly obtained fragments from a database of natural compounds [12] (see Materials and Methods for further details)