Fig. 2

Comparison of performance for the MFM with other methods. We applied CMap datasets to compare performance of MFM with Shegemizu et al. and Lamb et al. The sensitivity and specificity were calculated as explained in the Methods section, and the area under the ROC curve was used as a measure of performance. UCDB: prediction of drug candidates that can down-regulate genes up-regulated in cancer. DCUB: prediction of drug candidates that can up-regulate genes down-regulated in cancer. It shows that MFM consistently outperforms the two methods in different datasets and diseases